L-Lactide homopolymer
Product Information
Description
Lactide is a member of dioxanes.
Synonyms
1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3S,6S)-, homopolymer; 1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3S-cis)-, homopolymer; p-Dioxane-2,5-dione, 3,6-dimethyl-, (S,S)-, polyesters; Poly-L-lactide; L-Lactide polymer
IUPAC Name
3,6-dimethyl-1,4-dioxane-2,5-dione
SMILES
CC1C(=O)OC(C(=O)O1)C
InChI
InChI=1S/C6H8O4/c1-3-5(7)10-4(2)6(8)9-3/h3-4H,1-2H3/t3-,4-/m0/s1
InChI Key
JJTUDXZGHPGLLC-IMJSIDKUSA-N
Boiling Point
285.5°C at 760 mmHg
Melting Point
153 °C
Flash Point
150.6°C
Density
1.27 g/cm3
Application
Used to make polylactic acid and cosmetics.
Storage
-20°C
Refractive Index
1.429
Tg
60-65°C
LogP
-0.13660
Safety Information
Hazards
Harmless-use normal precautions. Hygroscopic
Handling
Exercise normal care
| Molecular Weight | Viscosity | Description |
|---|---|---|
| Mw~700,000 | 5.70 - 8.20 dL/g (25°C; CHCl3. 0.1 g/dL) | Poly(L-lactide) (PLLA) is a biodegradable polymer for medical device and pharmaceutical applications. It is used to fabricate resorbable medical devices that degrade over months in physiological conditions. Due to their history, polylactides are one of the easiest and most affordable biodegradable polymers for medical devices. |
| Mw~1,600-2,400 | 0.10 - 0.20 dL/g (25°C; CHCl3. 1.0 g/dL) | Poly(L-lactide) (PLLA) is a biodegradable polymer for medical device and pharmaceutical applications. It is used to fabricate resorbable medical devices that degrade over months in physiological conditions. Due to their history, polylactides are one of the easiest and most affordable biodegradable polymers for medical devices. |
| Mw~80,000-100,000 | 1.50 - 2.00 dL/g (25°C; CHCl3. 0.1 g/dL) | Poly(L-lactide) (PLLA) is a biodegradable polymer for medical device and pharmaceutical applications. It is used to fabricate resorbable medical devices that degrade over months in physiological conditions. Due to their history, polylactides are one of the easiest and most affordable biodegradable polymers for medical devices. |
| Mw 40,000~70,000 | 0.90 - 1.20 dL/g (25°C; CHCl3. 0.1 g/dL) | Poly(L-lactide) (PLLA) is a biodegradable polymer for medical device and pharmaceutical applications. It is used to fabricate resorbable medical devices that degrade over months in physiological conditions. Due to their history, polylactides are one of the easiest and most affordable biodegradable polymers for medical devices. |
| Mw~325,000-460,000 | 4.3 - 5.5 dL/g (25°C; CHCl3l. 0.1 g/dL) | Poly(L-lactide) (PLLA) is a biodegradable polymer for medical device and pharmaceutical applications. It is used to fabricate resorbable medical devices that degrade over months in physiological conditions. Due to their history, polylactides are one of the easiest and most affordable biodegradable polymers for medical devices. |
Computed Properties
XLogP3
0.6
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
0
Exact Mass
144.04225873 g/mol
Monoisotopic Mass
144.04225873 g/mol
Topological Polar Surface Area
52.6Ų
Heavy Atom Count
10
Formal Charge
0
Complexity
155
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
2
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2021188799-A1 | Synthesis method and device for rapidly producing lactide at high yield | 2021-03-04 |
| US-10959969-B1 | Methods of treating SARS Cov-2 virus with protocatechuic acid | 2020-07-24 |
| US-2021186491-A1 | Suture packages having integrated suture straightening assemblies | 2019-12-24 |
| EP-3839043-A1 | Screening methods for compounds modulating polyamine transport | 2019-12-20 |
| WO-2021121412-A1 | Leadless pacemaker and tail end component and head end component thereof | 2019-12-20 |
| WO-2021123655-A1 | Method for manufacturing a polyester containing at least one 1,4:3,6-dianhydrohexitol unit with reduced colouring and improved rates of incorporation of the unit(s) | 2019-12-20 |
| WO-2021124301-A1 | Formulations and method for treatment of inflammatory diseases | 2019-12-20 |
| WO-2021125236-A1 | Biaxially oriented polyester film and method for producing same | 2019-12-20 |
| EP-3838976-A1 | Process for degrading plastic products | 2019-12-19 |
| WO-2021119727-A1 | Biocompatible material | 2019-12-19 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22088756 | 2012-11-01 | Poly (N-isopropylacrylamide)-PLA and PLA blend nanoparticles for temperature-controllable drug release and intracellular uptake | Colloids and surfaces. B, Biointerfaces |
| 22961054 | 2012-10-28 | Alkaline earth metal complexes of a chiral polyether as initiator for the ring-opening polymerization of lactide | Dalton transactions (Cambridge, England : 2003) |
| 22968601 | 2012-10-25 | Nacnac(Bn)CuOiPr: a strained geometry resulting in very high lactide polymerization activity | Chemical communications (Cambridge, England) |
| 23016983 | 2012-10-24 | Tandem metal-coordination copolymerization and organocatalytic ring-opening polymerization via water to synthesize diblock copolymers of styrene oxide/CO2 and lactide | Journal of the American Chemical Society |
| 23009063 | 2012-10-15 | Stereoselective synthesis of biphenolate/binaphtolate titanate and zirconate alkoxide species: structural characterization and use in the controlled ROP of lactide | Inorganic chemistry |
| 23030249 | 2012-10-15 | Synthesis and characterization of amine-bridged bis(phenolate)lanthanide alkoxides and their application in the controlled polymerization of rac-lactide and rac-β-butyrolactone | Inorganic chemistry |
| 22903466 | 2012-10-14 | Dimethylaluminium aldiminophenolates: synthesis, characterization and ring-opening polymerization behavior towards lactides | Dalton transactions (Cambridge, England : 2003) |
| 22561339 | 2012-10-10 | Dual-purpose magnetic micelles for MRI and gene delivery | Journal of controlled release : official journal of the Controlled Release Society |
| 22930321 | 2012-10-09 | Highly heteroselective ring-opening polymerization of racemic lactide initiated by divalent ytterbium complexes bearing amino bis(phenolate) ligands | Chemical communications (Cambridge, England) |
| 22892614 | 2012-10-07 | Al and Zn complexes bearing N,N,N-tridentate quinolinyl anilido-imine ligands: synthesis, characterization and catalysis in L-lactide polymerization | Dalton transactions (Cambridge, England : 2003) |
