Spermine tetrahydrochloride

Inquiry

Molecular Formula:

C10H26N4.4HCl

Molecular Weight:

348.19

CAS Number:

306-67-2

Catalog Number:

306-67-2

Product Information

Molecular Formula:

C10H26N4.4HCl

Molecular Weight:

348.19

Description

Spermine tetrahydrochloride is a polyamine that binds to and modulates NMDA receptor channel. Spermine also acts as a GluR inhibitor, PLCα inhibitor and PLCδ activator.

Synonyms

N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride; Neuridine tetrahydrochloride; Musculamine tetrahydrochloride

IUPAC Name

N,N'-bis(3-aminopropyl)butane-1,4-diaminetetrahydrochloride

Canonical SMILES

C(CCNCCCN)CNCCCN.Cl.Cl.Cl.Cl

InChI

InChI=1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

InChI Key

XLDKUDAXZWHPFH-UHFFFAOYSA-N

Melting Point

310-311 °C (dec.)(lit.)

Purity

>98.0%(T)(N)

Density

1.01 g/mL at 20 °C

Appearance

White to Almost white powder to crystal

Application

Found widely in nature and essential for tissue growth; Used as a tool in biochemical research; Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells. Formed from spermidine, it is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. . . . Spermine is associated with nucleic acids and is thought to stabilize helical structure, in particular, in viruses.

Safety Information

Hazards

H315:
Causes skin irritation.
H319:
Causes serious eye irritation.

Precautionary Statement

P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].

Computed Properties

Hydrogen Bond Donor Count

Hydrogen Bond Acceptor Count

Rotatable Bond Count

Exact Mass

348.119508 g/mol

Monoisotopic Mass

346.122458 g/mol

Topological Polar Surface Area

76.1Å²

Heavy Atom Count

Formal Charge

Complexity

86.1

Isotope Atom Count

Defined Atom Stereocenter Count

Undefined Atom Stereocenter Count

Defined Bond Stereocenter Count

Undefined Bond Stereocenter Count

Covalently-Bonded Unit Count

Compound Is Canonicalized

Yes

Patents

Publication Number	Title	Priority Date
CN-114146087-A	Application of hirsutine in medicine for treating thrombocytopenia	2021-12-08
KR-20210048446-A	Method for preparing fermented rice bran by using weissella koreensis and fermented rice bran prepared thereby	2021-01-19
US-2021401013-A1	Sweet protein from truffle	2020-06-25
WO-2021263158-A1	Sweet protein from truffle	2020-06-25
WO-2021222333-A1	Kras specific antibodies and uses thereof	2020-04-30
CN-111500571-A	Eukaryotic DNA extraction method suitable for Hi-C technology, rinsing liquid and application	2020-04-08
WO-2021152584-A1	Methods of analyzing cell membranes	2020-01-28
KR-20210048110-A	Method for preparing fermented rice bran by using weissella koreensis and fermented rice bran prepared thereby	2019-10-23
WO-2021053623-A1	Automated solution dispenser	2019-09-18
WO-2020209803-A1	A ribozyme comprising a target-binding domain	2019-04-12

Literatures

PMID	Publication Date	Title	Journal
20925391	2010-11-11	Targeting the polyamine transport system with benzazepine- and azepine-polyamine conjugates	Journal of medicinal chemistry

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The dilution calculator equation

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