3-Hydroxyphthalic Anhydride

Product Information

Molecular Formula:
C8H4O4
Molecular Weight:
164.11
Description
3-Hydroxyphthalic Anhydride (CAS# 37418-88-5) is used to synthesize 3-Hydroxyphthalic Anhydride-modified human serum albumin whichhas high potency as a microbicide for prevention of the sexual transmission of HIV. It is also used as a reagent in organicsynthesis of other compounds including that of inhibitors of NF-κB derived from thalidomide.
Synonyms
4-hydroxyisobenzofuran-1,3-dione; 4-hydroxy-2-benzofuran-1,3-dione
IUPAC Name
4-hydroxy-2-benzofuran-1,3-dione
Canonical SMILES
C1=CC2=C(C(=C1)O)C(=O)OC2=O
InChI
InChI=1S/C8H4O4/c9-5-3-1-2-4-6(5)8(11)12-7(4)10/h1-3,9H
InChI Key
CCTOEAMRIIXGDJ-UHFFFAOYSA-N
Boiling Point
365.4 °C at 760 mmHg
Melting Point
199-202 °C (lit.)
Purity
98 %
Density
1.625 g/cm3
LogP
0.70280

Safety Information

Hazards
H315 - H319 - H335
Precautionary Statement
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word
Warning

Computed Properties

XLogP3
1.5
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
0
Exact Mass
164.01095860 g/mol
Monoisotopic Mass
164.01095860 g/mol
Topological Polar Surface Area
63.6Ų
Heavy Atom Count
12
Formal Charge
0
Complexity
235
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-113925168-A Application of EGCG quinone as inhibitor for resisting AGEs (angiotensin-converting enzyme) release in gastrointestinal tract 2021-10-28
CN-113979996-A Phthalimide fluorescent probe for detecting copper ions, preparation method and application thereof, and copper ion detection method 2021-10-27
CN-113686828-A CdTe quantum dot-based ratiometric fluorescent probe and application thereof in hydrazine hydrate detection 2021-08-25
CN-113171445-A Modified beta-lactoglobulin and biological preparation for preventing and treating HPV (human papillomavirus) virus infection 2021-04-30
CN-112891520-A Preparation method of active biological protein for preventing and controlling Human Papilloma Virus (HPV) infection 2021-04-13
CN-112980194-A LED packaging material and preparation method thereof 2021-03-04
CN-112999358-A Bioactive protein for preventing and treating human papilloma virus infection, preparation method and application thereof 2021-03-04
TW-I739715-B Polyimide resin composition, polyimide resin adhesive layer, laminate, and manufacturing method of electronic component 2021-02-26
CN-112500570-A Flexible display device, polyamic acid varnish for display, and polyimide film 2021-02-04
CN-112500570-B Flexible display device, polyamic acid varnish for display, and polyimide film 2021-02-04

Literatures

PMID Publication Date Title Journal
22819190 2012-08-15 Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists Bioorganic & medicinal chemistry
21764688 2011-06-01 [Antiviral activity of 3-hydroxyphthalic anhydride-modified ovalbumin against herpes simplex virus 2 in vitro] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
21239999 2011-04-15 Combinations of 3-hydroxyphthalic anhydride-modified ovalbumin with antiretroviral drug-based microbicide candidates display synergistic and complementary effects against HIV-1 infection Journal of acquired immune deficiency syndromes (1999)
20420669 2010-04-26 Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission Retrovirology
12834857 2003-06-01 The antiviral activity of naturally occurring proteins and their peptide fragments after chemical modification Antiviral research
11388489 2001-04-01 7-Hydroxyphthalide: a new natural salicylaldehyde analog from Oulenzia sp. (Astigmata: Winterschmitiidae) Bioscience, biotechnology, and biochemistry
11272824 2001-01-01 Synthesis of corollosporine, an antibacterial metabolite of the marine fungus Corollospora maritima Bioscience, biotechnology, and biochemistry
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Related Products

Online Inquiry
  • Verification code
USA
  • International: 1-631-504-6093
  • US & Canada (Toll free): 1-844-BOC(262)-0123
  • 45-16 Ramsey Road, Shirley, NY 11967, USA
  • Email: info@bocsci.com
  • Fax: 1-631-614-7828
UK
  • 44-20-3980-8385
  • 85 Great Portland Street, London, W1W 7LT
  • Email: info@bocsci.com
Copyright © 2025 BOC Sciences. All rights reserved.
Top
0
Inquiry Basket

We use cookies to understand how you use our site and to improve the overall user experience. This includes personalizing content and advertising. Read our Privacy Policy

Accept Cookies
x