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Polyurethane Scaffold Preparation

Polyurethane (PU) scaffolds are synthetic materials that serve as biocompatible scaffolds for small-diameter, low-flow blood vessels. They feature alternating hard and soft segments, combining flexibility with tensile strength. Compared to other synthetic materials, PU scaffolds reduce vascular hyperplasia and promote endothelialization, making them highly valued in tissue regeneration. Currently, PU scaffolds have been applied to the engineering of bone, blood vessels, myocardium, heart valves, skin, and cartilage. BOC Sciences offers professional polyurethane scaffold preparation services, dedicated to providing high-quality, customizable 3D scaffolds for tissue engineering, regenerative medicine, and drug delivery development. We integrate multiple advanced fabrication techniques, including solvent casting, thermally induced phase separation (TIPS), gas foaming, electrospinning, and 3D printing, ensuring complete control over pore structure, mechanical properties, and degradation characteristics. Additionally, our services support functional modification and composite material development to meet diverse applications in soft tissue, hard tissue, and drug delivery, enabling efficient translation from research to product development.

What We Offer

Enhance Regenerative Medicine Projects with PU Scaffolds

BOC Sciences offers a wide range of polyurethane scaffolds, from degradable to non-degradable, and from uniform porous to gradient pore and nanofiber structures, meeting diverse applications from soft to hard tissues. Whether for functional drug carriers, cell culture scaffolds, or customized biomimetic material development, we provide end-to-end fabrication, optimization, and analytical services, helping clients efficiently achieve their research and product development goals.

Degradable Polyurethane Scaffolds

  • Support in vivo enzymatic or hydrolytic degradation, with controllable degradation rates to match tissue repair cycles.
  • Customizable soft/hard segment ratios to balance mechanical performance and degradation.
  • Capable of loading drugs or growth factors for functional controlled release.
  • Development services from small-scale to pilot-scale production, suitable for preclinical studies.

Non-Degradable Polyurethane Scaffolds

  • Provide high-strength, long-term stable scaffolds for soft and hard tissue support.
  • Elasticity and rigidity adjustable according to vascular, myocardial, or bone tissue requirements.
  • Scaffold surfaces can be optimized for cell adhesion and bioactivity.
  • Support 3D printing and custom fabrication of complex scaffold structures.

Uniform Porous Scaffolds

  • Customizable pore sizes (tens to hundreds of microns) to support various cell types.
  • Controlled porosity via solvent casting or gas foaming processes.
  • Supports surface modification and functionalization.
  • Suitable for bone, cartilage, and in vitro tissue culture models.

Gradient Pore Scaffolds

  • Pore sizes gradually change from surface to interior, mimicking natural tissue architecture.
  • Customizable composite scaffolds for soft-hard tissue interfaces.
  • Fabrication via 3D printing or thermally induced phase separation.
  • Capable of gradient loading of drugs or growth factors to promote zonal tissue regeneration.

Nanofiber/Microporous Scaffolds

  • Electrospun fiber scaffolds mimicking extracellular matrix structure.
  • Supports embedding of nanoparticles or composite materials to enhance bioactivity and mechanical properties.
  • Applicable for soft tissue engineering, vascular, and skin repair.
  • Surface functionalization available to enhance cell adhesion and growth.

Looking for Biomimetic Material Solutions?

From natural polymers to bio-inspired composites, BOC Sciences provides customized materials to accelerate your research and industrial applications.

Services

High-Quality Polyurethane Scaffold Services Tailored to You

BOC Sciences understands the diverse needs of research and industrial clients in polyurethane scaffold development and provides comprehensive services covering fabrication, functionalization, analytical characterization, and customized development. Our expert team is proficient in designing and controlling various polyurethane chemistries and mastering multiple advanced fabrication techniques. Through BOC Sciences' polyurethane scaffold services, clients can customize pore structure, mechanical properties, and degradation rates according to specific application requirements, achieving seamless integration from basic research to industrial production.

