Lansoprazole EP Impurity E

Product Information

Molecular Formula:
C7H6N2S
Molecular Weight:
150.20
Description
An impurity of Rabeprazole. Rabeprazole is a proton pump inhibitor as an antiulcer drug.
Synonyms
1,3-Dihydro-2H-benzimidazole-2-thione, 2-Benzimidazolethiol; 2-Mercaptobenzimidazole; Lansoprazole EP Impurity E; Rabeprazole Related Compound C; Rabeprazole sodium EP Impurity F
IUPAC Name
1,3-dihydrobenzimidazole-2-thione
Canonical SMILES
C1=CC=C2C(=C1)NC(=S)N2
InChI
InChI=1S/C7H6N2S/c10-7-8-5-3-1-2-4-6(5)9-7/h1-4H,(H2,8,9,10)
InChI Key
YHMYGUUIMTVXNW-UHFFFAOYSA-N
Boiling Point
451 °C
Melting Point
>285°C
Purity
> 95%
Density
1.42
Solubility
>22.5 [ug/mL] (The mean of the results at pH 7.4)
Appearance
White to Off-White Solid
Application
Purine synthesis antimetabolite. Used as an intermediate, in rubber product manufacturing, and electroplating,.
Vapor Pressure
30.2 mmHg at 142 °F

Safety Information

Hazards
H301:
Toxic if swallowed.
H317:
May cause an allergic skin reaction.
H319:
Causes serious eye irritation.
H373:
May cause damage to organs through prolonged or repeated exposure.
H412:
Harmful to aquatic life with long-lasting effects.
Precautionary Statement
P260:
Do not breathe dust, fumes, gas, mist, vapours, spray.
P264:
Wash thoroughly after handling.
P273:
Avoid release to the environment.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310+P330:
IF SWALLOWED:
Immediately call a POISON CENTER or doctor/physician.
Rinse mouth.
P314:
Get medical advice/attention if you feel unwell.

Computed Properties

XLogP3
1.7
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
1
Rotatable Bond Count
0
Exact Mass
150.02516937 g/mol
Monoisotopic Mass
150.02516937 g/mol
Topological Polar Surface Area
56.2Ų
Heavy Atom Count
10
Formal Charge
0
Complexity
142
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-114149626-A Flame-retardant light rubber-plastic foamed product and manufacturing method thereof 2022-01-04
CN-114134544-A Alkaline copper plating additive for electronic engraving printing gravure 2021-12-31
CN-114149640-A Oil-resistant ethylene propylene diene monomer hose and preparation method thereof 2021-12-30
CN-113980357-A Functionalized graphene, preparation method thereof and application of functionalized graphene in rubber base plate 2021-12-27
CN-114163419-A Preparation method of lansoprazole 2021-12-24
JP-2022037181-A A method for producing a chemically amplified photosensitive composition, a photosensitive dry film, and a method for producing a patterned resist film. 2021-12-22
CN-113999520-A Transparent rubber airtight material and preparation method and application thereof 2021-12-21
CN-114032588-A Pre-plating solution and pre-plating process for cyanide-free alkaline copper plating, electroplating solution and electroplating process 2021-12-16
CN-114058008-A Process for preparing semi-aromatic polyamides end-capped with monocarboxylic acids, semi-aromatic polyamides and molding compositions 2021-12-13
CN-114058009-A Process for preparing semi-aromatic polyamides with reduced loss of diamine monomer, semi-aromatic polyamides and molding compositions 2021-12-13

Literatures

PMID Publication Date Title Journal
22805508 2012-07-17 A facile and efficient procedure for the synthesis of new benzimidazole-2-thione derivatives Molecules (Basel, Switzerland)
22349321 2012-07-01 Thyreostatic drugs, stability in bovine and porcine urine Analytical and bioanalytical chemistry
22473800 2012-05-14 Selective and sensitive recognition of Cu2+ in an aqueous medium: a surface-enhanced Raman scattering (SERS)-based analysis with a low-cost Raman reporter Chemistry (Weinheim an der Bergstrasse, Germany)
22590282 2012-05-01 (Z)-2-(4-Chloro-benzyl-idene)benzo[d]thia-zolo[3,2-a]imidazol-3(2H)-one Acta crystallographica. Section E, Structure reports online
22302165 2012-04-01 Electrochemically synthesized polymers in molecular imprinting for chemical sensing Analytical and bioanalytical chemistry
22347012 2012-02-01 3-Fluoro-12H-benzimidazo[2,1-b][1,3]benzothia-zin-12-one Acta crystallographica. Section E, Structure reports online
22223274 2012-01-01 The conformations of two copper(I) complexes of 1H-benzimidazole-2(3H)-thione and thiosaccharinate Acta crystallographica. Section C, Crystal structure communications
22574507 2012-01-01 Anticonvulsant evaluation of some newer benzimidazole derivatives: design and synthesis Acta poloniae pharmaceutica
22199976 2011-12-01 2-Methyl-12H-benzimidazo[2,1-b][1,3]benzothia-zin-12-one Acta crystallographica. Section E, Structure reports online
22064924 2011-10-01 2-(1H-1,3-Benzodiazol-2-ylsulfan-yl)-1-(4-chloro-phen-yl)ethanone Acta crystallographica. Section E, Structure reports online
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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