Dithio-bis-maleimidoethane
Product Information
Molecular Formula
C12H12N2O4S2
Molecular Weight
312.36
Description
Dithio-bis-maleimidoethane is a highly necessary and groundbreaking biomedical agent. It is widely used in innovative research efforts on drug delivery and antibody-drug conjugates.
Synonyms
1,1'-(Dithiodi-2,1-ethanediyl)bis-1H-pyrrole-2,5-dione; 1-[2-[[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]dithio]ethyl]-1H-pyrrole-2,5-dione;
DTME
DTME
IUPAC Name
1-[2-[2-(2,5-dioxopyrrol-1-yl)ethyldisulfanyl]ethyl]pyrrole-2,5-dione
SMILES
C1=CC(=O)N(C1=O)CCSSCCN2C(=O)C=CC2=O
InChI
InChI=1S/C12H12N2O4S2/c15-9-1-2-10(16)13(9)5-7-19-20-8-6-14-11(17)3-4-12(14)18/h1-4H,5-8H2
InChI Key
SGVWDRVQIYUSRA-UHFFFAOYSA-N
Boiling Point
518.6±35.0 °C(Predicted)
Melting Point
124°C
Purity
>98.0%(HPLC)(N)
Density
1.511±0.06 g/cm3(Predicted)
Appearance
White Solid
Application
A sulfhydryl reactive homobifunctional crosslinking reagent.
Spacer Arm: 13.3 Angstroms
Spacer Arm: 13.3 Angstroms
Storage
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Safety Information
Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Computed Properties
XLogP3
-0.6
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Rotatable Bond Count
7
Exact Mass
312.02384922 g/mol
Monoisotopic Mass
312.02384922 g/mol
Topological Polar Surface Area
125Ų
Heavy Atom Count
20
Formal Charge
0
Complexity
434
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| JP-6981522-B1 | Thermosetting resin composition and its use | 2020-12-15 |
| KR-20210121422-A | Method for producing polymer crosslinked product in molten state and polymer crosslinked product prepared thereby | 2020-03-30 |
| JP-2021105171-A | Thermosetting hard coat, laminated film, and decorative moldings | 2019-12-26 |
| JP-6904474-B1 | Thermosetting hard coat, laminated film, and decorative moldings | 2019-12-26 |
| WO-2021132631-A1 | Thermally curable hardcoat agent, layered film, and decorated molded object | 2019-12-26 |
| WO-2020196764-A1 | Alkali-soluble polyimide and production method thereof, negative-type photosensitive resin composition, cured film, and production method of pattern cured film | 2019-03-27 |
| JP-6636220-B1 | Liquid curable resin composition, stator coil, rotating electric machine, and method for detecting abnormal overheating of rotating electric machine | 2019-01-15 |
| WO-2020148801-A1 | Curable liquid resin composition, stator coil, dynamo-electric machine and method for detecting occurrence of abnormal overheating of dynamo-electric machine | 2019-01-15 |
| EP-3533844-A1 | Inkjet inks for manufacturing printed circuit boards | 2018-03-02 |
| JP-2019116614-A | Thermosetting hard coating agent, laminated film, and decorated molded body | 2017-12-26 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 18326496 | 2008-05-02 | Cardiolipin controls the osmotic stress response and the subcellular location of transporter ProP in Escherichia coli | The Journal of biological chemistry |
| 18258262 | 2008-03-21 | Mapping the cofilin binding site on yeast G-actin by chemical cross-linking | Journal of molecular biology |
| 17441691 | 2007-05-15 | Structure and function of transmembrane segment XII in osmosensor and osmoprotectant transporter ProP of Escherichia coli | Biochemistry |
| 16042394 | 2005-08-02 | Formation of an antiparallel, intermolecular coiled coil is associated with in vivo dimerization of osmosensor and osmoprotectant transporter ProP in Escherichia coli | Biochemistry |
