poly(vinylpyrrolidone)

Product Information

Molecular Formula:
(C6H9NO)n
Description
Crospovidone is used as a drug excipient in drug formulations.
Synonyms
PVP; K-30; PVP-K; PVP-K30; PVP-K17; PVP-K25; PVP-K90
IUPAC Name
1-ethenylpyrrolidin-2-one
Canonical SMILES
C=CN1CCCC1=O
InChI
InChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2
InChI Key
WHNWPMSKXPGLAX-UHFFFAOYSA-N
Boiling Point
217.6°C at 760 mmHg
Melting Point
130°C
Flash Point
93.9°C
Density
1.144g/cm3
Solubility
Soluble in chloroform (slightly), methanol (slightly).
Appearance
White to yellowish-white powder
Application
Used as a monomer in the production of polyvinyl pyrrolidone; also used in the production of other polymers and organic chemicals.
Storage
Room Temperature
Tg
120°C
Stability
Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.
LogP
0.6902
Vapor Pressure
0.1 [mmHg]
Henry's Law Constant
5.5X10-8 atm-cu m/mol @ 25 °C /Estimated/
Decomposition
When heated to decomposition it emits toxic fumes of nitroxides. /Poly(1-vinyl-2-pyrrolidinone) homopolymer and Hueper's polymer 1-7/
Odor
ODORLESS

Safety Information

Hazards
Harmless-use normal precautions
Handling
Exercise normal care
Molecular WeightViscosityDescription
Mw 10000 1% AQ 1.21-1.28 cps Water-soluble polymer used as a thickener, protective colloid. Tg~155℃ Polydispersity ~3.6
Mw 2500 5% AQ 1.25-1.37 cps Water-soluble polymer used as a thickener, protective colloid. Tg~90℃. Polydispersity ~1.9
Mw 40000 1% AQ 3.65 cps Pharmaceutical grade. Tg~168℃
Mw 1000000 1% AQ 4.90 cp Water-soluble polymer used as a thickener, protective colloid. Tg>175℃ Polydispersity ~2.00

Computed Properties

XLogP3
0.4
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
1
Rotatable Bond Count
1
Exact Mass
111.068413911 g/mol
Monoisotopic Mass
111.068413911 g/mol
Topological Polar Surface Area
20.3Ų
Heavy Atom Count
8
Formal Charge
0
Complexity
120
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
EP-3818972-A2 Piroctone olamine granules for use in cosmetic compositions 2021-01-29
US-2021007978-A1 Fixed Dose Oral Testosterone Undecanoate Compositions and Use Thereof 2020-09-25
US-11033516-B1 Combination therapies with disulfiram 2020-09-18
US-11028300-B1 Environmentally friendly refrigerant compositions 2020-09-16
US-10858566-B2 Drilling fluid with improved fluid loss and viscosifying properties 2020-04-14
US-2020255716-A1 Drilling fluid with improved fluid loss and viscosifying properties 2020-04-14
US-11045434-B1 Niclosamide formulations for treating disease 2020-04-01
US-11007134-B1 Ceramide containing capsules, ceramide compositions, and cosmetic compositions thereof 2020-03-31
EP-3799848-A1 Absorbent articles and methods of making 2020-03-19
EP-3677244-A2 Compositions comprising multilamellar vesicles 2020-02-04

Literatures

PMID Publication Date Title Journal
34595563 2021-12-01 Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat Archives of toxicology
22800730 2012-12-01 Synthesis of gum kondagogu-g-poly(N-vinyl-2-pyrrolidone) and its evaluation as a mucoadhesive polymer International journal of biological macromolecules
22590998 2012-11-01 Does vaginal preparation with povidone-iodine prior to caesarean delivery reduce the risk of endometritis? A randomized controlled trial The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
23079318 2012-11-01 Bilateral Fusarium oxysporum keratitis after laser in situ keratomileusis Journal of cataract and refractive surgery
23090520 2012-11-01 Chlorhexidine-alcohol compared with povidone-iodine for surgical-site antisepsis in cesarean deliveries Obstetrics and gynecology
22705046 2012-10-01 Photo-crosslinked networks prepared from fumaric acid monoethyl ester-functionalized poly(D,L-lactic acid) oligomers and N-vinyl-2-pyrrolidone for the controlled and sustained release of proteins Acta biomaterialia
22797354 2012-10-01 A multicentre analysis of catheter-related infection based on a hierarchical model Intensive care medicine
22909110 2012-10-01 Low-cost periodontal therapy Periodontology 2000
22964685 2012-10-01 Evidence-based protocol for infection control in immediate implant-based breast reconstruction Annals of plastic surgery
22891651 2012-09-11 In situ monitoring of Pt nanoparticle formation in ethylene glycol solution by SAXS-influence of the NaOH to Pt ratio Langmuir : the ACS journal of surfaces and colloids
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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