Polyoxyethylene stearate

Product Information

Molecular Formula:
HO(CH2CH2O)nOCC17H35
Description
Polyoxyethylene stearate is commonly used as an emulsifier and a surfactant in pharmaceutical formulations.
Synonyms
2-Hydroxyethyl stearate; Ethylene glycol monostearate; Glycol stearate; 2-Hydroxyethyl octadecanoate; Cremophor A; Glycol monostearate; Monthybase; Parastarin; Monthyle; Sedetol; Ivorit; Prodhybase ethyl; Prodhybas N; Cerasynt M; Clearate G; Cerasynt MN; Cithrol PS; Clindrol SEG; OCTADECANOIC ACID, 2-HYDROXYETHYL ESTER; Lipo EGMS; Cithrol 10MS; Lactine; Cerasynt 660; Myrj; Tego-stearate; Akyporox S 100; Prodhybase P; PEG stearate; Emerest 2350; Emerest 2640; Empilan 2848; Lamacit CA; Soromin-SG
IUPAC Name
2-hydroxyethyl octadecanoate
Canonical SMILES
CCCCCCCCCCCCCCCCCC(=O)OCCO
InChI
InChI=1S/C20H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)23-19-18-21/h21H,2-19H2,1H3
InChI Key
RFVNOJDQRGSOEL-UHFFFAOYSA-N
Boiling Point
438.00 to 439.00 °C at 760.00 mm Hg (est)
Melting Point
47°C
Flash Point
39°C
Density
0.913 g/cm³
Solubility
POLYETHYLENE GLYCOL ESTERS AND ETHERS INCR THE WATER SOLUBILITY OF TYROTHRICIN
Appearance
Light amber semisolid
Application
Used as a surfactant, emulsifier (cosmetics, pharmaceuticals, textile finishes, defoamers, and baked goods), dye assistant, lubricant, and antistatic agent; Also used in dentifrice compositions and to make creams, lotions, ointments, and pharmaceutical preparations.
Storage
Keep tightly closed in a cool place in a tightly closed container.
Stability
Stable.
LogP
7.629 (est)
Odor
FAINT FATTY ODOR

Safety Information

Handling
Dust mask type N95 (US), Eyeshields, Gloves
Molecular WeightDescription
n=approx. 55 White to Almost white powder to crystal. Tm is 53℃
n=approx. 10 White to Almost white powder to lump
n=approx. 45 White to Almost white powder to crystal. Tm is 52℃
n=approx. 4 White to Almost white powder to lump
n=approx. 2 White to Almost white wax
n=approx. 25 White to Almost white powder to lump. Tm is 39℃
n=approx. 40 White to Almost white wax. Tm is 47℃.

Computed Properties

XLogP3
7.8
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
19
Exact Mass
328.29774513 g/mol
Monoisotopic Mass
328.29774513 g/mol
Topological Polar Surface Area
46.5Ų
Heavy Atom Count
23
Formal Charge
0
Complexity
241
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
EP-3818972-A2 Piroctone olamine granules for use in cosmetic compositions 2021-01-29
US-11033516-B1 Combination therapies with disulfiram 2020-09-18
WO-2021073174-A1 Multi-walled carbon nanotube composite form-stable phase change material, and preparation method and use therefor 2020-05-29
WO-2021036533-A1 Epoxy resin composite form-stable phase change material, preparation method therefor, and application 2020-04-10
US-11007134-B1 Ceramide containing capsules, ceramide compositions, and cosmetic compositions thereof 2020-03-31
US-10980756-B1 Methods of treatment 2020-03-16
EP-3677244-A2 Compositions comprising multilamellar vesicles 2020-02-04
US-2021186858-A1 Low irritation skincare cosmetic composition 2019-12-24
US-2021186848-A1 Water resistance sunscreen compositions 2019-12-20
US-2021189292-A1 Surfactants for cleaning products 2019-12-20

Literatures

PMID Publication Date Title Journal
22209995 2012-02-27 Controlling lipolysis through steric surfactants: new insights on the controlled degradation of submicron emulsions after oral and intravenous administration International journal of pharmaceutics
21939700 2012-02-10 Thermally-triggered 'off-on-off' response of gadolinium-hydrogel-lipid hybrid nanoparticles defines a customizable temperature window for non-invasive magnetic resonance imaging thermometry Journal of controlled release : official journal of the Controlled Release Society
22119655 2012-01-23 Octreotide-modified and pH-triggering polymeric micelles loaded with doxorubicin for tumor targeting delivery European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
21770405 2011-10-03 Effect of octreotide-polyethylene glycol(100) monostearate modification on the pharmacokinetics and cellular uptake of nanostructured lipid carrier loaded with hydroxycamptothecine Molecular pharmaceutics
21558002 2011-09-01 Lipid nanocapsules for dermal application: a comparative study of lipid-based versus polymer-based nanocarriers European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
20740670 2011-02-01 Oral apomorphine delivery from solid lipid nanoparticles with different monostearate emulsifiers: pharmacokinetic and behavioral evaluations Journal of pharmaceutical sciences
20934499 2010-12-15 Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for cyclosporine A: Improving in vivo ocular distribution International journal of pharmaceutics
20149853 2010-05-10 In vitro drug release mechanism from lipid nanocapsules (LNC) International journal of pharmaceutics
19393270 2009-08-04 Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery Journal of controlled release : official journal of the Controlled Release Society
18583110 2008-10-01 Controlled complexation of plasmid DNA with cationic polymers: effect of surfactant on the complexation and stability of the complexes Colloids and surfaces. B, Biointerfaces
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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