2-Chlorotrityl Chloride
Product Information
Molecular Formula
C19H14Cl2
Molecular Weight
313.22
Description
2-Chlorotrityl Chloride is a widely utilized compound in the field of biochemical synthesis, particularly known for its role as a resin linker in solid-phase peptide synthesis. Its unique structure, featuring a chloromethyl group, enables efficient attachment of amino acids, facilitating the stepwise construction of peptides. The compound's stability under acidic conditions makes it a preferred choice for applications requiring robust performance throughout the synthesis process. Its versatility and reliability contribute to its widespread adoption in various synthetic protocols within research and industrial settings.
Synonyms
2-Chlorotrityl Chloride; 1-Chloro-2-(chlorodiphenylmethyl)benzene; 2-Chlorophenyldiphenylchloromethane; 2-Chlorophenyldiphenylmethyl Chloride; Chloro(2-chlorophenyl)diphenylmethane; Diphenyl-2-chlorophenylmethyl Chloride; o-Chlorotriphenylchloromethane
IUPAC Name
1-chloro-2-[chloro(diphenyl)methyl]benzene
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)Cl
InChI
InChI=1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H
InChI Key
JFLSOKIMYBSASW-UHFFFAOYSA-N
Boiling Point
421.3°C at 760 mmHg
Melting Point
130-135 °C
Purity
> 95%
Density
1.222 g/cm3
Solubility
Soluble in Chloroform, Ethyl Acetate
Appearance
Pale to yellow beads
Storage
Store at 2-8 °C
Safety Information
Hazards
H302-H315-H319-H335
Precautionary Statement
P261-P305+P351+P338
GHS Pictogram
GHS07
Signal Word
Warning
Computed Properties
XLogP3
6.2
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
0
Rotatable Bond Count
3
Exact Mass
312.0472558
Monoisotopic Mass
312.0472558
Topological Polar Surface Area
0
Heavy Atom Count
21
Formal Charge
0
Complexity
298
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-115073550-A | A dipeptide bifunctional small molecule compound for activating enzyme-catalyzed reaction and its application | 2022-07-06 |
| CN-115286692-A | A kind of quaternary ammonium salt modified antibacterial peptidomimetic structure and preparation method and application thereof | 2022-06-30 |
| CN-115058383-A | Three-dimensional reprogrammed USCs, their culture method and their application in anti-diabetic and hypotensive | 2022-06-20 |
| CN-114989252-A | A kind of novel photosensitizer and its preparation method and application | 2022-06-15 |
| CN-115093422-A | A novel photosensitizer based on metabolic labeling strategy and its preparation method and application | 2022-06-15 |
| CN-114796240-A | A kind of self-assembled chiral short peptide drug and its preparation method and application | 2022-06-08 |
| CN-114805487-A | A kind of polypeptide compound and its application | 2022-06-07 |
| CN-114939389-A | A kind of mixing device for clotrimazole production | 2022-06-06 |
| CN-114957388-A | A kind of short peptide fluorescent probe and its preparation method and application | 2022-06-02 |
| CN-115010786-A | A GSH-hypoxic microenvironment dual-responsive self-assembled fluorescent probe and its preparation method and application | 2022-06-02 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22212592 | 2012-09-01 | Comparative syntheses of peptides and peptide thioesters derived from mouse and human prion proteins | Amino acids |
| 22786744 | 2012-09-01 | Synthesis, biological activity and conformational analysis of head-to-tail cyclic analogues of LL37 and histatin 5 | Journal of peptide science : an official publication of the European Peptide Society |
| 21922266 | 2012-07-01 | Variation of the intercalating proline in artificial peptides mimicking the DNA binding and bending IHF protein | Amino acids |
| 21882170 | 2012-01-01 | Use of Oxyma as pH modulatory agent to be used in the prevention of base-driven side reactions and its effect on 2-chlorotrityl chloride resin | Biopolymers |
| 22685432 | 2012-01-01 | Triarylmethanes, a new class of cx50 inhibitors | Frontiers in pharmacology |
| 21714097 | 2011-09-05 | Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 | ChemMedChem |
| 21608132 | 2011-08-01 | Discovery of adamantyl heterocyclic ketones as potent 11β-hydroxysteroid dehydrogenase type 1 inhibitors | ChemMedChem |
| 21452877 | 2011-05-06 | Giant macrolactams based on β-sheet peptides | The Journal of organic chemistry |
| 20872260 | 2011-05-01 | Microwave-assisted solid-phase peptide synthesis of the 60-110 domain of human pleiotrophin on 2-chlorotrityl resin | Amino acids |
| 20564042 | 2011-01-01 | Synthesis of MUC1 glycopeptide thioesters and ligation via direct aminolysis | Biopolymers |
