Poly(N-isopropyl acrylamide)
Product Information
Molecular Formula
(C6H11NO)n
Description
Poly(N-isopropyl acrylamide) is a thermoresponsive polymer used in biomedical and pharmaceutical applications, particularly for controlled drug delivery and tissue engineering.
Synonyms
Nipam; N-Iso-Propylacrylamide; N-Isopropyl acrylamide; 2-Propenamide, N-(1-methylethyl)-; Isopropyl acrylamide; Acrylamide, N-isopropyl-; N-(1-Methylethyl)-2-propenamide; Isopropylamid kyseliny akrylove; N-(propan-2-yl)prop-2-enamide; N-sopropylacrylamde; N-Isopropylacrylamide
SMILES
CC(C)NC(=O)C=C
InChI
InChI=1S/C6H11NO/c1-4-6(8)7-5(2)3/h4-5H,1H2,2-3H3,(H,7,8)
InChI Key
QNILTEGFHQSKFF-UHFFFAOYSA-N
Melting Point
>200 °C
Solubility
In water, 3.077 X 10+4 mg/L at 25 °C (est)
Appearance
Crystalline solid
Application
Used in binders for textiles, paper, adhesives, detergents, and cosmetics.
Storage
Store at room temperature
Tg
85°
Stability
Stable under recommended storage conditions.
LogP
log Kow = 0.57 (est)
Vapor Pressure
0.02 [mmHg]
Henry's Law Constant
2.28X10-8 atm-cu m/mol at 25 °C (est)
Decomposition
Hazardous decomposition products /formed under fire conditions/: Carbon oxides, nitrogen oxides (NOx)
Safety Information
Hazards
Harmless-use normal precautions
Handling
Exercise normal care
Computed Properties
XLogP3
0.9
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
1
Rotatable Bond Count
2
Exact Mass
113.084063974 g/mol
Monoisotopic Mass
113.084063974 g/mol
Topological Polar Surface Area
29.1Ų
Heavy Atom Count
8
Formal Charge
0
Complexity
96.7
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114031329-A | Concrete repair material, concrete repair coating and preparation method thereof | 2022-01-11 |
| CN-114015012-A | High polymer grouting material for pavement construction and preparation method thereof | 2022-01-06 |
| JP-2022031470-A | Method for producing sheet-shaped cell culture | 2021-12-27 |
| CN-114149571-A | Imidazole ionic liquid catalyzed vinyl monomer and cyclic ester monomer hybrid polymerization method | 2021-12-23 |
| CN-113999476-A | Dual-stimulus-responsive conductive composite hydrogel and preparation method and application thereof | 2021-12-21 |
| CN-114015080-A | Preparation method and application of inorganic/organic composite hydrogel driver | 2021-12-21 |
| CN-114133486-A | Bionic anisotropic hybrid cross-linked hydrogel and preparation method and application thereof | 2021-12-21 |
| CN-114163664-A | Preparation method and application of universal double-layer hydrogel driver | 2021-12-21 |
| CN-114053488-A | Durable lubricating coating on surface of medical catheter and preparation method thereof | 2021-12-17 |
| CN-114105703-A | Slow-release antibacterial amino acid water-soluble fertilizer and preparation method thereof | 2021-12-17 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 28930445 | 2017-11-13 | Thermoresponsive and Active Functional Fiber Mats for Cultured Cell Recovery | Biomacromolecules |
| 22589075 | 2012-12-01 | ARGET-ATRP synthesis and characterization of PNIPAAm brushes for quantitative cell detachment studies | Biointerphases |
| 22939253 | 2012-12-01 | Effect of grafting architecture on the surfactant-like behavior of clay-poly(NiPAAm) nanohybrids | Journal of colloid and interface science |
| 23109107 | 2012-12-01 | How to control the recombinant prion protein adhesion for successful storage through modification of surface properties | Biointerphases |
| 22915556 | 2012-11-14 | Shell cross-linking of cyclodextrin-based micelles via supramolecular chemistry for the delivery of drugs | Macromolecular rapid communications |
| 22019050 | 2012-11-01 | Self-oscillating surface of gel for autonomous mass transport | Colloids and surfaces. B, Biointerfaces |
| 22143027 | 2012-11-01 | Modulation of graft architectures for enhancing hydrophobic interaction of biomolecules with thermoresponsive polymer-grafted surfaces | Colloids and surfaces. B, Biointerfaces |
| 22813847 | 2012-11-01 | Thermally responsive microcarriers with optimal poly(N-isopropylacrylamide) grafted density for facilitating cell adhesion/detachment in suspension culture | Acta biomaterialia |
| 22786875 | 2012-10-26 | Amine-reactive polymers synthesized by RAFT polymerization using an azlactone functional trithiocarbonate RAFT agent | Macromolecular rapid communications |
| 23013607 | 2012-10-24 | Surface modification of siliceous materials using maleimidation and various functional polymers synthesized by reversible addition-fragmentation chain transfer polymerization | ACS applied materials & interfaces |
