TRIS(HYDROXYMETHYL)PHOSPHINE

Product Information

Molecular Formula:
C3H9O3P
Molecular Weight:
124.08
Description
TRIS(HYDROXYMETHYL)PHOSPHINE is a pivotal chemical entity applied in the biomedical sector. It possesses distinctive characteristics rendering it a potent reducing agent in diverse pharmaceutical drug syntheses. Furthermore, TRIS(HYDROXYMETHYL)PHOSPHINE assumes a paramount role in tackling specific ailments, including oxidative stress-linked disorders and neurodegenerative conditions.
Synonyms
PHOSPHINIDYNETRIMETHANOL; TRIS(HYDROXYMETHYL)PHOSPHINE; phosphinidynetri-methano; phosphinidynetris-methano; phosphinidynetrismethanol; trimethylolphosphine
IUPAC Name
bis(hydroxymethyl)phosphanylmethanol
Canonical SMILES
C(O)P(CO)CO
InChI
InChI=1S/C3H9O3P/c4-1-7(2-5)3-6/h4-6H,1-3H2
InChI Key
JMXMXKRNIYCNRV-UHFFFAOYSA-N
Boiling Point
111-113°C2.5 mm Hg(lit.)
Melting Point
48-56°C(lit.)
Flash Point
Not applicable
Purity
95%
Appearance
White powder or cryalline solids

Safety Information

Hazards
H301 - H315 - H318 - H335
Precautionary Statement
P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310

Computed Properties

XLogP3
-1.8
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
3
Exact Mass
124.02893114 g/mol
Monoisotopic Mass
124.02893114 g/mol
Topological Polar Surface Area
60.7Ų
Heavy Atom Count
7
Formal Charge
0
Complexity
31.7
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-113249371-A Preparation method and application of immobilized cells for tagatose production 2021-07-05
CN-113249371-B Preparation method and application of immobilized cells for tagatose production 2021-07-05
US-11220707-B1 Compositions and methods for pairwise sequencing 2021-06-17
US-11236388-B1 Compositions and methods for pairwise sequencing 2021-06-17
JP-2021050344-A Fabric care composition containing glyceride copolymer 2020-12-01
CN-113956425-A Reactive flame-retardant polyurethane foam containing phosphate ester structure and preparation method thereof 2020-09-17
WO-2022053769-A2 Fluorescent reporter and use thereof for the detection of target molecules 2020-09-11
EP-3964515-A1 High affinity macrocyclic fkb51-inhibitors for treatment of psychiatric disorders 2020-09-04
WO-2022049005-A1 High affinity macrocyclic fkb51-inhibitors for treatment of psychiatric disorders 2020-09-04
WO-2022003040-A1 Process for treating keratin fibers using particular amino acids in high concentration 2020-06-30

Literatures

PMID Publication Date Title Journal
21504026 2011-05-01 Assembly of collagen fibril meshes using gold nanoparticles functionalized with tris(hydroxymethyl)phosphine-alanine as multivalent cross-linking agents Journal of molecular recognition : JMR
21194623 2011-02-01 In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands Journal of inorganic biochemistry
21234407 2010-12-27 Potential Applications of Immobilized β-Galactosidase in Food Processing Industries Enzyme research
19164659 2009-02-01 Immobilization of recombinant thermostable beta-galactosidase from Bacillus stearothermophilus for lactose hydrolysis in milk Journal of dairy science
21201983 2008-03-05 Chloridotris[tris-(4-fluoro-phen-yl)phosphine]rhodium(I) methanol solvate Acta crystallographica. Section E, Structure reports online
18251492 2008-02-27 In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand Journal of medicinal chemistry
21201856 2008-02-08 trans-Carbonyl-chloridobis(tri-p-tolyl-phosphine)rhodium(I) acetone solvate Acta crystallographica. Section E, Structure reports online
18043951 2008-02-01 Synthesis, in vitro and in vivo characterization of (64)Cu(I) complexes derived from hydrophilic tris(hydroxymethyl)phosphane and 1,3,5-triaza-7-phosphaadamantane ligands Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
21200527 2007-12-12 trans-Carbonyl-chloridobis(ethyl-diphenyl-phosphine-κP)rhodium(I) Acta crystallographica. Section E, Structure reports online
17149861 2006-12-14 Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand Journal of medicinal chemistry
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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