Knorr-2-Chlorotrityl Resin
Product Information
Molecular Formula
C19H14Cl2
Molecular Weight
312.0472558
Description
Knorr-2-Chlorotrityl Resin is a robust tool in solid-phase peptide synthesis, offering researchers a stable platform for anchoring peptide chains. This resin is renowned for its ability to facilitate the efficient synthesis of complex peptides due to its unique chlorotrityl functional group. Its chemical structure allows for the selective cleavage of peptide chains under mild acidic conditions, preserving the integrity of sensitive sequences. Widely utilized in biochemical laboratories, Knorr-2-Chlorotrityl Resin supports diverse applications in peptide research and development.
Synonyms
2-Chlorotrityl chloride; (Chloro(2-chlorophenyl)methylene)dibenzene; 2-Chlorotrityl Chloride Resin; 2-Chlorophenyldiphenylmethyl Chloride; 2-Chlorotritylchloride; (2-Chlorophenyl)diphenylmethyl Chloride; 1-Chloro-2-(chlorodiphenylmethyl)benzene; Chlorotrityl chloride; 1-chloro-2-[chloro(diphenyl)methyl]benzene; 2-chlorotrityl resin; o-Chlorotriphenylchloromethane; Chloro(2-chlorophenyl)diphenylmethane; 2-Chloro-tritylchloride; 2-CHLOROPHENYLDIPHENYLCHLOROMETHANE; benzene, 1-chloro-2-(chlorodiphenylmethyl)-
IUPAC Name
1-chloro-2-[chloro(diphenyl)methyl]benzene
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)Cl
InChI
InChI=1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H
InChI Key
JFLSOKIMYBSASW-UHFFFAOYSA-N
Purity
100-200 mesh,1% DVB,0.4-3.0mmol/g
Solubility
None
Safety Information
Hazards
H302-H315-H319-H335
Precautionary Statement
P261-P305+P351+P338
GHS Pictogram
GHS07
Signal Word
Warning
Computed Properties
XLogP3
6.2
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
0
Rotatable Bond Count
3
Exact Mass
312.0472558
Monoisotopic Mass
312.0472558
Topological Polar Surface Area
0
Heavy Atom Count
21
Formal Charge
0
Complexity
298
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-115073550-A | A dipeptide bifunctional small molecule compound for activating enzyme-catalyzed reaction and its application | 2022-07-06 |
| CN-115286692-A | A kind of quaternary ammonium salt modified antibacterial peptidomimetic structure and preparation method and application thereof | 2022-06-30 |
| CN-115058383-A | Three-dimensional reprogrammed USCs, their culture method and their application in anti-diabetic and hypotensive | 2022-06-20 |
| CN-114989252-A | A kind of novel photosensitizer and its preparation method and application | 2022-06-15 |
| CN-115093422-A | A novel photosensitizer based on metabolic labeling strategy and its preparation method and application | 2022-06-15 |
| CN-114796240-A | A kind of self-assembled chiral short peptide drug and its preparation method and application | 2022-06-08 |
| CN-114805487-A | A kind of polypeptide compound and its application | 2022-06-07 |
| CN-114939389-A | A kind of mixing device for clotrimazole production | 2022-06-06 |
| CN-114957388-A | A kind of short peptide fluorescent probe and its preparation method and application | 2022-06-02 |
| CN-115010786-A | A GSH-hypoxic microenvironment dual-responsive self-assembled fluorescent probe and its preparation method and application | 2022-06-02 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22212592 | 2012-09-01 | Comparative syntheses of peptides and peptide thioesters derived from mouse and human prion proteins | Amino acids |
| 22786744 | 2012-09-01 | Synthesis, biological activity and conformational analysis of head-to-tail cyclic analogues of LL37 and histatin 5 | Journal of peptide science : an official publication of the European Peptide Society |
| 21922266 | 2012-07-01 | Variation of the intercalating proline in artificial peptides mimicking the DNA binding and bending IHF protein | Amino acids |
| 21882170 | 2012-01-01 | Use of Oxyma as pH modulatory agent to be used in the prevention of base-driven side reactions and its effect on 2-chlorotrityl chloride resin | Biopolymers |
| 22685432 | 2012-01-01 | Triarylmethanes, a new class of cx50 inhibitors | Frontiers in pharmacology |
| 21714097 | 2011-09-05 | Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 | ChemMedChem |
| 21608132 | 2011-08-01 | Discovery of adamantyl heterocyclic ketones as potent 11β-hydroxysteroid dehydrogenase type 1 inhibitors | ChemMedChem |
| 21452877 | 2011-05-06 | Giant macrolactams based on β-sheet peptides | The Journal of organic chemistry |
| 20872260 | 2011-05-01 | Microwave-assisted solid-phase peptide synthesis of the 60-110 domain of human pleiotrophin on 2-chlorotrityl resin | Amino acids |
| 20564042 | 2011-01-01 | Synthesis of MUC1 glycopeptide thioesters and ligation via direct aminolysis | Biopolymers |
