1,2,3,4,5,6-Hexabromocyclohexane

Inquiry

Product Information

Molecular Formula:
C6H6Br6
Molecular Weight:
557.54
Description
1,2,3,4,5,6-Hexabromocyclohexane is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It inhibits JAK2 activation, and reduces growth hormone-mediated JAK2 autophosphorylation.
Synonyms
Benzene Hexabromide; JAK2 Inhibitor II
IUPAC Name
1,2,3,4,5,6-hexabromocyclohexane
Canonical SMILES
C1(C(C(C(C(C1Br)Br)Br)Br)Br)Br
InChI
InChI=1S/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
InChI Key
QFQZKISCBJKVHI-UHFFFAOYSA-N
Melting Point
218.0 to 223.0 °C
Purity
>98%
Appearance
White to Almost white powder to crystal

Safety Information

Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].

Computed Properties

XLogP3
5
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
0
Rotatable Bond Count
0
Exact Mass
557.55083 g/mol
Monoisotopic Mass
551.55698 g/mol
Topological Polar Surface Area
0Ų
Heavy Atom Count
12
Formal Charge
0
Complexity
104
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
WO-2021231274-A1 Methods and systems for analyzing targetable pathologic processes in covid-19 via gene expression analysis 2020-05-11
WO-2021167096-A1 Styrene-based resin composition, flame retardant styrene-based resin composition, molded body, and patch antenna 2020-02-21
WO-2021125340-A1 Medium for culturing and expanding nephron progenitor cells, method for culturing and expanding nephron progenitor cells, and method for producing renal organoids 2019-12-19
EP-3854455-A1 Ttp phosphorylation as a biomarker in targeted therapy 2019-12-11
US-2021177852-A1 Ttp phosphorylation as a biomarker in targeted therapy 2019-12-11
JP-2021075613-A Flame Retardant Masterbatch and Flame Retardant Styrene Resin Composition Using It 2019-11-07
WO-2020212374-A1 Silyl functional compound for improving flame retardant properties 2019-04-16
WO-2020212377-A1 Silyl functional compound for improving flame retardant properties 2019-04-16
WO-2020196096-A1 Foamable polystyrene resin particles, polystyrene pre-foamed particles, and foamed molded product 2019-03-25
JP-2020152816-A Flame-retardant styrene resin composition, molded product, and extruded sheet 2019-03-20

Literatures

PMID Publication Date Title Journal
21490369 2011-07-01 Growth hormone-stimulated insulin-like growth factor-1 expression in rainbow trout (Oncorhynchus mykiss) hepatocytes is mediated by ERK, PI3K-AKT, and JAK-STAT American journal of physiology. Regulatory, integrative and comparative physiology
22649371 2011-01-01 ERK, Akt, and STAT5 are Differentially Activated by the Two Growth Hormone Receptor Subtypes of a Teleost Fish (Oncorhynchus Mykiss) Frontiers in endocrinology
20562009 2010-08-30 Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling Molecular and cellular endocrinology
19234487 2009-04-09 Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients Oncogene
17178722 2007-02-09 Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth The Journal of biological chemistry
15801842 2005-04-07 Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation] Journal of medicinal chemistry
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Calculate
The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Calculate

Related Products

2,3,5,6-Tetrabromo-p-xylene
(CAS 23488-38-2)
meso-1,2,3,4-Tetrabromobutane
(CAS 2657-67-2)
1,2-Bis(pentabromophenyl) ethane
(CAS 84852-53-9)
4,4'-Isopropylidenebis[2-(2,6-dibromophenoxy)ethanol]
(CAS 4162-45-2)
Tris(2,3-dibromopropyl) isocyanurate
(CAS 52434-90-9)
Tetrabromobisphenol A diallyl ether
(CAS 25327-89-3)
Products
Custom Services
Polymer Applications
Automotive
Automotive

BOC Sciences can provide a wide variety of raw materials from upstream lines for automotive parts manufacturing, such as monomers, polymers and additives.

Read More
Composites
Composites

BOC Sciences supplies the necessary raw materials to help you manufacture ideal composites.

Read More
Healthcare
Healthcare

BOC Sciences can help our customers further understand the functionality and applicable requirements for raw materials in different healthcare segments.

Read More
Electronics
Electronics

BOC Sciences' seasoned experts can help you from upstream lines to arrive at the most appropriate solution to improve production and optimize your bottom line.

Read More
Packaging
Packaging

BOC Sciences can help you arrive at an optimal solution to improve your research projects and manufacturing process.

Read More
Customer Support
Customer Support
International
US & Canada (Toll free)
UK

Ask a Question
Online Inquiry
  • Verification code
Navigation
USA
  • International:
  • US & Canada (Toll free):
  • Email:
  • Fax:
UK
  • Email:
Copyright © 2024 BOC Sciences. All rights reserved.
Inquiry Basket
Loading ......
Delete selectedGo to checkout