Poly--benzyl-L-glutamate
Product Information
Molecular Formula
C12H15NO4
Molecular Weight
237.25200
Description
Poly--benzyl-L-glutamate is a highly versatile biopolymer. It finds immense utility in the field of biomedicine as an ingenious drug delivery system that enhances the efficacy of diverse medications. Notably, its exceptional efficiency in conveying anti-cancer pharmaceuticals, including paclitaxel, to specifically pinpointed tumor cells promises to revolutionize cancer therapeutics. Moreover, this remarkable biopolymer exhibits remarkable potential in treating neurodegenerative disorders by efficiently transporting neuroprotective compounds to the afflicted regions.
Synonyms
PBLG
IUPAC Name
2-amino-5-oxo-5-phenylmethoxypentanoic acid
SMILES
C1=CC=C(C=C1)COC(=O)CCC(C(=O)O)N
InChI
InChI=1S/C12H15NO4/c13-10(12(15)16)6-7-11(14)17-8-9-4-2-1-3-5-9/h1-5,10H,6-8,13H2,(H,15,16)
InChI Key
BGGHCRNCRWQABU-UHFFFAOYSA-N
Boiling Point
426.1°C at 760mmHg
Flash Point
Not applicable
Purity
95%
Density
1.245g/cm3
Storage
-20°C
Computed Properties
XLogP3
-1.7
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Rotatable Bond Count
7
Exact Mass
237.10010796 g/mol
Monoisotopic Mass
237.10010796 g/mol
Topological Polar Surface Area
89.6Ų
Heavy Atom Count
17
Formal Charge
0
Complexity
261
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2020264187-A1 | Compounds and methods for treating cancer, viral infections, and allergic conditions | 2019-06-25 |
| US-2021155752-A1 | Strong base-initiated n-carboxyanydride rapid ring-opening polymerisation method | 2018-06-14 |
| WO-2019152688-A1 | Spiro-lactam nmda receptor modulators and uses thereof | 2018-01-31 |
| EP-3740212-A2 | Conjugate based systems for controlled insulin delivery | 2017-12-18 |
| WO-2018096853-A1 | Novel medoxomil and hemiacetal esters of pemetrexed, production method therefor, and pharmaceutical composition containing ester prodrug | 2016-11-25 |
| US-10441607-B1 | Multifunctional linker technology containing an N4 group | 2016-02-22 |
| EP-3389643-A1 | Novel muramyl peptide derivative compound, synthesis and uses thereof | 2015-12-15 |
| US-10576147-B2 | Muramyl peptide derivative compound, synthesis and uses thereof | 2015-12-15 |
| US-2018360957-A1 | Novel muramyl peptide derivative compound, synthesis and uses thereof | 2015-12-15 |
| WO-2017103944-A1 | Novel muramyl peptide derivative compound, synthesis and uses thereof | 2015-12-15 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 23013452 | 2012-10-17 | Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition | Journal of the American Chemical Society |
| 22226894 | 2012-02-01 | Selective double quantum resolved correlation experiment for the complete separation of entire proton NMR spectra of enantiomers | Journal of magnetic resonance (San Diego, Calif. : 1997) |
| 22048006 | 2012-01-01 | Precipitation of nanohydroxyapatite on PLLA/PBLG/Collagen nanofibrous structures for the differentiation of adipose derived stem cells to osteogenic lineage | Biomaterials |
| 21698603 | 2011-11-01 | Synthesis and characterization of surface-modified PBLG nanoparticles for bone targeting: in vitro and in vivo evaluations | Journal of pharmaceutical sciences |
| 21899345 | 2011-10-19 | Bioreducible block copolymers based on poly(ethylene glycol) and poly(γ-benzyl L-glutamate) for intracellular delivery of camptothecin | Bioconjugate chemistry |
| 21476759 | 2011-04-07 | Enantiotopic discrimination in the deuterium NMR spectrum of solutes with S4 symmetry in chiral liquid crystals | The Journal of chemical physics |
| 21373811 | 2011-04-01 | Glycyrrhetinic acid-functionalized degradable micelles as liver-targeted drug carrier | Journal of materials science. Materials in medicine |
| 21433175 | 2011-02-02 | Synthesis and characterization of a block copolymer containing regioregular poly(3-hexylthiophene) and poly(γ-benzyl-L-glutamate) | Macromolecular rapid communications |
| 21107978 | 2011-01-01 | Recent advances in the analysis of the site-specific isotopic fractionation of metabolites such as fatty acids using anisotropic natural-abundance 2H NMR spectroscopy: application to conjugated linolenic methyl esters | Analytical and bioanalytical chemistry |
| 21270961 | 2010-12-08 | Pegylation of poly(γ-benzyl-L-glutamate) nanoparticles is efficient for avoiding mononuclear phagocyte system capture in rats | International journal of nanomedicine |