1Polyurethane Scaffold Fabrication Services

We offer multiple fabrication methods to ensure scaffold pore structure, mechanical performance, and functional requirements meet client needs:

  • Solvent Casting and Particulate Leaching (SCPL): Suitable for high-porosity scaffolds with tunable pore sizes, supporting various particle templates.
  • Thermally Induced Phase Separation (TIPS): Produces uniform porous structures, ideal for cartilage and bone tissue engineering scaffolds.
  • Gas Foaming: Uses supercritical CO₂ or foaming agents to form porous scaffolds with no solvent residues and excellent pore interconnectivity.
  • Electrospinning: Produces nano- or micro-fiber network structures with high biomimicry, promoting cell adhesion and tissue regeneration.
  • 3D Printing/Additive Manufacturing: Precisely controls scaffold 3D structure and pore distribution, enabling personalized customization.

2Polyurethane Scaffold Analysis and Characterization Services

BOC Sciences provides rigorous material analysis and characterization to ensure reliable scaffold quality and performance:

  • Pore Structure Analysis: SEM and Micro-CT to evaluate pore size and porosity.
  • Mechanical Testing: Tensile, compressive, and shear tests to verify scaffold mechanical performance.
  • Degradation Testing: In vitro hydrolysis and enzymatic degradation experiments to predict in vivo behavior.
  • Surface Chemistry Analysis: FTIR and XPS to assess surface modification efficiency.

3Polyurethane Scaffold Functionalization Services

  • Surface Modification: Introduce amino acids, proteins, polysaccharides, or growth factors to improve bioactivity and cell adhesion.
  • Drug Loading: Incorporate drugs, antibodies, or growth factors into scaffolds for localized controlled release.
  • Nanocomposite Functionalization: Combine nanoparticles or inorganic materials like hydroxyapatite to enhance mechanical properties and bioactivity.

4Customized Development Services

  • Personalized Scaffold Design: Customize pore size, porosity, mechanical performance, and degradation rates according to client requirements.
  • Scale-Up Support: From laboratory-scale preparation to pilot and industrial production.
  • Multi-Material Composite Scaffold Development: Combine polyurethane with natural polymers or inorganic materials to optimize mechanical and biological performance.
Advantages

Technical Advantages of BOC Sciences Polyurethane Scaffolds

  • Materials Expertise: Extensive polyurethane chemistry knowledge and material library to select appropriate monomers, chain extenders, and modification strategies.
  • Fabrication Process Expertise: Proficient in SCPL, TIPS, electrospinning, gas foaming, and 3D printing to ensure controllable structure, interconnectivity, and mechanical stability.
  • Analysis and Characterization: Advanced SEM, Micro-CT, FTIR, XPS, and mechanical testing equipment for comprehensive and precise scaffold performance evaluation.
  • Functionalization Capability: Surface modification, drug loading, and composite development services to meet cell adhesion, controlled release, and biomimetic requirements.
  • Full-Process Development Support: Guidance from small-scale trials to pilot and mass production, enabling lab-to-industrial translation.
  • Wide Application Range: Covers soft tissue, hard tissue, drug delivery, and in vitro tissue models for diverse research and industrial needs.
  • Professional Client Support: Technical consultation, customized design, and after-sales support to ensure smooth project execution and rapid achievement of research or product goals.
Service Process

Custom Polyurethane Scaffold Service Process Explained

BOC Sciences offers end-to-end services for polyurethane scaffold development, from concept design to functionalized scaffold delivery, ensuring each step is precise, efficient, and controllable. Whether for research projects, preclinical development, or industrial-scale production, our professional team provides customized solutions to help clients rapidly achieve scaffold fabrication, functional optimization, and practical application.

Requirement Communication and Solution Design

1Requirement Communication and Solution Design

We engage in in-depth discussions with clients to clarify research goals, tissue types, and functional requirements, proposing feasible solutions tailored to scaffold applications. For soft tissue, hard tissue, or drug delivery needs, we design pore structures, mechanical properties, and degradation rates, while offering preliminary material selection guidance to ensure both research feasibility and industrial scalability.

