Voriconazole EP Impurity E
Product Information
Molecular Formula
C10H16O4S
Molecular Weight
232.30
Description
Voriconazole EP Impurity E is an impurity of Voriconazole, which is an antifungal medication used to treat a number of fungal infections.
Synonyms
[(1RS,4SR)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; (±)-10-Camphorsulfonic acid; Voriconazole Impurity E; Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-; (±)-7,7-Dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-methanesulfonic Acid; (±)-2-Oxo-10-bornanesulfonic Acid; (RS)-10-Camphorsulfonic Acid; (±)-Camphor-10-sulfonic Acid; 2-Oxo-10-bornanesulfonic Acid; DL-Camphorsulfonic Acid; USP Voriconazole Related Compound F; Voriconazole USP Related Compound F; Voriconazole Related Compound F; 10-Bornanesulfonic acid, 2-oxo-, (±)-; 7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid; Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (±)-; (7,7-Dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic acid; (7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid; (7,7-Dimethyl-3-oxoniumylidene-4-bicyclo[2.2.1]heptanyl)methanesulfonate; DL-10-Camphorsulfonic acid
IUPAC Name
(7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl)methanesulfonic acid
SMILES
CC1(C2CCC1(C(=O)C2)CS(=O)(=O)O)C
InChI
InChI=1S/C10H16O4S/c1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h7H,3-6H2,1-2H3,(H,12,13,14)
InChI Key
MIOPJNTWMNEORI-UHFFFAOYSA-N
Melting Point
153°C
Flash Point
Not applicable
Purity
98%
Density
1.331±0.06 g/cm3
Solubility
Soluble in Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Ethyl Acetate (Slightly)
Appearance
White to Light Yellow Solid
Application
Used for the resolution of optically active isomers.
Storage
Store at -20°C under inert atmosphere
Vapor Pressure
0.00000007 [mmHg]
Related CAS
76-26-6 (Deleted CAS) 6060-29-3 (Deleted CAS) 27341-43-1 (Deleted CAS) 1210621-65-0 (Deleted CAS) 1212823-93-2 (Deleted CAS) 1235438-68-2 (Deleted CAS) 2299297-58-6 (Deleted CAS) 2434633-96-0 (Deleted CAS) 1209599-88-1 (monohydrate)
Safety Information
Hazards
H314
Precautionary Statement
P260 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338
Signal Word
Danger
Computed Properties
XLogP3
0.5
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
2
Exact Mass
232.07693016 g/mol
Monoisotopic Mass
232.07693016 g/mol
Topological Polar Surface Area
79.8Ų
Heavy Atom Count
15
Formal Charge
0
Complexity
404
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
2
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| US-11000534-B1 | Deuterated derivatives of psilocybin and uses thereof | 2020-10-08 |
| US-10988479-B1 | Morphic forms of trilaciclib and methods of manufacture thereof | 2020-06-15 |
| WO-2021116503-A2 | Deuterated compounds | 2020-06-02 |
| US-2020360675-A1 | Kits for topical,isotonic compositions | 2019-12-23 |
| EP-3842060-A1 | Stapled lactam co-agonists of the glucagon and glp-1 receptors | 2019-12-23 |
| EP-3842061-A1 | Stapled triazole co-agonists of the glucagon and glp-1 receptors | 2019-12-23 |
| EP-3842449-A1 | Stapled olefin co-agonists of the glucagon and glp-1 receptors | 2019-12-23 |
| EP-3838345-A1 | Macrocyclic peptides | 2019-12-20 |
| EP-3838912-A1 | Retro-inverso peptides | 2019-12-20 |
| US-2021186890-A1 | Process of preparing mrna-loaded lipid nanoparticles | 2019-12-20 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22744916 | 2012-10-01 | The syntheses of new camphorsulfonylated ligands derived from 2-amino-2'-hydroxy-1,1'-binaphthyl and their enantioselectivities in the addition of dialkylzinc reagents to aldehydes | Chirality |
| 22889048 | 2012-09-07 | A novel, facile approach to frondosin B and 5-epi-liphagal via a new [4 + 3]-cycloaddition | Organic letters |
| 22548473 | 2012-05-01 | Highly sensitive surface-enhanced Raman spectroscopy (SERS) platforms based on silver nanostructures fabricated on polyaniline membrane surfaces | ACS applied materials & interfaces |
| 22302165 | 2012-04-01 | Electrochemically synthesized polymers in molecular imprinting for chemical sensing | Analytical and bioanalytical chemistry |
| 22248345 | 2012-02-23 | Contribution of phosphates and adenine to the potency of adenophostins at the IP₃ receptor: synthesis of all possible bisphosphates of adenophostin A | Journal of medicinal chemistry |
| 22187426 | 2012-02-17 | Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases | The Journal of biological chemistry |
| 22277278 | 2012-02-15 | Camphorsulfonic acid catalysed facile tandem double Friedlander annulation protocol for the synthesis of phenoxy linked bisquinoline derivatives and discovery of antitubercular agents | Bioorganic & medicinal chemistry letters |
| 22251083 | 2012-02-03 | Mechanistic variations in ionic hydrogenation of unsaturated phosphine and amine boranes | Organic letters |
| 22215085 | 2012-01-03 | Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor | Nature communications |
| 21985870 | 2012-01-01 | Electroactive porous tubular scaffolds with degradability and non-cytotoxicity for neural tissue regeneration | Acta biomaterialia |
