1,4-Dithio-DL-threitol

Catalog Number Size Price Stock Quantity
BPM-296120 10 g $294 In stock
Add to cart

Product Information

Molecular Formula
C4H10O2S2
Molecular Weight
154.25
Description
1,4-Dithio-DL-threitol is a potent reducing agent widely utilized in biochemical applications to stabilize enzymes and proteins. Known for its ability to break disulfide bonds, this compound plays a crucial role in maintaining the integrity of protein structures during various experimental procedures. Its unique configuration allows it to facilitate the reduction of disulfide linkages, thereby enhancing the solubility and functionality of proteins. Ideal for laboratory settings, 1,4-Dithio-DL-threitol is indispensable in research focusing on protein chemistry and enzyme analysis.
Synonyms
DL-1,4-Dithiothreitol; DTT; Cleland's reagent; threo-1,4-Dimercapto-2,3-butanediol; Dithiothreitol; dl-Dithiothreitol; 1,4-Dithiothreitol; D-Dtt; 1,4-Dithio-dl-threitol; DL-Dithiothreitol; threo-1,4-Dimercapto-2,3-butanediol
IUPAC Name
(2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol
Canonical SMILES
C(C(C(CS)O)O)S
InChI
InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1
InChI Key
VHJLVAABSRFDPM-QWWZWVQMSA-N
Boiling Point
125.0-130.0 °C at 2 mmHg
Melting Point
41-44 °C
Flash Point
>230 °F
Purity
≥ 99 % (Assay by titration)
Density
1.040 g/mL at 20 °C
Solubility
Soluble in Water (50 mg/mL, clear, colorless)
Appearance
White crystals or free flowing powder
Application
Used as a reagent in biochemistry to prevent oxidation of thiol groups and to reduce disulfides to dithiols; Has been used as a radioprotectant; Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent.
Storage
Store at 2-8 °C
Refractive Index
1.5200 (estimate)
Stability
May decompose on exposure to moist air or water. Stable under recommended storage conditions
LogP
log Kow = -0.48 (est)
Vapor Pressure
1.28X10-4 mm Hg at 25 °C (est)
Henry's Law Constant
2.9X10-10 atm-cu m/mol at 25 °C (est)
Decomposition
Hazardous decomposition products formed under fire conditions: carbon oxides, Sulfur oxides
Odor
Characteristic

Safety Information

Hazards
H302:
Harmful if swallowed.
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P270:
Do not eat, drink or smoke when using this product.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312+P330:
IF SWALLOWED:
Call a POISON CENTER or doctor/physician if you feel unwell.
Rinse mouth.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Signal Word
Danger

QC Data

Computed Properties

XLogP3
-0.4
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
3
Exact Mass
154.01222190 g/mol
Monoisotopic Mass
154.01222190 g/mol
Topological Polar Surface Area
42.5Ų
Heavy Atom Count
8
Formal Charge
0
Complexity
52
Isotope Atom Count
0
Defined Atom Stereocenter Count
2
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-114134587-A Preparation method of high-performance regenerated pure keratin fiber 2021-12-24
CN-113304708-A Preparation method of glycoprotein microreactor with boron affinity surface imprinting of mesoporous molecular sieve 2021-06-11
CN-113068683-A Cell preservation solution for liquid-based cell examination and preparation method thereof 2021-03-03
WO-2022053525-A1 Array, soaking solutions and method of selecting soaking conditions for small molecules in biological macromolecular crystals 2020-09-08
WO-2022053528-A1 Array, soaking solutions and method of selecting soaking conditions for small molecules in biological macromolecular crystals 2020-09-08
WO-2022044759-A1 Composition containing semiconductor nanoparticles, color filter, and image display device 2020-08-31
WO-2022044761-A1 Composition containing semiconductor nanoparticles, color filter, and image display device 2020-08-31
JP-2022024764-A Antioxidants and their manufacturing methods, pharmaceutical compositions and their manufacturing methods, foods, and cosmetics 2020-07-28
WO-2022020288-A1 Antibody-conjugated chemical inducers of degradation of brm and methods thereof 2020-07-21
WO-2022006231-A1 Dpagt1 inhibitors of capuramycin analogues and their antimigratory activities of solid tumors 2020-06-30

Literatures

PMID Publication Date Title Journal
34244458 2021-10-01 Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules RNA (New York, N.Y.)
31339623 2019-10-01 Unfolded protein response regulates P53 expression in the pulmonary endothelium Journal of biochemical and molecular toxicology
28837777 2017-09-18 Arsenite Binds to the Zinc Finger Motif of TIP60 Histone Acetyltransferase and Induces Its Degradation via the 26S Proteasome Chemical research in toxicology
25446071 2015-01-02 Impact of cadmium, cobalt and nickel on sequence-specific DNA binding of p63 and p73 in vitro and in cells Biochemical and biophysical research communications
23933410 2013-10-25 In vitro glutathione peroxidase mimicry of ebselen is linked to its oxidation of critical thiols on key cerebral suphydryl proteins - A novel component of its GPx-mimic antioxidant mechanism emerging from its thiol-modulated toxicology and pharmacology Chemico-biological interactions
23618698 2013-08-01 Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay Biochimica et biophysica acta
23710884 2013-08-01 Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells Journal of thrombosis and haemostasis : JTH
23261715 2013-02-25 Modulation of activity and inhibitor sensitivity of rabbit aldose reductase-like protein (AKR1B19) by oxidized glutathione and SH-reagents Chemico-biological interactions
22867017 2013-02-01 Disulfide bond as a switch for copper-zinc superoxide dismutase activity in asthma Antioxidants & redox signaling
22884002 2013-01-15 Sensitive and antifouling impedimetric aptasensor for the determination of thrombin in undiluted serum sample Biosensors & bioelectronics
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Related Products

Online Inquiry
  • Verification code
USA
  • International:
  • US & Canada (Toll free):
  • Email:
  • Fax:
UK
Germany
Copyright © 2026 BOC Sciences. All rights reserved.
Top
Inquiry Basket