N-(2-Hydroxypropyl)-2-methyl-prop-2-enamide

Product Information

Molecular Formula:
C7H13NO2
Molecular Weight:
143.18
Description
N-(2-hydroxypropyl)methacrylamide (HPMA) is a difunctional, hydrolytically stable, hydrophilic monomer, a building blocks of modified and new biomaterials.
Synonyms
N-(2-hydroxypropyl)-2-methylprop-2-enamide
IUPAC Name
N-(2-hydroxypropyl)-2-methylprop-2-enamide
Canonical SMILES
CC(CNC(=O)C(=C)C)O
InChI
InChI=1S/C7H13NO2/c1-5(2)7(10)8-4-6(3)9/h6,9H,1,4H2,2-3H3,(H,8,10)
InChI Key
OKPYIWASQZGASP-UHFFFAOYSA-N
Boiling Point
321.2±34.0 °C (Predicted)
Melting Point
67.92 °C
Purity
98 %
Density
1.002 g/cm3
Appearance
Powder
Storage
Store at 4 degrees celsius
LogP
0.45040

Safety Information

Hazards
Unknown
Precautionary Statement
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word
Warning

Computed Properties

XLogP3
0.3
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
3
Exact Mass
143.094628657 g/mol
Monoisotopic Mass
143.094628657 g/mol
Topological Polar Surface Area
49.3Ų
Heavy Atom Count
10
Formal Charge
0
Complexity
143
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-114133688-A Modified water-based organic siloxane-acrylate hybrid resin and preparation and application thereof 2021-11-29
CN-113786519-A Preparation method of photocuring hydrophilic coating 2021-10-11
CN-113786520-A Preparation method of high-durability hydrophilic coating 2021-10-11
CN-113908345-A Preparation method of super-smooth hydrophilic coating 2021-10-11
CN-113549143-A Anti-tumor polypeptide Bax-BH3, fluorescent polymer nano micelle and preparation method and application thereof 2021-07-21
CN-113416315-A Hyperbranched poly-tertiary amine shale inhibitor 2021-06-22
CN-113416524-A High-temperature-resistant hyperbranched poly-tertiary amine as shale inhibitor 2021-06-22
CN-113350047-A Anion sanitary towel 2021-06-03
CN-113150323-A N- (2-hydroxypropyl) methacrylamide hyaluronic acid hydrogel, preparation method and application 2021-04-09
CN-113278181-A Self-cleaning PETG material and application thereof 2021-01-20

Literatures

PMID Publication Date Title Journal
22795544 2012-10-01 Anti-CD20 multivalent HPMA copolymer-Fab' conjugates for the direct induction of apoptosis Biomaterials
22930486 2012-10-01 Surfaces resistant to fouling from biological fluids: towards bioactive surfaces for real applications Macromolecular bioscience
22793269 2012-08-13 Macromolecular HPMA-based nanoparticles with cholesterol for solid-tumor targeting: detailed study of the inner structure of a highly efficient drug delivery system Biomacromolecules
21893178 2012-05-01 Reducible HPMA-co-oligolysine copolymers for nucleic acid delivery International journal of pharmaceutics
22204981 2012-03-01 Multifunctional pH-disintegrable micellar nanoparticles of asymmetrically functionalized β-cyclodextrin-based star copolymer covalently conjugated with doxorubicin and DOTA-Gd moieties Biomaterials
22144261 2012-02-06 RAFT-derived polymer-drug conjugates: poly(hydroxypropyl methacrylamide) (HPMA)-7-ethyl-10-hydroxycamptothecin (SN-38) conjugates ChemMedChem
22334784 2012-01-01 Synthesis, characterization, and in vivo efficacy evaluation of PGG-docetaxel conjugate for potential cancer chemotherapy International journal of nanomedicine
22400063 2012-01-01 Protease-activated drug development Theranostics
22619558 2012-01-01 Effect of intratumoral administration on biodistribution of 64Cu-labeled nanoshells International journal of nanomedicine
22619725 2012-01-01 Combination drug delivery approaches in metastatic breast cancer Journal of drug delivery
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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