Copovidone

Inquiry

Molecular Formula:

(C6H9NO.C4H6O2)x

Molecular Weight:

~25000

CAS Number:

25086-89-9

Catalog Number:

25086-89-9

Product Information

Molecular Formula:

(C6H9NO.C4H6O2)x

Molecular Weight:

~25000

Description

Copovidone, a water-soluble polymer, is commonly used to improve the uptake and drug loading of various pharmaceutical agents.

Synonyms

Acetic acid ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone; Poly(1-vinylpyrrolidone-co-vinyl acetate); PVP/VA copolymer; 2-Pyrrolidinone, 1-ethenyl-, polymer with ethenyl acetate; 2-Pyrrolidinone, 1-vinyl-, polymer with vinyl acetate; Acetic acid vinyl ester, polymer with 1-vinyl-2-pyrrolidinone; 1-Vinyl-2-Pyrrolidinone-vinyl acetate copolymer; 1-Vinylpyrrolidone-vinyl acetate copolymer; Agrimer VA 03E; Copolyvidon; Copovidon; DimaFIX; E 335 (polymer); N-Vinylpyrrolidone-vinyl acetate copolymer; NSC 114023; Poly(N-vinylpyrrolidone-vinyl acetate); Poly(vinyl acetate-co-vinyl pyrrolidone); Poly(vinylpyrrolidone-vinyl acetate); Povidone-vinyl acetate copolymer; Vinylpyrrolidone-vinyl acetate copolymer; W 635 (vinyl polymer)

Canonical SMILES

CC(=O)OC=C.C=CN1CCCC1=O

InChI

InChI=1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3

InChI Key

FYUWIEKAVLOHSE-UHFFFAOYSA-N

Density

0.955 g/cm3

Solubility

Soluble in Water (Slightly)

Appearance

White Solid

Storage

Store at RT

Concentration

50% soln. in isopropanol

108°

Stability

Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.

Safety Information

Hazards

Irritant

Handling

Glove. chemical goggles & fume hood

Precautionary Statement

P261 P305+P351+P338

Computed Properties

Hydrogen Bond Donor Count

Hydrogen Bond Acceptor Count

Rotatable Bond Count

Exact Mass

197.10519334 g/mol

Monoisotopic Mass

197.10519334 g/mol

Topological Polar Surface Area

46.6Å²

Heavy Atom Count

Formal Charge

Complexity

186

Isotope Atom Count

Defined Atom Stereocenter Count

Undefined Atom Stereocenter Count

Defined Bond Stereocenter Count

Undefined Bond Stereocenter Count

Covalently-Bonded Unit Count

Compound Is Canonicalized

Yes

Patents

Publication Number	Title	Priority Date
CN-113861750-A	Anti-curling ink and preparation method thereof	2021-11-17
CN-113773703-A	Anti-adhesion gloss oil for cigarette tipping paper and preparation method and application thereof	2021-10-26
CN-113768081-A	Method for removing nitrite in cubilose	2021-09-14
CN-113441018-A	Preparation method of polyvinylidene fluoride hollow fiber ultrafiltration membrane	2021-08-06
CN-113577022-A	Dapsone compound suspension and preparation method and application thereof	2021-05-18
CN-113198335-A	Polyvinylidene fluoride hollow fiber ultrafiltration membrane and preparation method thereof	2021-04-21
CN-113057946-A	Dihydroartemisinin piperaquine tablet and preparation method thereof	2021-03-30
WO-2022053697-A1	Fgfr inhibitor combination therapies	2020-09-14
US-11266641-B1	Formulations of a somatostatin modulator	2020-09-09
US-2022071986-A1	Formulations of a somatostatin modulator	2020-09-09

Literatures

PMID	Publication Date	Title	Journal
22592919	2012-08-01	Mechanistic insights into the dissolution of spray-dried amorphous solid dispersions	Journal of pharmaceutical sciences
22440149	2012-06-15	Application of mixtures of polymeric carriers for dissolution enhancement of fenofibrate using hot-melt extrusion	International journal of pharmaceutics
22101292	2012-01-17	MDSC parameter optimization for the determination of glass transitions using a design of experiments approach	International journal of pharmaceutics
22023866	2011-11-14	Pyrolysis-gas chromatography-mass spectrometry for studying N-vinyl-2-pyrrolidone-co-vinyl acetate copolymers and their dissolution behaviour	Analytica chimica acta
21417606	2011-08-01	Nimodipine (NM) tablets with high dissolution containing NM solid dispersions prepared by hot-melt extrusion	Drug development and industrial pharmacy
21290385	2011-07-01	Nanoparticle formation and growth during in vitro dissolution of ketoconazole solid dispersion	Journal of pharmaceutical sciences
21374603	2011-05-01	The inhibition effect of high storage temperature on the recrystallization rate during dissolution of nimodipine-Kollidon VA64 solid dispersions (NM-SD) prepared by hot-melt extrusion	Journal of pharmaceutical sciences
21468924	2011-01-01	Solid dispersion formulations of megestrol acetate with copovidone for enhanced dissolution and oral bioavailability	Archives of pharmacal research
19052850	2009-04-01	Solubility of small-molecule crystals in polymers: D-mannitol in PVP, indomethacin in PVP/VA, and nifedipine in PVP/VA	Pharmaceutical research
18582567	2008-10-01	Evaluation of the formulation of solid dispersions by co-spray drying itraconazole with Inutec SP1, a polymeric surfactant, in combination with PVPVA 64	European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight *

Calculate

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)