Cyclen

Product Information

Molecular Formula:
C8H24N4
Molecular Weight:
172.27
Description
Cyclen is an azamocrocycle, which can be used in the development of fluorescent nanosensors for the detection of metal ions.
Synonyms
1,4,7,10-Tetraazacyclododecane; cyclen (1,4,7,10-tetraazacyclododecane)
IUPAC Name
1,4,7,10-tetrazacyclododecane
Canonical SMILES
C1CNCCNCCNCCN1
InChI
InChI=1S/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2
InChI Key
QBPPRVHXOZRESW-UHFFFAOYSA-N
Melting Point
110-113 ℃ (lit.)
Flash Point
Not applicable
Purity
>98%
Appearance
Powder

Safety Information

Hazards
H302 - H312 - H314 - H410
Precautionary Statement
P273 - P280 - P305 + P351 + P338 - P310 - P501

Computed Properties

XLogP3
-2.4
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
0
Exact Mass
172.16879665 g/mol
Monoisotopic Mass
172.16879665 g/mol
Topological Polar Surface Area
48.1Ų
Heavy Atom Count
12
Formal Charge
0
Complexity
65.1
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-114116537-A Method and device for adaptively fusing address and instruction cache 2021-11-25
CN-114169154-A Expansive force prediction method, expansive force prediction system, electronic device, and storage medium 2021-11-25
CN-113929102-A Method for preparing high-purity silicic acid by using chelation principle 2021-11-24
CN-113999185-A Preparation method of high-purity Magnetic Resonance Imaging (MRI) drug intermediate 2021-11-18
CN-114028590-A Granzyme B targeting complex, radiopharmaceutical, preparation methods and applications thereof 2021-11-18
CN-114014843-A PSMA (patterned beam-selective membrane antigen) targeted nuclide/fluorescent bimodal ligand, molecular probe and application 2021-11-17
CN-114071781-A Wireless local area network medium access control method 2021-11-16
CN-114163499-A Cadherin inhibitor and preparation method and application thereof 2021-11-11
CN-114034629-A Rock mass dry-wet circulation damage monitoring system and method in chemical corrosion environment 2021-11-10
CN-114170472-A Image processing method, readable storage medium and computer terminal 2021-10-19

Literatures

PMID Publication Date Title Journal
23613345 2013-06-10 A cyclen-based tetraphosphinate chelator for the preparation of radiolabeled tetrameric bioconjugates Chemistry (Weinheim an der Bergstrasse, Germany)
22996043 2012-11-18 A chirality rewriting cycle mediated by a dynamic cyclen-calcium complex Chemical communications (Cambridge, England)
22974321 2012-10-01 New trick for an old ligand! The sensing of Zn(II) using a lanthanide based ternary Yb(III)-cyclen-8-hydroxyquinoline system as a dual emissive probe for displacement assay Inorganic chemistry
22825538 2012-09-07 Intracomplex general acid/base catalyzed cleavage of RNA phosphodiester bonds: the leaving group effect Organic & biomolecular chemistry
22928524 2012-09-07 Argentivorous molecules: structural evidence for Ag(+)-π interactions in solution Organic letters
22821878 2012-09-01 DOTAM-type ligands possessing arginine pendant groups for use in PARACEST MRI Contrast media & molecular imaging
22658660 2012-07-06 Cation separation and preconcentration using columns containing cyclen and cyclen-resorcinarene derivatives Journal of chromatography. A
22651379 2012-06-18 Monopicolinate cyclen and cyclam derivatives for stable copper(II) complexation Inorganic chemistry
22321835 2012-06-01 Cationic lipids containing cyclen and ammonium moieties as gene delivery vectors Chemical biology & drug design
22507054 2012-05-07 Structural basis for bifunctional zinc(II) macrocyclic complex recognition of thymine bulges in DNA Inorganic chemistry
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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