C12E5
Product Information
Molecular Formula
C22H46O6
Molecular Weight
406.60
Description
C12E5 is a nonionic surfactant composed of a dodecyl hydrophobic chain and a pentaethylene glycol hydrophilic segment. Its amphiphilic structure supports solubilization and organization of hydrophobic and aqueous components in formulation, membrane-model, and physicochemical studies.
As a surfactant, its performance is governed by concentration, temperature, medium composition, and the properties of the material being solubilized. It is used primarily in surfactant, solubilization, formulation, and physicochemical studies where amphiphilic behavior is required.
Synonyms
Pentaethylene glycol monododecyl ether; Dodecyl pentaethylene glycolether; n-Dodecylpentaoxyethylene; Laureth-5; Pentaethylene glycol lauryl ether; Pentaoxyethylene monododecyl ether; Polyoxyethylene (5) lauryl ether; PEG-5 Lauryl ether; 3,6,9,12,15-Pentaoxaheptacosan-1-ol
IUPAC Name
2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
SMILES
CCCCCCCCCCCCOCCOCCOCCOCCOCCO
InChI
InChI=1S/C22H46O6/c1-2-3-4-5-6-7-8-9-10-11-13-24-15-17-26-19-21-28-22-20-27-18-16-25-14-12-23/h23H,2-22H2,1H3
InChI Key
LAPRIVJANDLWOK-UHFFFAOYSA-N
Boiling Point
486.6±35.0°C at 760 mmHg
Melting Point
14.5-15.0°C
Flash Point
248.1°C
Purity
≥95%
Density
0.963 g/mL at 20°C
Appearance
White to Light yellow powder to lump
Application
Non-ionic surfactant.
Storage
Store at -20°C
Stability
Stable. Flammable. Incompatible with strong oxidizing agents.
Computed Properties
XLogP3
4.5
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Rotatable Bond Count
25
Exact Mass
406.32943918 g/mol
Monoisotopic Mass
406.32943918 g/mol
Topological Polar Surface Area
66.4Ų
Heavy Atom Count
28
Formal Charge
0
Complexity
265
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-113768846-A | Nourishing anti-dandruff shampoo and preparation method thereof | 2021-10-26 |
| KR-102313788-B1 | Detergent Composition for removing Scale and Rust of Heat Exchanger | 2021-08-31 |
| EP-3818972-A2 | Piroctone olamine granules for use in cosmetic compositions | 2021-01-29 |
| KR-102242940-B1 | Method for preparing a non-reducing cleaning composition containing vegetable extracts and a non-reducing cleaning composition prepared thereby | 2021-01-19 |
| CN-112587454-A | Anti-allergic oriental cherry refreshing shampoo and preparation method thereof | 2020-12-23 |
| WO-2022056484-A1 | Method of treating amyloidosis | 2020-09-14 |
| US-2022071857-A1 | Dissolvable solid article containing anti-bacterial actives | 2020-09-10 |
| WO-2022053140-A1 | Surfactant containing formulation of pseudo-ceramides | 2020-09-10 |
| WO-2022056524-A1 | Dissolvable solid article containing anti-bacterial actives | 2020-09-10 |
| WO-2022053784-A1 | Crystalline form iii of tetraacetylethylenediamine | 2020-09-09 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 21981373 | 2011-12-06 | Sphere-to-rod transitions of nonionic surfactant micelles in aqueous solution modeled by molecular dynamics simulations | Langmuir : the ACS journal of surfaces and colloids |
| 18825291 | 2008-10-21 | Segmental order parameters in a nonionic surfactant lamellar phase studied with 1H-13C solid-state NMR | Physical chemistry chemical physics : PCCP |
| 18307365 | 2008-04-01 | Phase behavior and microstructure of C12E5 nonionic microemulsions with chlorinated oils | Langmuir : the ACS journal of surfaces and colloids |
| 17979395 | 2007-10-28 | Effect of cholesterol on diffusion in surfactant bilayers | The Journal of chemical physics |
| 17302467 | 2007-02-07 | Atomic force microscopy images of lyotropic lamellar phases | The Journal of chemical physics |
| 16293237 | 2006-01-01 | Thermotropic phase behaviour of the pseudobinary mixtures of DPPC/C12E5 and DMPC/C12E5 determined by differential scanning calorimetry and ultrasonic velocimetry | Chemistry and physics of lipids |
| 15450466 | 2004-10-15 | Study of mixtures of n-dodecyl-beta-D-maltoside with anionic, cationic, and nonionic surfactant in aqueous solutions using surface tension and fluorescence techniques | Journal of colloid and interface science |
| 14724754 | 2003-11-01 | The Ca(2+)-ATPase of the scallop sarcoplasmic reticulum is of a cold-adapted type | The Journal of membrane biology |
| 12755586 | 2003-05-01 | Structure elucidation, synthesis, and contact allergenic activity of a major hydroperoxide formed at autoxidation of the ethoxylated surfactant C12E5 | Chemical research in toxicology |
| 12484925 | 2002-12-16 | Topological transition in aqueous nonionic micellar solutions | Physical review letters |
