Dithioerythritol

Product Information

Molecular Formula:
C4H10O2S2
Molecular Weight:
154.25
Description
Reagent for the reduction of disulfide group. Prevents oxidation of sulfhydryl-containing proteins during SDS-polyacrylamide gel electrophoresis. Cleavage of disulfide bonds in proteins
Synonyms
1,4-Dithioerythritol; (2R,3S)-1,4-bis(sulfanyl)butane-2,3-diol;
IUPAC Name
(2R,3S)-1,4-bis(sulfanyl)butane-2,3-diol
Canonical SMILES
C(C(C(CS)O)O)S
InChI
1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+
InChI Key
VHJLVAABSRFDPM-ZXZARUISSA-N
Boiling Point
364.5°C at 760 mmHg
Melting Point
82-88 °C
Purity
≥98%
Density
1.302 g/cm3
Solubility
Soluble in DMSO
Appearance
White solid
Application
White crystals
Shelf Life
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Storage
Store at -20 °C
Refractive Index
1.5200 (estimate)

Safety Information

Hazards
H302+H312+H332:
Harmful if swallowed.
Harmful in contact with skin.
Harmful if inhaled.
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P261:
Avoid breathing dust, fumes, gas, mist, vapours, spray. [As modified by IV ATP].
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352+P312:
IF ON SKIN:
Wash with plenty of soap and water.
Call a POISON CENTER or doctor/physician if you feel unwell.
P304+P340+P312:
IF INHALED:
Remove person to fresh air and keep comfortable for breathing.
Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313:
If eye irritation persists:
Get medical advice/attention.

Computed Properties

XLogP3
-0.4
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
3
Exact Mass
154.01222190 g/mol
Monoisotopic Mass
154.01222190 g/mol
Topological Polar Surface Area
42.5Ų
Heavy Atom Count
8
Formal Charge
0
Complexity
52
Isotope Atom Count
0
Defined Atom Stereocenter Count
2
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-114113399-A Ceftiofur detection method and application thereof 2021-12-02
CN-113777312-A Preparation method of hepatitis B antibody fragment, kit and application 2021-09-03
CN-113683676-A Environment-friendly reversible protein denaturation process 2021-08-27
CN-113528441-A Rapid and efficient clinical-grade pigment epithelial cell induction method, kit and application 2021-08-05
CN-113564122-A Method for differentiating human induced pluripotent stem cells into oligodendrocytes, kit and application 2021-08-05
CN-113209364-A Polymer hydrogel with tissue light healing function and preparation and application thereof 2021-05-14
CN-113209364-B Polymer hydrogel with tissue light healing function and preparation and application thereof 2021-05-14
CN-113278598-A Biological enzyme system for preparing drug metabolites and application thereof 2021-04-25
JP-2021080483-A Complex 2021-03-04
CN-113004377-A Renaturation method of new coronavirus recombinant protein inclusion body 2021-02-07

Literatures

PMID Publication Date Title Journal
25849418 2015-05-18 Mitochondrial carnitine/acylcarnitine transporter, a novel target of mercury toxicity Chemical research in toxicology
25490951 2015-03-01 Functional and molecular effects of mercury compounds on the human OCTN1 cation transporter: C50 and C136 are the targets for potent inhibition Toxicological sciences : an official journal of the Society of Toxicology
23402788 2013-04-25 Inhibition of mitochondrial carnitine/acylcarnitine transporter by H(2)O(2): molecular mechanism and possible implication in pathophysiology Chemico-biological interactions
22900493 2013-02-01 Inhibition of the OCTN2 carnitine transporter by HgCl2 and methylmercury in the proteoliposome experimental model: insights in the mechanism of toxicity Toxicology mechanisms and methods
23010140 2012-11-15 Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity Toxicology and applied pharmacology
23062438 2012-10-31 Determination of biothiols by a novel on-line HPLC-DTNB assay with post-column detection Analytica chimica acta
22845804 2012-08-07 Shift in the equilibrium between on and off states of the allosteric switch in Ras-GppNHp affected by small molecules and bulk solvent composition Biochemistry
21729133 2012-05-01 Effects of curcumin and dithioerythritol on frozen-thawed bovine semen Andrologia
22378944 2012-05-01 Two carbon fluxes to reserve starch in potato (Solanum tuberosum L.) tuber cells are closely interconnected but differently modulated by temperature Journal of experimental botany
22220568 2012-04-01 Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase The Biochemical journal
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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