Propofol Impurity E

Catalog Number Size Price Stock Quantity
B1768-483430 500 mg $199 In stock
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Product Information

Molecular Formula:
C24H34O2
Molecular Weight:
354.54
Description
An impurity of Propofol.Propofol is a short-acting medication that results in a decreased level of consciousness and lack of memory for events. Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation.
Synonyms
3,3',5,5'-Tetrakis(1-methylethyl)-[1,1'-biphenyl]-4,4'-diol; 2,2',6,6'-Tetraisopropyl-p,p'-biphenol; 3,3',5,5'-Tetraisopropyl-4,4'-dihydroxybiphenyl; Propofol EP Impurity E; Dipropofol
IUPAC Name
4-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-2,6-di(propan-2-yl)phenol
Canonical SMILES
CC(C)C1=CC(=CC(=C1O)C(C)C)C2=CC(=C(C(=C2)C(C)C)O)C(C)C
InChI
InChI=1S/C24H34O2/c1-13(2)19-9-17(10-20(14(3)4)23(19)25)18-11-21(15(5)6)24(26)22(12-18)16(7)8/h9-16,25-26H,1-8H3
InChI Key
QAISRHCMPQROAX-UHFFFAOYSA-N
Melting Point
108-110°C
Purity
> 95%
Appearance
Yellow Solid
Storage
0-10°C

Computed Properties

XLogP3
7.3
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
5
Exact Mass
354.255880323 g/mol
Monoisotopic Mass
354.255880323 g/mol
Topological Polar Surface Area
40.5Ų
Heavy Atom Count
26
Formal Charge
0
Complexity
352
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-111960927-A Method for preparing 3,3',5,5' -tetraalkyl-4, 4' -biphenol by catalytic hydrogenation 2020-08-28
CN-113491680-A Application of catechol and derivatives in preparation of drugs for treating sleep disorders 2020-04-03
WO-2021196884-A1 Use of catechol and derivatives in preparation of drugs for treating sleep disturbances 2020-04-03
JP-2020143263-A Polyphenylene ethers, curable compositions, dry films, prepregs, cured products, laminates, and electronic components 2019-02-28
EP-3845517-A1 Gaba a receptor allosteric enhancer compound and preparation and use thereof 2018-08-31
US-2021315836-A1 Allosteric Enhancing Compound of GABAA Receptor and Preparation and Use Thereof 2018-08-31
US-2021171883-A1 Antiviral wiper 2018-08-29
TW-202007709-A Polyphenylene ether, hardenable composition containing polyphenylene ether, dry film, prepreg, hardened material, laminate, and electronic parts 2018-07-17
WO-2020017570-A1 Poly(phenylene ether), curable composition containing poly(phenylene ether), dry film, prepreg, cured object, laminate, and electronic component 2018-07-17
CN-112384552-A Polyphenylene ether, curable composition containing polyphenylene ether, dry film, prepreg, cured product, laminate, and electronic component 2018-07-17

Literatures

PMID Publication Date Title Journal
21709605 2011-08-15 Addition of a water-soluble propofol formulation to preservation solution in experimental kidney transplantation Transplantation
19231207 2009-04-15 Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols Bioorganic & medicinal chemistry
18670180 2008-08-01 [Antioxidant and antibacterial activities of dimeric phenol compounds] Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
17666822 2007-08-01 Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid Biological & pharmaceutical bulletin
16141558 2005-09-01 Mechanism of action of dipropofol and synergistic action with other antibacterial agents in vitro Biological & pharmaceutical bulletin
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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