Dithio-bis-maleimidoethane

Inquiry

Molecular Formula:

C12H12N2O4S2

Molecular Weight:

312.36

CAS Number:

71865-37-7

Catalog Number:

71865-37-7

Product Information

Molecular Formula:

C12H12N2O4S2

Molecular Weight:

312.36

Description

Dithio-bis-maleimidoethane is a highly necessary and groundbreaking biomedical agent. It is widely used in innovative research efforts on drug delivery and antibody-drug conjugates.

Synonyms

1,1'-(Dithiodi-2,1-ethanediyl)bis-1H-pyrrole-2,5-dione; 1-[2-[[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]dithio]ethyl]-1H-pyrrole-2,5-dione;
DTME

IUPAC Name

1-[2-[2-(2,5-dioxopyrrol-1-yl)ethyldisulfanyl]ethyl]pyrrole-2,5-dione

Canonical SMILES

C1=CC(=O)N(C1=O)CCSSCCN2C(=O)C=CC2=O

InChI

InChI=1S/C12H12N2O4S2/c15-9-1-2-10(16)13(9)5-7-19-20-8-6-14-11(17)3-4-12(14)18/h1-4H,5-8H2

InChI Key

SGVWDRVQIYUSRA-UHFFFAOYSA-N

Boiling Point

518.6±35.0 °C(Predicted)

Melting Point

124°C

Purity

>98.0%(HPLC)(N)

Density

1.511±0.06 g/cm3(Predicted)

Appearance

White Solid

Application

A sulfhydryl reactive homobifunctional crosslinking reagent.

Spacer Arm: 13.3 Angstroms

Storage

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Safety Information

Hazards

H315:
Causes skin irritation.
H319:
Causes serious eye irritation.

Precautionary Statement

P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].

Computed Properties

XLogP3

-0.6

Hydrogen Bond Donor Count

Hydrogen Bond Acceptor Count

Rotatable Bond Count

Exact Mass

312.02384922 g/mol

Monoisotopic Mass

312.02384922 g/mol

Topological Polar Surface Area

125Å²

Heavy Atom Count

Formal Charge

Complexity

434

Isotope Atom Count

Defined Atom Stereocenter Count

Undefined Atom Stereocenter Count

Defined Bond Stereocenter Count

Undefined Bond Stereocenter Count

Covalently-Bonded Unit Count

Compound Is Canonicalized

Yes

Patents

Publication Number	Title	Priority Date
JP-6981522-B1	Thermosetting resin composition and its use	2020-12-15
KR-20210121422-A	Method for producing polymer crosslinked product in molten state and polymer crosslinked product prepared thereby	2020-03-30
JP-2021105171-A	Thermosetting hard coat, laminated film, and decorative moldings	2019-12-26
JP-6904474-B1	Thermosetting hard coat, laminated film, and decorative moldings	2019-12-26
WO-2021132631-A1	Thermally curable hardcoat agent, layered film, and decorated molded object	2019-12-26
WO-2020196764-A1	Alkali-soluble polyimide and production method thereof, negative-type photosensitive resin composition, cured film, and production method of pattern cured film	2019-03-27
JP-6636220-B1	Liquid curable resin composition, stator coil, rotating electric machine, and method for detecting abnormal overheating of rotating electric machine	2019-01-15
WO-2020148801-A1	Curable liquid resin composition, stator coil, dynamo-electric machine and method for detecting occurrence of abnormal overheating of dynamo-electric machine	2019-01-15
EP-3533844-A1	Inkjet inks for manufacturing printed circuit boards	2018-03-02
JP-2019116614-A	Thermosetting hard coating agent, laminated film, and decorated molded body	2017-12-26

Literatures

PMID	Publication Date	Title	Journal
18326496	2008-05-02	Cardiolipin controls the osmotic stress response and the subcellular location of transporter ProP in Escherichia coli	The Journal of biological chemistry
18258262	2008-03-21	Mapping the cofilin binding site on yeast G-actin by chemical cross-linking	Journal of molecular biology
17441691	2007-05-15	Structure and function of transmembrane segment XII in osmosensor and osmoprotectant transporter ProP of Escherichia coli	Biochemistry
16042394	2005-08-02	Formation of an antiparallel, intermolecular coiled coil is associated with in vivo dimerization of osmosensor and osmoprotectant transporter ProP in Escherichia coli	Biochemistry

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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