Poly(ethylene glycol) diglycidyl ether

Product Information

Molecular Formula:
C3H5O2-(C2H4O)n-C3H5O
Molecular Weight:
174.19
Description
Poly(ethylene glycol) diglycidyl ether is an incredibly versatile compound extensively utilized in the biomedical industry. It acts as a pivotal crosslinking agent for synthesizing biofunctional materials and drug delivery systems. With its remarkable reactivity, it empowers the fabrication of hydrogels and coatings, ultimately resulting in the precise and controlled release of medications for targeted therapy. Its wide-ranging application encompasses the effective treatment of several ailments, ranging from cancer and inflammation to cardiovascular disorders, showcasing its immense potential in advancing the field of medicine.
Synonyms
Diepoxy PEG, PEG diglycidyl ether, Polyoxyethylene bis(glycidyl ether)
IUPAC Name
2-[2-(oxiran-2-ylmethoxy)ethoxymethyl]oxirane
Canonical SMILES
C1C(O1)COCCOCC2CO2
InChI
InChI=1S/C8H14O4/c1(9-3-7-5-11-7)2-10-4-8-6-12-8/h7-8H,1-6H2
InChI Key
AOBIOSPNXBMOAT-UHFFFAOYSA-N
Purity
98%
Storage
Store at 4°C.

Safety Information

Hazards
Irritant
Handling
Gloves & chemical goggles
Molecular WeightDescription
Average Mn ~600 Poly(ethylene glycol) diglycidyl ether (PEGDGE) shows highly solubility in water. Hence, it easily undergoes hydrolysis followed by ring cleavage reaction in aqueous solution, yielding hydroxyl group. PEGDGE combines with proteins covalently or non-covalently. PEGDGE is widely used in chemical industries for cross linking and surface modifier
Average Mn ~200 The high solubility of PEGDGE has been successfully employed to immobilize glucose oxidase, d-amino acid oxidase and glutamate oxidase. It may be used as a component for the development of microelectrode biosensors to detect hydrogen peroxide and nitric oxid
Average Mn ~400 Poly(ethylene glycol) diglycidyl ether (PEGDGE) shows highly solubility in water. Hence, it easily undergoes hydrolysis followed by ring cleavage reaction in aqueous solution, yielding hydroxyl group. PEGDGE combines with proteins covalently or non-covalently. PEGDGE is widely used in chemical industries for cross linking and surface modifier
Average Mn ~1000 Tm is 4-8 ℃.The high solubility of PEGDGE has been successfully employed to immobilize glucose oxidase, d-amino acid oxidase and glutamate oxidase. It may be used as a component for the development of microelectrode biosensors to detect hydrogen peroxide and nitric oxid

Computed Properties

XLogP3
-0.7
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
7
Exact Mass
174.08920892 g/mol
Monoisotopic Mass
174.08920892 g/mol
Topological Polar Surface Area
43.5Ų
Heavy Atom Count
12
Formal Charge
0
Complexity
123
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
2
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
EP-3677244-A2 Compositions comprising multilamellar vesicles 2020-02-04
EP-3842469-A1 Material for forming organic film, method for forming organic film, patterning process, and compound 2019-12-26
US-2021190718-A1 Analyte Sensors and Sensing Methods Featuring Low-Potential Detection 2019-12-23
US-2021190719-A1 Analyte sensors and sensing methods featuring low-potential detection 2019-12-23
WO-2021124125-A1 Process for the preparation of a bonding resin 2019-12-20
WO-2021124129-A1 Process for preparing a bonding resin 2019-12-20
WO-2021124668-A1 Adhesive composition 2019-12-20
WO-2021124726-A1 Fiber-reinforced resin molding material, fiber-reinforced resin molded article, and method for manufacturing fiber-reinforced resin molded article 2019-12-20
WO-2021124854-A1 Adhesive sheet 2019-12-20
WO-2021124855-A1 Adhesive sheet 2019-12-20

Literatures

PMID Publication Date Title Journal
21556975 2011-06-01 Extruded collagen fibres for tissue engineering applications: effect of crosslinking method on mechanical and biological properties Journal of materials science. Materials in medicine
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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