1,2,3,4,5,6-Hexabromocyclohexane

Product Information

Molecular Formula:
C6H6Br6
Molecular Weight:
557.54
Description
1,2,3,4,5,6-Hexabromocyclohexane is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It inhibits JAK2 activation, and reduces growth hormone-mediated JAK2 autophosphorylation.
Synonyms
Benzene Hexabromide; JAK2 Inhibitor II
IUPAC Name
1,2,3,4,5,6-hexabromocyclohexane
Canonical SMILES
C1(C(C(C(C(C1Br)Br)Br)Br)Br)Br
InChI
InChI=1S/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
InChI Key
QFQZKISCBJKVHI-UHFFFAOYSA-N
Melting Point
218.0 to 223.0 °C
Purity
>98%
Appearance
White to Almost white powder to crystal

Safety Information

Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].

Computed Properties

XLogP3
5
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
0
Rotatable Bond Count
0
Exact Mass
557.55083 g/mol
Monoisotopic Mass
551.55698 g/mol
Topological Polar Surface Area
0Ų
Heavy Atom Count
12
Formal Charge
0
Complexity
104
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
WO-2021231274-A1 Methods and systems for analyzing targetable pathologic processes in covid-19 via gene expression analysis 2020-05-11
WO-2021167096-A1 Styrene-based resin composition, flame retardant styrene-based resin composition, molded body, and patch antenna 2020-02-21
WO-2021125340-A1 Medium for culturing and expanding nephron progenitor cells, method for culturing and expanding nephron progenitor cells, and method for producing renal organoids 2019-12-19
EP-3854455-A1 Ttp phosphorylation as a biomarker in targeted therapy 2019-12-11
US-2021177852-A1 Ttp phosphorylation as a biomarker in targeted therapy 2019-12-11
JP-2021075613-A Flame Retardant Masterbatch and Flame Retardant Styrene Resin Composition Using It 2019-11-07
WO-2020212374-A1 Silyl functional compound for improving flame retardant properties 2019-04-16
WO-2020212377-A1 Silyl functional compound for improving flame retardant properties 2019-04-16
WO-2020196096-A1 Foamable polystyrene resin particles, polystyrene pre-foamed particles, and foamed molded product 2019-03-25
JP-2020152816-A Flame-retardant styrene resin composition, molded product, and extruded sheet 2019-03-20

Literatures

PMID Publication Date Title Journal
21490369 2011-07-01 Growth hormone-stimulated insulin-like growth factor-1 expression in rainbow trout (Oncorhynchus mykiss) hepatocytes is mediated by ERK, PI3K-AKT, and JAK-STAT American journal of physiology. Regulatory, integrative and comparative physiology
22649371 2011-01-01 ERK, Akt, and STAT5 are Differentially Activated by the Two Growth Hormone Receptor Subtypes of a Teleost Fish (Oncorhynchus Mykiss) Frontiers in endocrinology
20562009 2010-08-30 Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling Molecular and cellular endocrinology
19234487 2009-04-09 Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients Oncogene
17178722 2007-02-09 Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth The Journal of biological chemistry
15801842 2005-04-07 Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation] Journal of medicinal chemistry
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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