2-APB

Product Information

Molecular Formula:
C14H16BNO
Molecular Weight:
225.10
Description
2-APB, a transient receptor potential (TRP) activator for TRPV1, TRPV2, and TRPV3, could probably be used against diseases caused by hypersensitivity and temperature misregulation.
Synonyms
2-Aminoethoxydiphenylborane
IUPAC Name
2-diphenylboranyloxyethanamine
Canonical SMILES
B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN
InChI
InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChI Key
BLZVCIGGICSWIG-UHFFFAOYSA-N
Flash Point
Not applicable
Purity
≥98% by HPLC
Appearance
White Solid
Storage
−20°C

Safety Information

Hazards
H315 - H319 - H335
Precautionary Statement
P302 + P352 - P305 + P351 + P338

Computed Properties

Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
5
Exact Mass
225.1324943 g/mol
Monoisotopic Mass
225.1324943 g/mol
Topological Polar Surface Area
35.2Ų
Heavy Atom Count
17
Formal Charge
0
Complexity
182
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-113546086-A Application of 2-APB in preparation of medicine for promoting skin wound healing 2021-09-10
CN-112426425-A Use of citrusinine-II for the preparation of agents affecting the perception of itch and pain in humans and animals 2020-11-20
CN-112426425-B Use of citrusinine-II for the preparation of agents affecting the perception of itch and pain in humans and animals 2020-11-20
WO-2021248160-A1 Methods of treatment of a cytokine storm 2020-06-01
FR-3110393-A1 COMPOUND AND COMPOSITION TO INDUCE NEUROPROTECTION 2020-05-20
WO-2021234324-A1 Compound and composition for inducing neuroprotection 2020-05-20
US-2021363163-A1 Organic electroluminescent materials and devices 2020-05-13
EP-3910030-A1 Bioinspired fluorescent stains for reversible labelling of the endoplasmic reticulum and for further analytical applications 2020-05-11
WO-2021228776-A1 Bioinspired fluorescent probes for reversible staining of the endoplasmic reticulum and for further analytical applications 2020-05-11
JP-2021172628-A Selective TRP channel activators and their uses 2020-04-28

Literatures

PMID Publication Date Title Journal
34516972 2021-10-01 Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca2+ homeostasis Chemico-biological interactions
33408296 2021-01-01 Bisphenol A stabilizes Nrf2 via Ca2+ influx by direct activation of the IP3 receptor The Journal of toxicological sciences
32578922 2020-11-01 Perfluorooctanoic acid activates the unfolded protein response in pancreatic acinar cells Journal of biochemical and molecular toxicology
32522522 2020-08-01 Ca2+/CaM/CaMK signaling is involved in cadmium-induced osteoclast differentiation Toxicology
31982503 2020-05-01 ZEA-induced autophagy in TM4 cells was mediated by the release of Ca2+ activates CaMKKβ-AMPK signaling pathway in the endoplasmic reticulum Toxicology letters
30229906 2019-04-01 A critical role of the transient receptor potential melastatin 2 channel in a positive feedback mechanism for reactive oxygen species-induced delayed cell death Journal of cellular physiology
30615643 2019-01-01 TRPM7 residue S1269 mediates cAMP dependence of Ca2+ influx PloS one
30076216 2018-09-14 TRPM7 channels play a role in high glucose-induced endoplasmic reticulum stress and neuronal cell apoptosis The Journal of biological chemistry
29883672 2018-08-01 CaMKⅡ mediates cadmium induced apoptosis in rat primary osteoblasts through MAPK activation and endoplasmic reticulum stress Toxicology
28347754 2017-05-15 Cadmium disrupts autophagic flux by inhibiting cytosolic Ca2+-dependent autophagosome-lysosome fusion in primary rat proximal tubular cells Toxicology
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Related Products

Online Inquiry
  • Verification code
USA
  • International:
  • US & Canada (Toll free):
  • Email:
  • Fax:
UK
  • Email:
Copyright © 2025 BOC Sciences. All rights reserved.
Top
Inquiry Basket