1,4-BIS-MALEIMIDOBUTANE
Product Information
Molecular Formula
C12H12N2O4
Molecular Weight
248.23
Description
1,4-BIS-MALEIMIDOBUTANE is a useful reagent in bioconjugation, protein research, and drug discovery due to its potential to link two sulfhydryl-containing molecules. It's largely employed in constructing various pharmacological agents and formulating new therapeutic strategies for diseases such as cancer.
Synonyms
1,4-BIS(MALEIMIDE)BUTANE; 1,4-BIS-MALEIMIDOBUTANE; 1,4-DI(MALEIMIDO)BUTANE; BMB; N,N'-(TETRAMETHYLENE)DIMALEIMIDE; NSC44747
IUPAC Name
1-[4-(2,5-dioxopyrrol-1-yl)butyl]pyrrole-2,5-dione
SMILES
C1=CC(=O)N(C1=O)CCCCN2C(=O)C=CC2=O
InChI
InChI=1S/C12H12N2O4/c15-9-3-4-10(16)13(9)7-1-2-8-14-11(17)5-6-12(14)18/h3-6H,1-2,7-8H2
InChI Key
WXXSHAKLDCERGU-UHFFFAOYSA-N
Boiling Point
450.3°C at 760mmHg
Melting Point
196-197°C
Purity
99%
Density
1.388g/cm3
Appearance
White to Off-White Powder
Application
A short, sulfhydryl reactive homobifunctional crosslinking reagent.
Storage
<0°C
Safety Information
Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Computed Properties
XLogP3
-0.5
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
5
Exact Mass
248.07970687 g/mol
Monoisotopic Mass
248.07970687 g/mol
Topological Polar Surface Area
74.8Ų
Heavy Atom Count
18
Formal Charge
0
Complexity
399
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-113248900-A | Dynamic bond crosslinking high-filling heat-conducting composite material and preparation method and application thereof | 2021-05-20 |
| KR-102328197-B1 | Nano-liposome delivery carrier composition having KRAS and P53 gene editing function | 2021-03-09 |
| JP-6981522-B1 | Thermosetting resin composition and its use | 2020-12-15 |
| CN-112341644-A | Modified chitosan reinforced self-repairing natural rubber and preparation method thereof | 2020-11-02 |
| KR-20220021430-A | Fusion protein comprising antibody for targeting oncogenic protein or single chain fragment variable (scFv) thereof and cancer cell penetrating peptide and use of the same | 2020-08-13 |
| WO-2022035262-A1 | Antibody targeting intracellular tumor-inducing protein, or fusion protein of single strand variable fragment thereof and cancer-cell-penetrating peptide, and use thereof | 2020-08-13 |
| WO-2022036010-A1 | Green closed loop bio-waste refining process for producing smart active extracts and delivery systems for their application | 2020-08-11 |
| CN-111848963-A | Preparation method of flame-retardant resin capable of being repeatedly processed and thermally cured at high temperature | 2020-07-14 |
| CN-113930047-A | Hot-weldable heat-recoverable epoxy fireproof plate and preparation method thereof | 2020-07-14 |
| WO-2022004872-A1 | Chopped carbon fiber bundle and production method for chopped carbon fiber bundle | 2020-07-03 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 19583260 | 2009-12-10 | Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors | Journal of medicinal chemistry |
