1,4-Dithio-DL-threitol
| Catalog Number | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| BPM-296120 | 10 g | $294 | In stock |
Product Information
Molecular Formula
C4H10O2S2
Molecular Weight
154.25
Description
1,4-Dithio-DL-threitol is a potent reducing agent widely utilized in biochemical applications to stabilize enzymes and proteins. Known for its ability to break disulfide bonds, this compound plays a crucial role in maintaining the integrity of protein structures during various experimental procedures. Its unique configuration allows it to facilitate the reduction of disulfide linkages, thereby enhancing the solubility and functionality of proteins. Ideal for laboratory settings, 1,4-Dithio-DL-threitol is indispensable in research focusing on protein chemistry and enzyme analysis.
Synonyms
DL-1,4-Dithiothreitol; DTT; Cleland's reagent; threo-1,4-Dimercapto-2,3-butanediol; Dithiothreitol; dl-Dithiothreitol; 1,4-Dithiothreitol; D-Dtt; 1,4-Dithio-dl-threitol; DL-Dithiothreitol; threo-1,4-Dimercapto-2,3-butanediol
IUPAC Name
(2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol
SMILES
C(C(C(CS)O)O)S
InChI
InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1
InChI Key
VHJLVAABSRFDPM-QWWZWVQMSA-N
Boiling Point
125.0-130.0 °C at 2 mmHg
Melting Point
41-44 °C
Flash Point
>230 °F
Purity
≥ 99 % (Assay by titration)
Density
1.040 g/mL at 20 °C
Solubility
Soluble in Water (50 mg/mL, clear, colorless)
Appearance
White crystals or free flowing powder
Application
Used as a reagent in biochemistry to prevent oxidation of thiol groups and to reduce disulfides to dithiols; Has been used as a radioprotectant; Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent.
Storage
Store at 2-8 °C
Refractive Index
1.5200 (estimate)
Stability
May decompose on exposure to moist air or water. Stable under recommended storage conditions
LogP
log Kow = -0.48 (est)
Vapor Pressure
1.28X10-4 mm Hg at 25 °C (est)
Henry's Law Constant
2.9X10-10 atm-cu m/mol at 25 °C (est)
Decomposition
Hazardous decomposition products formed under fire conditions: carbon oxides, Sulfur oxides
Odor
Characteristic
Safety Information
Hazards
H302:
Harmful if swallowed.
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Harmful if swallowed.
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P270:
Do not eat, drink or smoke when using this product.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312+P330:
IF SWALLOWED:
Call a POISON CENTER or doctor/physician if you feel unwell.
Rinse mouth.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Wash thoroughly after handling.
P270:
Do not eat, drink or smoke when using this product.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312+P330:
IF SWALLOWED:
Call a POISON CENTER or doctor/physician if you feel unwell.
Rinse mouth.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Signal Word
Danger
QC Data
Computed Properties
XLogP3
-0.4
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
3
Exact Mass
154.01222190 g/mol
Monoisotopic Mass
154.01222190 g/mol
Topological Polar Surface Area
42.5Ų
Heavy Atom Count
8
Formal Charge
0
Complexity
52
Isotope Atom Count
0
Defined Atom Stereocenter Count
2
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114134587-A | Preparation method of high-performance regenerated pure keratin fiber | 2021-12-24 |
| CN-113304708-A | Preparation method of glycoprotein microreactor with boron affinity surface imprinting of mesoporous molecular sieve | 2021-06-11 |
| CN-113068683-A | Cell preservation solution for liquid-based cell examination and preparation method thereof | 2021-03-03 |
| WO-2022053525-A1 | Array, soaking solutions and method of selecting soaking conditions for small molecules in biological macromolecular crystals | 2020-09-08 |
| WO-2022053528-A1 | Array, soaking solutions and method of selecting soaking conditions for small molecules in biological macromolecular crystals | 2020-09-08 |
| WO-2022044759-A1 | Composition containing semiconductor nanoparticles, color filter, and image display device | 2020-08-31 |
| WO-2022044761-A1 | Composition containing semiconductor nanoparticles, color filter, and image display device | 2020-08-31 |
| JP-2022024764-A | Antioxidants and their manufacturing methods, pharmaceutical compositions and their manufacturing methods, foods, and cosmetics | 2020-07-28 |
| WO-2022020288-A1 | Antibody-conjugated chemical inducers of degradation of brm and methods thereof | 2020-07-21 |
| WO-2022006231-A1 | Dpagt1 inhibitors of capuramycin analogues and their antimigratory activities of solid tumors | 2020-06-30 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 34244458 | 2021-10-01 | Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules | RNA (New York, N.Y.) |
| 31339623 | 2019-10-01 | Unfolded protein response regulates P53 expression in the pulmonary endothelium | Journal of biochemical and molecular toxicology |
| 28837777 | 2017-09-18 | Arsenite Binds to the Zinc Finger Motif of TIP60 Histone Acetyltransferase and Induces Its Degradation via the 26S Proteasome | Chemical research in toxicology |
| 25446071 | 2015-01-02 | Impact of cadmium, cobalt and nickel on sequence-specific DNA binding of p63 and p73 in vitro and in cells | Biochemical and biophysical research communications |
| 23933410 | 2013-10-25 | In vitro glutathione peroxidase mimicry of ebselen is linked to its oxidation of critical thiols on key cerebral suphydryl proteins - A novel component of its GPx-mimic antioxidant mechanism emerging from its thiol-modulated toxicology and pharmacology | Chemico-biological interactions |
| 23618698 | 2013-08-01 | Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay | Biochimica et biophysica acta |
| 23710884 | 2013-08-01 | Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells | Journal of thrombosis and haemostasis : JTH |
| 23261715 | 2013-02-25 | Modulation of activity and inhibitor sensitivity of rabbit aldose reductase-like protein (AKR1B19) by oxidized glutathione and SH-reagents | Chemico-biological interactions |
| 22867017 | 2013-02-01 | Disulfide bond as a switch for copper-zinc superoxide dismutase activity in asthma | Antioxidants & redox signaling |
| 22884002 | 2013-01-15 | Sensitive and antifouling impedimetric aptasensor for the determination of thrombin in undiluted serum sample | Biosensors & bioelectronics |
