Hexamethylphosphorous triamide

Product Information

Molecular Formula:
C6H18N3P
Molecular Weight:
163.2
Description
Tris(dimethylamino)phosphine can be used a reagent in combination with CCl4 for the conversion of hydroxyl groups to the corresponding chlorides; for hydroxyl group activation; dehydrations.
Tris(dimethylamino)phosphine can be used as a:• Ligand in the preparation of arene-ruthenium(II) complex which is used as a catalyst in hydration of nitriles to amides.• Phosphorus source along with InCl3 in the synthesis of InP colloidal quantum dots (QDs).• Deoxygenating agent for some α-dicarbonyl compounds in the presence of fullerene C60.
Synonyms
((CH3)2N)3P; Hexametapil; hexamethyl-phosphoroustriamid; Hexamethyltriamidophosphite; Phosphine, Tris(dimethylamino)-; Phosphoroustriamide,hexamethyl-; HEXAMETHYLTRIAMINOPHOSPHINE; HEXAMETHYL PHOSPHORUS TRIAMIDE
IUPAC Name
N-[bis(dimethylamino)phosphanyl]-N-methylmethanamine
Canonical SMILES
CN(C)P(N(C)C)N(C)C
InChI
InChI=1S/C6H18N3P/c1-7(2)10(8(3)4)9(5)6/h1-6H3
InChI Key
XVDBWWRIXBMVJV-UHFFFAOYSA-N
Boiling Point
48-50 °C/12 mmHg (lit.)
Flash Point
80.6 °F - closed cup
Purity
97%
Density
0.898
Appearance
Colorless liquid which may contain some precipitate
Application
A compound widely used in industry, with applications such as being a flame retardant for building materials to a phosphorylating agent in synthetic chemistry. It is a classified carcinogen.
Refractive Index
n20/D 1.463 (lit.)

Safety Information

Hazards
H226 - H340 - H350
Precautionary Statement
P201 - P210 - P308 + P313

Computed Properties

XLogP3
0.6
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
3
Exact Mass
163.12383458 g/mol
Monoisotopic Mass
163.12383458 g/mol
Topological Polar Surface Area
9.7Ų
Heavy Atom Count
10
Formal Charge
0
Complexity
74
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-114163368-A Synthetic thioether compounds and process for their preparation 2021-12-17
CN-114057791-A Hydrolysis-resistant phosphite ligand, preparation method and application thereof in preparation of linear aldehyde by catalyzing hydroformylation reaction of olefin 2021-12-01
CN-113996346-A Catalyst and application thereof in citral hydrogenation 2021-11-29
CN-114149356-A Preparation method of methyl indolcarbate compound 2021-11-18
CN-113980686-A Preparation method of cyclohexyl-containing lateral o-difluorobenzene liquid crystal compound 2021-10-25
CN-113717713-A InP quantum dot and preparation method and application thereof 2021-09-27
CN-113637477-A InP quantum dot, preparation method thereof, InP/ZnSe and InP/ZnSe/ZnS quantum dot 2021-08-20
CN-113637469-A Cadmium-free quantum dot and preparation method thereof 2021-08-19
CN-113512416-A Preparation method of Ga-doped water-soluble InP quantum dots 2021-07-27
CN-113248501-A CLY series compounds, preparation method thereof and application thereof in preparing medicines 2021-06-17

Literatures

PMID Publication Date Title Journal
20849869 2011-01-01 Synthesis and biological evaluation of some nitrogen containing steroidal heterocycles Steroids
19485352 2009-07-03 Fullerene derivatives incorporating phosphoramidous ylide and phosphoramidate: synthesis and property The Journal of organic chemistry
18808107 2008-10-20 Synthesis and characterization of the trihalophosphine compounds of ruthenium [RuX2(eta(6)-cymene)(PY3)] (X = Cl, Br, Y = F, Cl, Br) and the related PF2(NMe2) and P(NMe2)3 compounds; multinuclear NMR spectroscopy and the X-ray single crystal structures of [RuBr2(eta(6)-cymene)(PF3)], [RuBr2(eta(6)-cymene)(PF2{NMe2})], and [RuI2(eta(6)-cymene)(P{NMe2}3)] Inorganic chemistry
18604827 2008-09-01 Synthesis of bulky arylphosphanes by rhodium-catalyzed formal [2+2+2] cycloaddition reaction and their use as ligands Chemistry, an Asian journal
18362987 2008-04-01 BINOL-derived phosphoramidites in asymmetric hydrogenation: can the presence of a functionality in the amino group influence the catalytic outcome? Chemical Society reviews
17614326 2008-03-01 Sugar derived hexacoordinated phosphates: chiral anionic auxiliaries with general asymmetric efficiency Chirality
18642261 2008-01-01 BINOL-3,3'-triflone N,N-dimethyl phosphoramidites: through-space 19F,31P spin-spin coupling with a remarkable dependency on temperature and solvent internal pressure Chemistry (Weinheim an der Bergstrasse, Germany)
16402832 2006-01-18 Synthesis of transient and stable C-amino phosphorus ylides and their fragmentation into transient and stable carbenes Journal of the American Chemical Society
15106987 2004-05-03 Phosphorus-based p-tert-butylcalix[5]arene ligands Inorganic chemistry
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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