N-Lauroylsarcosine sodium salt

Sodium lauroyl sarcosinate (INCI), also known as sarkosyl, is an ionic surfactant derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products. In molecular biology experiments, sarkosyl is used to inhibit the initiation of DNA transcription.This surfactant is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate. Since the nitrogen atom is in an amide linkage, the nitrogen is not pH active and is neutrally charged in all aqueous solutions regardless of pH. The carboxylate has a pKa of about 3.6 and is therefore negatively charged in solutions of pH greater than about 5.5.pH-sensitive vesicles can be prepared using this surfactant with another cationic or water-insoluble amphiphiles such as 1-decanol.Addition of an mixture of equal parts of sodium lauroyl sarcosinate and the non-ionic surfactant sorbitan monolaurate (S20) to water led to the formation of micelle-like aggregates, even though neither surfactant formed micelles when present alone. Such aggregates can help carry other small molecules, such as drugs, through the skin.

N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL

sodium2-[dodecanoyl(methyl)amino]acetate

CCCCCCCCCCCC(=O)N(C)CC(=O)[O-].[Na+]

InChI=1S/C15H29NO3.Na/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)/q+1/p-1

KSAVQLQVUXSOCR-UHFFFAOYSA-M

100°C

140°C

94°C (30%)

95%

1.033 g/mL at 20 °C

water, 6490 mg/L @ 25 °C (est)

Clear liquid

Used as a detergent, foaming agent, and antienzyme for dentifrices; Permitted for use as an inert ingredient in non-food pesticide products; Sodium lauroyl sarcosinate (INCI), also known as sarkosyl, is an ionic surfactant derived from sarcosine, used as a foaming and cleansing agent in shampoo, shaving foam and foam wash products. In molecular biology experiments, sarkosyl is used to inhibit the initiation of DNA transcription.

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Stable. Incompatible with strong oxidizing agents.

2.11560

0.02 [mmHg]

H315:
Causes skin irritation.
H318:
Causes serious eye damage.
H330:
Fatal if inhaled.

P260:
Do not breathe dust, fumes, gas, mist, vapours, spray.
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340+P310:
IF INHALED:
Remove person to fresh air and keep comfortable for breathing.
Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338+P310:
IF IN EYES:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do. Continue rinsing.
Immediately call a POISON CENTER or doctor/physician.
P403+P233:
Store in a well ventilated place.
Keep container tightly closed.