Glyceryl tributyrate

Product Information

Molecular Formula:
C15H26O6
Molecular Weight:
302.36
Description
Tributyrin is a triglyceride existing in butter. Tributyrin is a prodrug of butyric acid to enhance antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells, and it is used to identify the bacterium Moraxella catarrhalis in microbiological laboratories.
Synonyms
2,3-di(butanoyloxy)propyl butanoate
IUPAC Name
2,3-di(butanoyloxy)propyl butanoate
Canonical SMILES
CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC
InChI
InChI=1S/C15H26O6/c1-4-7-13(16)19-10-12(21-15(18)9-6-3)11-20-14(17)8-5-2/h12H,4-11H2,1-3H3
InChI Key
UYXTWWCETRIEDR-UHFFFAOYSA-N
Boiling Point
190 ℃ / 15 mmHg
Melting Point
-75 ℃
Flash Point
180 °C
Purity
95 %
Density
1.04 g/cm3
Solubility
Sol in acetone, Benzene
Appearance
Liquid
Refractive Index
1.44
LogP
2.38490
Vapor Pressure
1.3X10-3 mm Hg at 25 °C
Henry's Law Constant
9.6X10-9 atm cu m/mole at 25 °C /Estimated/
Decomposition
When heated to decomposition it emits acrid smoke and fumes
Odor
FRUITY, BUTTERY

Computed Properties

XLogP3
2.4
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Rotatable Bond Count
14
Exact Mass
302.17293854 g/mol
Monoisotopic Mass
302.17293854 g/mol
Topological Polar Surface Area
78.9Ų
Heavy Atom Count
21
Formal Charge
0
Complexity
304
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-114181874-A Deep-sea micro bacillus and application thereof in enhancing flavor of aquatic seasoning 2022-02-16
CN-114181922-A Recombinant esterase, gene, recombinant bacterium and application of recombinant esterase to degradation of phthalate 2021-12-10
CN-114041542-A Feed additive for promoting piglet gastrointestinal health and preparation method thereof 2021-12-08
CN-113913347-A Paenibacillus balun TZ-1 and application thereof 2021-11-24
CN-114027414-A Traditional Chinese medicine esterase composition for laying hens and application thereof 2021-11-20
CN-114027097-A Mushroom culture medium containing nut green seedcase and preparation method thereof 2021-11-19
CN-113843549-A Silver soldering paste sintering aid and preparation method and application thereof 2021-11-18
CN-114107250-A Lipase CALBgold and preparation method and application thereof 2021-11-18
CN-114081990-A Traditional Chinese medicine composite temperature-sensitive gel embolic agent as well as preparation method and application thereof 2021-11-17
CN-113999793-A Lactobacillus plantarum with good fermentation characteristics and fragrance production function and screening method thereof 2021-11-12

Literatures

PMID Publication Date Title Journal
30503584 2019-01-15 Enhancement of mouse contact hypersensitivity appears with a short chain triacylglycerol but not with a long chain one Toxicology
29198882 2018-03-01 Adjuvant effect of short chain triacylglycerol tributyrin on a mouse contact hypersensitivity model Toxicology letters
21940155 2012-08-01 Chemopreventive effects of the dietary histone deacetylase inhibitor tributyrin alone or in combination with vitamin A during the promotion phase of rat hepatocarcinogenesis The Journal of nutritional biochemistry
22621868 2012-07-15 Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice American journal of physiology. Endocrinology and metabolism
22362134 2012-06-01 Modulation of histone deacetylase attenuates naloxone-precipitated opioid withdrawal syndrome Naunyn-Schmiedeberg's archives of pharmacology
22405988 2012-05-30 Dual function of tributyrin emulsion: solubilization and enhancement of anticancer effect of celecoxib International journal of pharmaceutics
22426713 2012-01-01 High-throughput screening method for lipases/esterases Methods in molecular biology (Clifton, N.J.)
22426724 2012-01-01 Purification, biochemical and kinetic properties of recombinant Staphylococcus aureus lipase Methods in molecular biology (Clifton, N.J.)
22426727 2012-01-01 Molecular modeling of lipase binding to a substrate-water interface Methods in molecular biology (Clifton, N.J.)
22082136 2011-12-14 Enzymatically catalyzed synthesis of low-calorie structured lipid in a solvent-free system: optimization by response surface methodology Journal of agricultural and food chemistry
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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