CHAPSO

Product Information

Molecular Formula:
C32H58N2O8S
Molecular Weight:
630.88
Description
CHAPSO is a zwitterionic detergent derived from Chaps by the addition of a functional hydroxyl group. CHAPSO is capable of solubilizing opiate receptor to a state exhibiting reversible binding of opiates. It has higher solubility than CHAPS because of its more polar head group.
Synonyms
3-((3-cholamidopropyl)dimethylammonio)-2-hydroxy-1-propanesulfonate
IUPAC Name
3-[dimethyl-[3-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]propyl]azaniumyl]-2-hydroxypropane-1-sulfonate
Canonical SMILES
CC(CCC(=O)NCCC[N+](C)(C)CC(CS(=O)(=O)[O-])O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C
InChI
InChI=1S/C32H58N2O8S/c1-20(7-10-29(39)33-13-6-14-34(4,5)18-23(36)19-43(40,41)42)24-8-9-25-30-26(17-28(38)32(24,25)3)31(2)12-11-22(35)15-21(31)16-27(30)37/h20-28,30,35-38H,6-19H2,1-5H3,(H-,33,39,40,41,42)/t20-,21+,22-,23?,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1
InChI Key
GUQQBLRVXOUDTN-XOHPMCGNSA-N
Melting Point
184-186°C(lit.)
Flash Point
320 °F
Purity
Purity >98%
Appearance
White Crystalline Powder
Shelf Life
1 Year
Storage
Store at -20°C

Computed Properties

XLogP3
1.9
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
8
Rotatable Bond Count
11
Exact Mass
630.39138799 g/mol
Monoisotopic Mass
630.39138799 g/mol
Topological Polar Surface Area
176Ų
Heavy Atom Count
43
Formal Charge
0
Complexity
1070
Isotope Atom Count
0
Defined Atom Stereocenter Count
11
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-114137222-A Kit for detecting tissue metal protease inhibitor-1 in body fluid sample 2021-11-22
CN-113564051-A Cell mass digestion dissociation liquid and cell counting method 2021-07-07
CN-113278048-A Purification method of membrane protein 2021-05-26
CN-113061591-A Novel firefly luciferase mutant, preparation method and application thereof 2021-03-31
CN-113061591-B Novel firefly luciferase mutant, preparation method and application thereof 2021-03-31
US-2022077449-A1 Electrochemical cells, components thereof, and methods of their manufacture 2020-09-08
WO-2022049294-A1 Method for detecting contaminating lipase activity 2020-09-07
WO-2022049211-A1 Methods for the preparation of bioconjugates 2020-09-02
WO-2022042542-A1 A fusion protein as a subunit vaccine immunogen against sars-cov-2 and preparation method thereof 2020-08-27
WO-2022046900-A1 Methods and reagents for rapid detection of pathogens in biological samples 2020-08-25

Literatures

PMID Publication Date Title Journal
22257923 2012-01-09 High-throughput crystallization of membrane proteins using the lipidic bicelle method Journal of visualized experiments : JoVE
20235510 2010-04-08 Interactions of hemin with model erythrocyte membranes The journal of physical chemistry. B
18480063 2008-07-11 Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states The Journal of biological chemistry
17663636 2007-01-01 Biochemical properties of endogenous presenilin 1 and presenilin 2 in cultured human B-lymphocytes Clinical chemistry and laboratory medicine
15912955 2005-03-01 3-O-alkyl-D-glucose derivatives induce fruit bodies of Pleurotus ostreatus Mycological research
15456764 2004-12-03 Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria The Journal of biological chemistry
15592142 2004-10-01 Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells Alzheimer disease and associated disorders
15341515 2004-09-01 Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding Journal of neurochemistry
15222759 2004-07-06 Effect of membrane perturbants on the activity and phase distribution of inositol phosphorylceramide synthase; development of a novel assay Biochemistry
12857757 2003-09-26 Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin The Journal of biological chemistry
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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