2-Fluoro-4-biphenylylboronic acid
Product Information
Molecular Formula
C12H10O2BF
Molecular Weight
216.02
Description
2-Fluoro-4-biphenylylboronic acid is a boronic acid derivative commonly used in biomedical research. It is a versatile reagent in Suzuki cross-coupling reactions utilized in the synthesis of several pharmaceutical drugs designed to treat cardiovascular diseases and certain types of cancer.
Synonyms
RARECHEM AH PB 0063; AKOS BRN-0162; 3-FLUOROBIPHENYL; 3-FLUORO-4-PHENYLBENZENEBORONIC ACID; 2-FLUOROBIPHENYL-4-BORONIC ACID; 2-FLUORO[1,1'-BIPHENYL]-4-BORONIC ACID
IUPAC Name
(3-fluoro-4-phenylphenyl)boronic acid
SMILES
B(C1=CC(=C(C=C1)C2=CC=CC=C2)F)(O)O
InChI
InChI=1S/C12H10BFO2/c14-12-8-10(13(15)16)6-7-11(12)9-4-2-1-3-5-9/h1-8,15-16H
InChI Key
BWYWXDFYJSIUBE-UHFFFAOYSA-N
Boiling Point
377.3°C at 760mmHg
Melting Point
243-248°C
Purity
98%
Density
1.25g/cm3
Computed Properties
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
2
Exact Mass
216.0757879 g/mol
Monoisotopic Mass
216.0757879 g/mol
Topological Polar Surface Area
40.5Ų
Heavy Atom Count
16
Formal Charge
0
Complexity
219
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2020225330-A1 | Dhodh inhibitors and their use as antiviral agents | 2019-05-07 |
| EP-3965753-A1 | Dhodh inhibitors and their use as antiviral agents | 2019-05-07 |
| JP-2018170236-A | Nonaqueous electrolyte for batteries and lithium secondary battery | 2017-03-30 |
| JP-6884020-B2 | Non-aqueous electrolyte for batteries and lithium secondary battery | 2017-03-30 |
| JP-2018170487-A | Photoelectric conversion element for image sensor | 2016-09-13 |
| JP-6986887-B2 | Photoelectric conversion element for image sensor | 2016-09-13 |
| JP-2018166200-A | Photoelectric conversion element for image sensor | 2016-08-30 |
| JP-6906388-B2 | Photoelectric conversion element for image sensor | 2016-08-30 |
| CN-108368142-A | The manufacturing method and palladium complex of aromatic compound | 2015-12-02 |
| EP-3385270-A1 | Method for producing aromatic compound, and palladium complex | 2015-12-02 |
