Dithioerythritol
Product Information
Molecular Formula
C4H10O2S2
Molecular Weight
154.25
Description
Dithioerythritol is a potent reducing agent widely used in the biochemical field for its ability to break disulfide bonds in proteins, facilitating protein denaturation and analysis. Its role in maintaining the reduced state of thiol groups makes it indispensable in various laboratory applications, particularly in protein chemistry and molecular biology. The compound's stability and effectiveness under diverse conditions contribute to its frequent use in research settings. As a versatile reagent, dithioerythritol aids scientists in studying complex biochemical processes by ensuring accurate protein folding and structural studies.
Synonyms
1,4-Dithioerythritol; (2R,3S)-1,4-bis(sulfanyl)butane-2,3-diol;
IUPAC Name
(2R,3S)-1,4-bis(sulfanyl)butane-2,3-diol
SMILES
C(C(C(CS)O)O)S
InChI
1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+
InChI Key
VHJLVAABSRFDPM-ZXZARUISSA-N
Boiling Point
364.5°C at 760 mmHg
Melting Point
82-88 °C
Purity
≥98%
Density
1.302 g/cm3
Solubility
Soluble in DMSO
Appearance
White solid
Application
White crystals
Shelf Life
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Storage
Store at -20 °C
Refractive Index
1.5200 (estimate)
Safety Information
Hazards
H302+H312+H332:
Harmful if swallowed.
Harmful in contact with skin.
Harmful if inhaled.
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Harmful if swallowed.
Harmful in contact with skin.
Harmful if inhaled.
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P261:
Avoid breathing dust, fumes, gas, mist, vapours, spray. [As modified by IV ATP].
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352+P312:
IF ON SKIN:
Wash with plenty of soap and water.
Call a POISON CENTER or doctor/physician if you feel unwell.
P304+P340+P312:
IF INHALED:
Remove person to fresh air and keep comfortable for breathing.
Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
Avoid breathing dust, fumes, gas, mist, vapours, spray. [As modified by IV ATP].
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352+P312:
IF ON SKIN:
Wash with plenty of soap and water.
Call a POISON CENTER or doctor/physician if you feel unwell.
P304+P340+P312:
IF INHALED:
Remove person to fresh air and keep comfortable for breathing.
Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
Computed Properties
XLogP3
-0.4
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
3
Exact Mass
154.01222190 g/mol
Monoisotopic Mass
154.01222190 g/mol
Topological Polar Surface Area
42.5Ų
Heavy Atom Count
8
Formal Charge
0
Complexity
52
Isotope Atom Count
0
Defined Atom Stereocenter Count
2
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114113399-A | Ceftiofur detection method and application thereof | 2021-12-02 |
| CN-113777312-A | Preparation method of hepatitis B antibody fragment, kit and application | 2021-09-03 |
| CN-113683676-A | Environment-friendly reversible protein denaturation process | 2021-08-27 |
| CN-113528441-A | Rapid and efficient clinical-grade pigment epithelial cell induction method, kit and application | 2021-08-05 |
| CN-113564122-A | Method for differentiating human induced pluripotent stem cells into oligodendrocytes, kit and application | 2021-08-05 |
| CN-113209364-A | Polymer hydrogel with tissue light healing function and preparation and application thereof | 2021-05-14 |
| CN-113209364-B | Polymer hydrogel with tissue light healing function and preparation and application thereof | 2021-05-14 |
| CN-113278598-A | Biological enzyme system for preparing drug metabolites and application thereof | 2021-04-25 |
| JP-2021080483-A | Complex | 2021-03-04 |
| CN-113004377-A | Renaturation method of new coronavirus recombinant protein inclusion body | 2021-02-07 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 25849418 | 2015-05-18 | Mitochondrial carnitine/acylcarnitine transporter, a novel target of mercury toxicity | Chemical research in toxicology |
| 25490951 | 2015-03-01 | Functional and molecular effects of mercury compounds on the human OCTN1 cation transporter: C50 and C136 are the targets for potent inhibition | Toxicological sciences : an official journal of the Society of Toxicology |
| 23402788 | 2013-04-25 | Inhibition of mitochondrial carnitine/acylcarnitine transporter by H(2)O(2): molecular mechanism and possible implication in pathophysiology | Chemico-biological interactions |
| 22900493 | 2013-02-01 | Inhibition of the OCTN2 carnitine transporter by HgCl2 and methylmercury in the proteoliposome experimental model: insights in the mechanism of toxicity | Toxicology mechanisms and methods |
| 23010140 | 2012-11-15 | Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity | Toxicology and applied pharmacology |
| 23062438 | 2012-10-31 | Determination of biothiols by a novel on-line HPLC-DTNB assay with post-column detection | Analytica chimica acta |
| 22845804 | 2012-08-07 | Shift in the equilibrium between on and off states of the allosteric switch in Ras-GppNHp affected by small molecules and bulk solvent composition | Biochemistry |
| 21729133 | 2012-05-01 | Effects of curcumin and dithioerythritol on frozen-thawed bovine semen | Andrologia |
| 22378944 | 2012-05-01 | Two carbon fluxes to reserve starch in potato (Solanum tuberosum L.) tuber cells are closely interconnected but differently modulated by temperature | Journal of experimental botany |
| 22220568 | 2012-04-01 | Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase | The Biochemical journal |