Material Selection and Performance Optimization

2Material Selection and Performance Optimization

Based on scaffold mechanical performance, biocompatibility, and degradation characteristics, we select suitable polyurethane monomers, chain extenders, and soft/hard segment ratios. Material combinations can be optimized for specific applications, such as increased elasticity for vascular scaffolds or enhanced rigidity for bone repair scaffolds. We also provide physicochemical analysis to ensure scientific and reliable material selection.

Scaffold Fabrication and Process Development

3Scaffold Fabrication and Process Development

We master multiple fabrication techniques, including solvent casting, thermally induced phase separation (TIPS), gas foaming, electrospinning, and 3D printing, ensuring control over scaffold porosity, pore size, and structure. Processes can be developed for small-scale, pilot-scale, and industrial production, maintaining stable, reproducible fabrication while optimizing methods to meet diverse tissue engineering and drug carrier applications.

Functionalization and Composite Material Development

4Functionalization and Composite Material Development

We provide scaffold functionalization services tailored to specific applications, such as surface modification to enhance cell adhesion, drug or growth factor loading for controlled release, or embedding nanoparticles and inorganic materials to improve mechanical performance and bioactivity. Functional designs can be flexibly combined, ensuring each scaffold offers both physical support and biological or drug delivery functionality.

Analysis, Characterization, and Quality Assessment

5Analysis, Characterization, and Quality Assessment

Completed polyurethane scaffolds undergo comprehensive analysis, including SEM observation of pore structures, Micro-CT assessment of 3D pore interconnectivity, mechanical performance testing, degradation evaluation, and surface chemistry characterization (FTIR, XPS, etc.). Strict quality assessments ensure scaffolds meet client design requirements for pore structure, mechanical strength, degradation rate, and functionalization efficacy.

Delivery and Technical Support

6Delivery and Technical Support

We provide fully documented scaffold products along with detailed technical reports, including porosity, mechanical properties, surface modification, and degradation data. Post-delivery, we continue to offer technical consultation and experimental optimization guidance, assisting clients in research, preclinical studies, or industrial production to ensure polyurethane scaffolds achieve optimal performance in their intended applications.

Applications

Explore Polyurethane Scaffold Applications in Tissue Repair and Regeneration

With excellent mechanical properties, tunable pore structures, and good biocompatibility, polyurethane scaffolds have become essential materials in tissue engineering, regenerative medicine, and drug delivery. They provide ideal 3D support and functional platforms for soft tissue repair, hard tissue regeneration, drug delivery, and in vitro 3D tissue model construction, meeting diverse research and preclinical study needs.

Soft Tissue Engineering

Polyurethane scaffolds are widely applied in soft tissue repair, providing three-dimensional support for cell growth and promoting tissue regeneration.

  • Skin Regeneration: PU scaffolds can be used for wound coverage, burn or skin defect repair, offering adjustable porosity and elasticity to promote keratinocyte and fibroblast adhesion, growth, and differentiation, accelerating skin repair and wound healing.
  • Vascular Repair: PU scaffolds can be fabricated into artificial vessels or vascular stents, providing elastic support, mimicking the endothelium, supporting endothelial cell spreading and vessel regeneration, and enabling drug functionalization for anticoagulant or local controlled release.
  • Cardiac Tissue Engineering: Used for myocardial defect repair or cardiac regeneration research, PU scaffolds simulate myocardial elasticity and conductivity, supporting cardiomyocytes, enhancing tissue repair, and accommodating growth factors or electrical stimulation functions.

Hard Tissue Engineering

PU scaffolds demonstrate excellent mechanical support and bioactivity in bone and dental tissue repair.

  • Bone Repair: Scaffolds fill bone defects, promoting osteocyte adhesion and proliferation through porous structures. Composite with hydroxyapatite or tricalcium phosphate enhances osteoinductivity and mechanical support, facilitating new bone formation.
  • Dental Applications: Used for periodontal tissue regeneration and alveolar bone defect repair, scaffolds co-cultured with osteoblasts mimic the alveolar bone microenvironment, promoting bone regeneration and periodontal soft tissue repair.
  • Articular Cartilage Repair: With gradient pore structures and tunable degradability, PU scaffolds can fill cartilage defects and support joint repair, providing optimal environments for chondrocyte growth and improving joint function.

