Poly(3-hydroxybutyric acid)

Product Information

Molecular Formula:
C12H18O6X2
Molecular Weight:
258.27
Description
3-hydroxybutyric acid is a straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics. It has a role as a human metabolite. It is a 3-hydroxy monocarboxylic acid, a hydroxybutyric acid and an (omega-1)-hydroxy fatty acid. It is functionally related to a butyric acid. It is a conjugate acid of a 3-hydroxybutyrate.
Synonyms
POLY(3-HYDROXYBUTYRATE); POLY(3-HYDROXYBUTYRATE) OLIGOMER; POLY(3-HYDROXYBUTYRIC ACID); POLY[(-)3-HYDROXYBUTYRIC ACID]; poly-beta-hydroxybutyrate; POLY(3-HYDROXYBUTYRIC ACID), NATURAL ORI GIN; Poly(3-hydroxyvalericacid); 3-hydroxybutyric acid homopolymer
IUPAC Name
3-hydroxybutanoic acid
Canonical SMILES
CC(CC(=O)O)O
InChI
InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)
InChI Key
WHBMMWSBFZVSSR-UHFFFAOYSA-N
Purity
0.995
Density
1.195 g/cm3
Application
Ketone produced in the liver.
Storage
Store at room temperature
Tg
15°

Safety Information

Hazards
Harmless-use normal precautions
Handling
Exercise normal care
Molecular WeightDescription
Mw ~500,000 Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance.
Mw ~2000 Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance.
Mw ~5000 Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance.
Mw ~3000 Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance.
Mw ~500 Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance.
Mw ~1000 Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance.
Mw ~10,000 Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance.

Computed Properties

XLogP3
-0.5
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
2
Exact Mass
104.047344113 g/mol
Monoisotopic Mass
104.047344113 g/mol
Topological Polar Surface Area
57.5Ų
Heavy Atom Count
7
Formal Charge
0
Complexity
69.3
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-114134096-A 3-hydroxybutyrate, 4-hydroxybutyrate and 3-hydroxyvalerate terpolymer P (3HB-4HB-3HV) and microbial production thereof 2022-02-07
CN-114134095-A Method for producing L-lysine and/or 1, 5-pentanediamine by using halophilic bacteria 2022-01-28
CN-114166977-A System for predicting blood glucose value of pregnant individual 2022-01-24
CN-114167066-A Application of biomarker in preparation of gestational diabetes diagnosis reagent 2022-01-24
CN-114031760-A High-barrier-property high-strength PBAT-PGA (poly (butylene adipate-co-terephthalate) -poly (propylene glycol)) block copolymer biodegradable polyester and preparation method thereof 2022-01-07
CN-113999869-A Promoter with expression intensity regulated by synthesis of bacterial intracellular Polyhydroxyalkanoate (PHA) and application thereof 2021-12-31
JP-2022037181-A A method for producing a chemically amplified photosensitive composition, a photosensitive dry film, and a method for producing a patterned resist film. 2021-12-22
CN-113929762-A 3-hydroxybutyrylated and/or 3-hydroxypentylglycolylated modified insulin and application thereof 2021-12-16
CN-114058221-A Water-based high-wear-resistance high-hardness high-scratch-resistance core-shell structure wax emulsion and preparation method thereof 2021-12-16
CN-114149604-A Near-infrared light response type slow-release composite packaging film and preparation method and application thereof 2021-12-15

Literatures

PMID Publication Date Title Journal
32634519 2020-09-01 Comparative proteomic analysis of SLC13A5 knockdown reveals elevated ketogenesis and enhanced cellular toxic response to chemotherapeutic agents in HepG2 cells Toxicology and applied pharmacology
31332890 2019-09-01 β-Hydroxybutyrate exacerbates lipopolysaccharide/ d-galactosamine-induced inflammatory response and hepatocyte apoptosis in mice Journal of biochemical and molecular toxicology
29968805 2018-07-03 Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics Scientific reports
29738703 2018-06-01 High fat diet induced obesity is mitigated in Cyp3a-null female mice Chemico-biological interactions
27816970 2017-04-04 HMGCS2 enhances invasion and metastasis via direct interaction with PPARα to activate Src signaling in colorectal cancer and oral cancer Oncotarget
27481192 2016-09-25 1'-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells Chemico-biological interactions
25943029 2015-08-01 Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway Molecular nutrition & food research
25686106 2015-03-01 The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease Nature medicine
25440059 2014-11-04 A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome Cell metabolism
22687249 2012-11-30 Artificial microRNA-mediated knockdown of pyruvate formate lyase (PFL1) provides evidence for an active 3-hydroxybutyrate production pathway in the green alga Chlamydomonas reinhardtii Journal of biotechnology
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Online Inquiry
  • Verification code
USA
  • International:
  • US & Canada (Toll free):
  • Email:
  • Fax:
UK
  • Email:
Copyright © 2024 BOC Sciences. All rights reserved.
Inquiry Basket