4-Hydroxybenzophenone
Product Information
Molecular Formula
C13H10O2
Molecular Weight
198.22
Description
4-Hydroxybenzophenone is a member of benzophenones.
Synonyms
Methanone, (4-hydroxyphenyl)phenyl-; (4-Hydroxyphenyl)phenylmethanone; Benzophenone, 4-hydroxy-; Benzophenone, p-hydroxy-; 1-(4-Hydroxyphenyl)-1-phenylmethanone; 4-Benzoylphenol; 4-Hydroxyphenyl phenyl ketone; 4'-Hydroxybenzophenone; N-(4-Hydroxylphenyl)-N'-phenylurea; NSC 1887; p-Benzoylphenol; p-Hydroxybenzophenone
IUPAC Name
(4-hydroxyphenyl)-phenylmethanone
SMILES
C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)O
InChI
InChI=1S/C13H10O2/c14-12-8-6-11(7-9-12)13(15)10-4-2-1-3-5-10/h1-9,14H
InChI Key
NPFYZDNDJHZQKY-UHFFFAOYSA-N
Boiling Point
150-160°C
Melting Point
132-135°C
Flash Point
235.4 °F
Purity
≥95%
Density
1.194±0.06 g/cm3
Solubility
Soluble in Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
Appearance
white to beige fine crystalline powder
Storage
Store at 2-8°C
Safety Information
Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Signal Word
Warning
Computed Properties
XLogP3
3.1
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
2
Exact Mass
198.068079557 g/mol
Monoisotopic Mass
198.068079557 g/mol
Topological Polar Surface Area
37.3Ų
Heavy Atom Count
15
Formal Charge
0
Complexity
211
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114163550-A | Multifunctional macromolecular photoinitiator and preparation method thereof | 2021-12-14 |
| CN-114106219-A | Nano composite initiator, thickening agent for fracturing fluid and application of thickening agent | 2021-12-09 |
| CN-114149311-A | Method for preparing 4-hydroxybenzophenone compound by taking p-methylenequinone as substrate | 2021-12-08 |
| CN-114106234-A | Preparation method and application of ultraviolet-curable acrylic copolymer | 2021-11-29 |
| CN-114057790-A | Preparation method of vitamin A triphenylphosphine salt with high all-trans isomer content | 2021-11-18 |
| CN-113845694-A | Modification method of expanded polytetrafluoroethylene, product, proton exchange membrane and membrane electrode | 2021-11-12 |
| CN-113881005-A | Polymer, preparation method and application thereof, and substrate coated with polymer on surface | 2021-11-12 |
| CN-114133334-A | Industrial preparation process of tamoxifen citrate | 2021-11-09 |
| CN-113773265-A | Fluorescent probe for detecting CYP450, preparation method and application thereof | 2021-10-25 |
| CN-113912857-A | Photochromic coordination polymer and preparation method and application thereof | 2021-10-22 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 35476924 | 2022-08-01 | 4-hydroxybenzophenone exposure inhibits mouse hippocampal neural stem cell proliferation in vitro by upregulating Cxcl1 | Toxicology in vitro : an international journal published in association with BIBRA |
| 30245359 | 2018-12-01 | Urinary excretion of phenols, parabens and benzophenones in young men: Associations to reproductive hormones and semen quality are modified by mutations in the Filaggrin gene | Environment international |
| 22959206 | 2012-10-01 | Design, synthesis and identification of a new class of triarylmethyl amine compounds as inhibitors of apolipoprotein E production | Bioorganic & medicinal chemistry letters |
| 22417702 | 2012-04-17 | Urinary concentrations of benzophenone-type UV filters in U.S. women and their association with endometriosis | Environmental science & technology |
| 22452412 | 2012-04-12 | Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein | Journal of medicinal chemistry |
| 22334775 | 2012-01-01 | Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells | International journal of nanomedicine |
| 21872029 | 2011-09-30 | Determination of benzophenones in human placental tissue samples by liquid chromatography-tandem mass spectrometry | Talanta |
| 21530995 | 2011-08-01 | Occurrence of multiclass UV filters in treated sewage sludge from wastewater treatment plants | Chemosphere |
| 21480589 | 2011-05-01 | Determination of benzotriazole and benzophenone UV filters in sediment and sewage sludge | Environmental science & technology |
| 21853132 | 2011-01-01 | Metabolomics-driven nutraceutical evaluation of diverse green tea cultivars | PloS one |
