N-tert-Butylacrylamide
Product Information
Molecular Formula
C7H13NO
Molecular Weight
127.18
Description
N-tert-Butylacrylamide is a paramount compound that extensively employed in the realm of biomedical research. Garnering recognition for its exceptional attributes, this compound intricately contributes to the synthesis of sundry pharmaceuticals and substances. Its pivotal role in crafting targeted drug delivery systems for combating formidable ailments, including cancer, accentuates its promising prospects in the expansive horizon of biomedicine.
Synonyms
TBA; N-T-BUTYLACRYLAMIDE; N-TERT-BUTYLACRYLAMIDE; N-ACRYLOYL-TERT-BUTYLAMINE; TIMTEC-BB SBB008122; Acrylamide, N-tert-butyl-; n-(1,1-dimethylethyl)-2-propenamid; N-(1,1-dimethylethyl)-2-Propenamide
IUPAC Name
N-tert-butylprop-2-enamide
SMILES
CC(C)(C)NC(=O)C=C
InChI
InChI=1S/C7H13NO/c1-5-6(9)8-7(2,3)4/h5H,1H2,2-4H3,(H,8,9)
InChI Key
XFHJDMUEHUHAJW-UHFFFAOYSA-N
Boiling Point
233.5°C at 760mmHg
Melting Point
128-130°C
Purity
95%
Density
0.876g/cm3
Appearance
white to off-white powder or chunks
Storage
0-6°C
Refractive Index
1.4830 (estimate)
Safety Information
Hazards
H302:
Harmful if swallowed.
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Harmful if swallowed.
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P270:
Do not eat, drink or smoke when using this product.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312+P330:
IF SWALLOWED:
Call a POISON CENTER or doctor/physician if you feel unwell.
Rinse mouth.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Wash thoroughly after handling.
P270:
Do not eat, drink or smoke when using this product.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312+P330:
IF SWALLOWED:
Call a POISON CENTER or doctor/physician if you feel unwell.
Rinse mouth.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Computed Properties
XLogP3
1.1
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
1
Rotatable Bond Count
2
Exact Mass
127.099714038 g/mol
Monoisotopic Mass
127.099714038 g/mol
Topological Polar Surface Area
29.1Ų
Heavy Atom Count
9
Formal Charge
0
Complexity
121
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114149788-A | Slow-release ice and snow melting agent, preparation method thereof and thin-layer cover material containing slow-release ice and snow melting agent | 2021-12-29 |
| CN-113980175-A | Preparation method of modified hydrolyzed polymaleic anhydride | 2021-12-27 |
| CN-114053879-A | Preparation method of potassium ion exchange membrane | 2021-12-16 |
| CN-114058450-A | Stable granular detergent composition and preparation method thereof | 2021-12-03 |
| CN-114149868-A | Tablet detergent composition with hardness and solubility and preparation method thereof | 2021-12-03 |
| CN-113912773-A | Amide polycarboxylic acid water treatment agent, preparation method and application thereof, composite silicon scale-resistant water treatment agent and use method thereof | 2021-11-29 |
| CN-114014994-A | Resistance reducing agent capable of mixing and adjusting viscosity on line, resistance reducing type fracturing fluid and preparation method thereof | 2021-11-19 |
| CN-113897189-A | Jelly glue system suitable for high-temperature high-salinity fracture-cavity oil reservoir profile control and application | 2021-11-18 |
| CN-114044862-A | Preparation method of chitin brush-shaped conductive elastomer material and prepared material | 2021-11-15 |
| JP-2022010263-A | Membrane filtration device | 2021-11-12 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22616950 | 2012-06-11 | Simultaneous enhancement of cell proliferation and thermally induced harvest efficiency based on temperature-responsive cationic copolymer-grafted microcarriers | Biomacromolecules |
| 22525873 | 2012-06-01 | Removal of potentially genotoxic acetamide and arylsulfonate impurities from crude drugs by molecular imprinting | Journal of chromatography. A |
| 22168533 | 2012-01-24 | The effect of nanoparticles on amyloid aggregation depends on the protein stability and intrinsic aggregation rate | Langmuir : the ACS journal of surfaces and colloids |
| 22069302 | 2012-01-01 | Surface chemical immobilization of parylene C with thermosensitive block copolymer brushes based on N-isopropylacrylamide and N-tert-butylacrylamide: synthesis, characterization, and cell adhesion/detachment | Journal of biomedical materials research. Part B, Applied biomaterials |
| 22629123 | 2012-01-01 | The study of release of chlorhexidine from preparations with modified thermosensitive poly-N-isopropylacrylamide microspheres | TheScientificWorldJournal |
| 20387873 | 2010-05-18 | Dynamic viscoelasticity and concentration dependence of micelle-gel transition of styrene and N-tert-butylacrylamide diblock copolymer solutions | Langmuir : the ACS journal of surfaces and colloids |
| 20179998 | 2010-05-01 | Polarity assessment of thermoresponsive poly(NIPAM-co-NtBA) copolymer films using fluorescence methods | Journal of fluorescence |
| 19994868 | 2010-04-20 | Hydrophobic-electrostatic balance driving the LCST offset aggregation-redissolution behavior of N-alkylacrylamide-based ionic terpolymers | Langmuir : the ACS journal of surfaces and colloids |
| 19481217 | 2009-12-11 | Development of a temperature-responsive agarose-based ion-exchange chromatographic resin | Journal of chromatography. A |
| 19580282 | 2009-07-29 | Importance of C-N bond rotation in N-acyl oxazolidinones in their SmI2-promoted coupling to acrylamides | Journal of the American Chemical Society |
