Pyridine-2,6-bis(carboximidamide) dihydrochloride

Product Information

Molecular Formula:
C7H11Cl2N5
Molecular Weight:
236.10
Description
This pyridyl carboxamidine ligand has been demonstrated by Daniel Weix's lab to enable nickel-catalyzed cross-coupling of diverse basic nitrogen heterocycles with primary and secondary alkyl halides.
Synonyms
Weix 2-pyridylcarboxamidine ligand for nickel catalysis
IUPAC Name
pyridine-2,6-dicarboximidamidedihydrochloride
Canonical SMILES
C1=CC(=NC(=C1)C(=N)N)C(=N)N.Cl.Cl
InChI
InChI=1S/C7H9N5.2ClH/c8-6(9)4-2-1-3-5(12-4)7(10)11/h1-3H,(H3,8,9)(H3,10,11)2*1H
InChI Key
YLMVDWSPWFNTRJ-UHFFFAOYSA-N
Flash Point
Not applicable
Purity
≥95%

Computed Properties

Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
2
Exact Mass
235.0391508 g/mol
Monoisotopic Mass
235.0391508 g/mol
Topological Polar Surface Area
113Ų
Heavy Atom Count
14
Formal Charge
0
Complexity
180
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
3
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
WO-2020165834-A1 Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof 2019-02-15
AU-2020222346-A1 Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof 2019-02-15
CA-3123519-A1 Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof 2019-02-15
AU-2020222346-B2 Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof 2019-02-15
EP-3924055-A1 Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof 2019-02-15
US-2020255403-A1 5-alkyl pyrrolidine orexin receptor agonists 2019-02-13
WO-2020167706-A1 5-alkyl pyrrolidine orexin receptor agonists 2019-02-13
EP-3924058-A1 5-alkyl pyrrolidine orexin receptor agonists 2019-02-13
US-2022017525-A1 Cyclobutyl pyrazolopyrimidine pde9 inhibitors 2018-12-12
WO-2020092136-A1 N-heteroaryl indazole derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof 2018-10-31
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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