Amino-PEG3-propionic acid

Product Information

Molecular Formula:
C9H19NO5
Molecular Weight:
221.25
Description
Amino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
3-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)propanoic acid; H2N-PEG3-CH2CH2COOH
IUPAC Name
3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]propanoic acid
Canonical SMILES
C(COCCOCCOCCN)C(=O)O
InChI
InChI=1S/C9H19NO5/c10-2-4-14-6-8-15-7-5-13-3-1-9(11)12/h1-8,10H2,(H,11,12)
InChI Key
XUQZKSCQPMNDEY-UHFFFAOYSA-N
Boiling Point
372.1±32.0 °C at 760 mmHg
Purity
≥ 97.0 %
Density
1.1±0.1 g/cm3
Solubility
10 mm in DMSO
Appearance
White powder
Storage
Store at -20 °C, keep in dry and avoid sunlight.
LogP
0.16990

Safety Information

Hazards
H302-H315-H319-H335
Precautionary Statement
P261-P305+P351+P338
GHS Pictogram
GHS07
Signal Word
Warning

Computed Properties

XLogP3
-3.9
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Rotatable Bond Count
11
Exact Mass
221.12632271
Monoisotopic Mass
221.12632271
Topological Polar Surface Area
91
Heavy Atom Count
15
Formal Charge
0
Complexity
153
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
WO-2022198319-A1 Use of a cold fgfr3-targeting molecule and a fgfr3 targeting radioimmunoconjugate for treating cancer 2021-03-23
WO-2022192597-A2 Affinity agents 2021-03-10
WO-2022180145-A2 Inhibitors of il-11 or il-11ra for use in the treatment of abnormal uterine bleeding 2021-02-26
WO-2022180172-A1 Inhibitors of il-11 or il-11ra for use in the treatment of abnormal uterine bleeding 2021-02-26
WO-2022155385-A1 Methods and compositions for visualizing a ureter in a surgical procedure 2021-01-14
EP-4011904-A1 Masp inhibitory compounds and uses thereof 2020-12-14
WO-2022120177-A1 Nerve targeting peptides and methods of use 2020-12-04
WO-2022112400-A1 Poly-diacetylene sensors and methods for characterizing samples 2020-11-26
WO-2022096394-A1 Masp inhibitory compounds and uses thereof 2020-11-04
WO-2022052823-A1 Small-molecule conjugate and use thereof 2020-09-11
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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