Copovidone
Product Information
Molecular Formula
(C6H9NO.C4H6O2)x
Molecular Weight
~25000
Description
Copovidone, a water-soluble polymer, is commonly used to improve the uptake and drug loading of various pharmaceutical agents.
Synonyms
Acetic acid ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone; Poly(1-vinylpyrrolidone-co-vinyl acetate); PVP/VA copolymer; 2-Pyrrolidinone, 1-ethenyl-, polymer with ethenyl acetate; 2-Pyrrolidinone, 1-vinyl-, polymer with vinyl acetate; Acetic acid vinyl ester, polymer with 1-vinyl-2-pyrrolidinone; 1-Vinyl-2-Pyrrolidinone-vinyl acetate copolymer; 1-Vinylpyrrolidone-vinyl acetate copolymer; Agrimer VA 03E; Copolyvidon; Copovidon; DimaFIX; E 335 (polymer); N-Vinylpyrrolidone-vinyl acetate copolymer; NSC 114023; Poly(N-vinylpyrrolidone-vinyl acetate); Poly(vinyl acetate-co-vinyl pyrrolidone); Poly(vinylpyrrolidone-vinyl acetate); Povidone-vinyl acetate copolymer; Vinylpyrrolidone-vinyl acetate copolymer; W 635 (vinyl polymer)
SMILES
CC(=O)OC=C.C=CN1CCCC1=O
InChI
InChI=1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
InChI Key
FYUWIEKAVLOHSE-UHFFFAOYSA-N
Density
0.955 g/cm3
Solubility
Soluble in Water (Slightly)
Appearance
White Solid
Storage
Store at RT
Concentration
50% soln. in isopropanol
Tg
108°
Stability
Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.
Related CAS
8013-98-7 (Deleted CAS) 37359-37-8 (Deleted CAS) 89335-67-1 (Deleted CAS) 1257874-67-1 (Deleted CAS) 1427441-60-8 (Deleted CAS) 1832636-70-0 (Deleted CAS)
Safety Information
Hazards
Irritant
Handling
Glove. chemical goggles & fume hood
Precautionary Statement
P261 P305+P351+P338
Computed Properties
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
3
Exact Mass
197.10519334 g/mol
Monoisotopic Mass
197.10519334 g/mol
Topological Polar Surface Area
46.6Ų
Heavy Atom Count
14
Formal Charge
0
Complexity
186
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
2
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-113861750-A | Anti-curling ink and preparation method thereof | 2021-11-17 |
| CN-113773703-A | Anti-adhesion gloss oil for cigarette tipping paper and preparation method and application thereof | 2021-10-26 |
| CN-113768081-A | Method for removing nitrite in cubilose | 2021-09-14 |
| CN-113441018-A | Preparation method of polyvinylidene fluoride hollow fiber ultrafiltration membrane | 2021-08-06 |
| CN-113577022-A | Dapsone compound suspension and preparation method and application thereof | 2021-05-18 |
| CN-113198335-A | Polyvinylidene fluoride hollow fiber ultrafiltration membrane and preparation method thereof | 2021-04-21 |
| CN-113057946-A | Dihydroartemisinin piperaquine tablet and preparation method thereof | 2021-03-30 |
| WO-2022053697-A1 | Fgfr inhibitor combination therapies | 2020-09-14 |
| US-11266641-B1 | Formulations of a somatostatin modulator | 2020-09-09 |
| US-2022071986-A1 | Formulations of a somatostatin modulator | 2020-09-09 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22592919 | 2012-08-01 | Mechanistic insights into the dissolution of spray-dried amorphous solid dispersions | Journal of pharmaceutical sciences |
| 22440149 | 2012-06-15 | Application of mixtures of polymeric carriers for dissolution enhancement of fenofibrate using hot-melt extrusion | International journal of pharmaceutics |
| 22101292 | 2012-01-17 | MDSC parameter optimization for the determination of glass transitions using a design of experiments approach | International journal of pharmaceutics |
| 22023866 | 2011-11-14 | Pyrolysis-gas chromatography-mass spectrometry for studying N-vinyl-2-pyrrolidone-co-vinyl acetate copolymers and their dissolution behaviour | Analytica chimica acta |
| 21417606 | 2011-08-01 | Nimodipine (NM) tablets with high dissolution containing NM solid dispersions prepared by hot-melt extrusion | Drug development and industrial pharmacy |
| 21290385 | 2011-07-01 | Nanoparticle formation and growth during in vitro dissolution of ketoconazole solid dispersion | Journal of pharmaceutical sciences |
| 21374603 | 2011-05-01 | The inhibition effect of high storage temperature on the recrystallization rate during dissolution of nimodipine-Kollidon VA64 solid dispersions (NM-SD) prepared by hot-melt extrusion | Journal of pharmaceutical sciences |
| 21468924 | 2011-01-01 | Solid dispersion formulations of megestrol acetate with copovidone for enhanced dissolution and oral bioavailability | Archives of pharmacal research |
| 19052850 | 2009-04-01 | Solubility of small-molecule crystals in polymers: D-mannitol in PVP, indomethacin in PVP/VA, and nifedipine in PVP/VA | Pharmaceutical research |
| 18582567 | 2008-10-01 | Evaluation of the formulation of solid dispersions by co-spray drying itraconazole with Inutec SP1, a polymeric surfactant, in combination with PVPVA 64 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V |