Drug Delivery

PU scaffolds serve as efficient drug carriers. Their porous structure and degradable nature enable precise drug delivery and controlled release.

  • Sustained-Release Drug Carriers: Scaffold porosity and degradation rates allow continuous release of drugs, proteins, or growth factors, reducing dosing frequency and improving therapeutic outcomes.
  • Gene Therapy Platforms: PU scaffolds can carry nucleic acids or viral vectors for localized gene delivery, providing 3D support and controlled release to enhance gene therapy efficacy.
  • Anti-Cancer and Antimicrobial Applications: Chemotherapeutics or antimicrobial agents can be loaded into scaffolds for targeted local release, reducing systemic side effects while supporting tissue repair.

Tissue Models and In Vitro Research

PU scaffolds provide realistic 3D microenvironments for in vitro experiments and tissue model research, serving as essential tools for drug screening and disease model development.

  • 3D Cell Culture Models: Scaffolds simulate in vivo tissue architecture, supporting 3D growth of stem cells, fibroblasts, or tumor cells, improving accuracy in cell function and behavior studies.
  • Disease Model Construction: Scaffolds enable in vitro models for cancer, cardiovascular disease, or bone defects, supporting drug screening and pathological mechanism research, enhancing reproducibility and clinical relevance.
  • Biomimetic Tissue Research: Functionalized scaffolds mimic the extracellular matrix environment, providing foundational data for tissue engineering and regenerative medicine research, supporting future clinical applications.
FAQs

Frequently Asked Questions

What is a polyurethane scaffold?

A polyurethane scaffold is a biocompatible, porous structure used in tissue engineering. It supports cell attachment, proliferation, and differentiation. With tunable mechanical properties, polyurethane scaffolds are ideal for regenerative medicine, soft tissue repair, bone regeneration, and drug delivery applications. Their versatility makes them widely used in biomedical research.

How are polyurethane scaffolds manufactured?

Polyurethane scaffolds can be fabricated using electrospinning, 3D printing, solvent casting, or freeze-drying. These methods allow precise control over pore size, structure, and mechanical strength. Advanced manufacturing ensures scaffolds mimic natural tissue environments, promoting cell growth and tissue integration, making them suitable for both clinical applications and laboratory research.

What are the main applications of polyurethane scaffolds?

Polyurethane scaffolds are used in soft tissue engineering, bone regeneration, wound healing, and cartilage repair. They serve as carriers for drug delivery and support stem cell proliferation. Their customizable porosity, mechanical strength, and biodegradability make polyurethane scaffolds versatile for regenerative medicine, biomedical devices, and laboratory tissue engineering research.

Are polyurethane scaffolds biocompatible and safe?

Yes, polyurethane scaffolds are highly biocompatible and safe for medical applications. They promote cell adhesion, growth, and differentiation without significant immune reactions. Chemical modifications can enhance biodegradability and mechanical properties, making these scaffolds suitable for long-term implants, tissue engineering, and other regenerative medicine applications.

How do polyurethane scaffolds promote tissue regeneration?

Polyurethane scaffolds provide a porous, 3D structure that mimics the extracellular matrix. This environment supports cell attachment, proliferation, and differentiation. Their mechanical strength and flexibility aid tissue formation while allowing nutrient and waste exchange. Surface modifications can further improve cell interactions, enhancing outcomes in bone, cartilage, and soft tissue regeneration.

Can polyurethane scaffolds be customized?

Yes, polyurethane scaffolds can be tailored for specific applications. Parameters like porosity, shape, mechanical strength, and degradation rate can be adjusted during fabrication. Functionalization with bioactive molecules or growth factors further enhances their regenerative capabilities. Customized polyurethane scaffolds are widely used in research, implantable devices, and advanced tissue engineering therapies.

What are the advantages of using polyurethane scaffolds in biomedical research?

Polyurethane scaffolds offer excellent flexibility, tunable mechanical properties, and biocompatibility. They support cell growth, tissue formation, and drug delivery studies. Their adaptability allows researchers to design scaffolds for soft tissue, bone, and cartilage engineering, making polyurethane scaffolds a preferred material in regenerative medicine and experimental tissue engineering.

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