2-Chlorotrityl Chloride

Product Information

Molecular Formula
C19H14Cl2
Molecular Weight
313.22
Description
Extremely acid labile resin for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Cleavage can be effected by using AcOH/TFE/DCM or 0.5% TFA.
Synonyms
2-Chlorotrityl Chloride; 1-Chloro-2-(chlorodiphenylmethyl)benzene; 2-Chlorophenyldiphenylchloromethane; 2-Chlorophenyldiphenylmethyl Chloride; Chloro(2-chlorophenyl)diphenylmethane; Diphenyl-2-chlorophenylmethyl Chloride; o-Chlorotriphenylchloromethane
IUPAC Name
1-chloro-2-[chloro(diphenyl)methyl]benzene
Canonical SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)Cl
InChI
InChI=1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H
InChI Key
JFLSOKIMYBSASW-UHFFFAOYSA-N
Boiling Point
421.3°C at 760 mmHg
Melting Point
130-135 °C
Purity
> 95%
Density
1.222 g/cm3
Solubility
Soluble in Chloroform, Ethyl Acetate
Appearance
Pale to yellow beads
Storage
Store at 2-8 °C

Safety Information

Hazards
H302-H315-H319-H335
Precautionary Statement
P261-P305+P351+P338
GHS Pictogram
GHS07
Signal Word
Warning

Computed Properties

XLogP3
6.2
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
0
Rotatable Bond Count
3
Exact Mass
312.0472558
Monoisotopic Mass
312.0472558
Topological Polar Surface Area
0
Heavy Atom Count
21
Formal Charge
0
Complexity
298
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-115073550-A A dipeptide bifunctional small molecule compound for activating enzyme-catalyzed reaction and its application 2022-07-06
CN-115286692-A A kind of quaternary ammonium salt modified antibacterial peptidomimetic structure and preparation method and application thereof 2022-06-30
CN-115058383-A Three-dimensional reprogrammed USCs, their culture method and their application in anti-diabetic and hypotensive 2022-06-20
CN-114989252-A A kind of novel photosensitizer and its preparation method and application 2022-06-15
CN-115093422-A A novel photosensitizer based on metabolic labeling strategy and its preparation method and application 2022-06-15
CN-114796240-A A kind of self-assembled chiral short peptide drug and its preparation method and application 2022-06-08
CN-114805487-A A kind of polypeptide compound and its application 2022-06-07
CN-114939389-A A kind of mixing device for clotrimazole production 2022-06-06
CN-114957388-A A kind of short peptide fluorescent probe and its preparation method and application 2022-06-02
CN-115010786-A A GSH-hypoxic microenvironment dual-responsive self-assembled fluorescent probe and its preparation method and application 2022-06-02

Literatures

PMID Publication Date Title Journal
22212592 2012-09-01 Comparative syntheses of peptides and peptide thioesters derived from mouse and human prion proteins Amino acids
22786744 2012-09-01 Synthesis, biological activity and conformational analysis of head-to-tail cyclic analogues of LL37 and histatin 5 Journal of peptide science : an official publication of the European Peptide Society
21922266 2012-07-01 Variation of the intercalating proline in artificial peptides mimicking the DNA binding and bending IHF protein Amino acids
21882170 2012-01-01 Use of Oxyma as pH modulatory agent to be used in the prevention of base-driven side reactions and its effect on 2-chlorotrityl chloride resin Biopolymers
22685432 2012-01-01 Triarylmethanes, a new class of cx50 inhibitors Frontiers in pharmacology
21714097 2011-09-05 Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 ChemMedChem
21608132 2011-08-01 Discovery of adamantyl heterocyclic ketones as potent 11β-hydroxysteroid dehydrogenase type 1 inhibitors ChemMedChem
21452877 2011-05-06 Giant macrolactams based on β-sheet peptides The Journal of organic chemistry
20872260 2011-05-01 Microwave-assisted solid-phase peptide synthesis of the 60-110 domain of human pleiotrophin on 2-chlorotrityl resin Amino acids
20564042 2011-01-01 Synthesis of MUC1 glycopeptide thioesters and ligation via direct aminolysis Biopolymers
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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