5-Norbornene-2-endo-acetic acid
Product Information
Molecular Formula
C9H12O2
Molecular Weight
152.19
Description
Carboxylic acid functionalized norbornene. Carboxylic acid can be used to modify amine containing compounds such as lysine residues on proteins/peptides via standard peptide coupling methods. Norbornene has been shown to react with 1,2,4,5-tetrazines in an inverse electron demand Diels-Alder cycloaddition reaction, which is a bioorthogonal click chemistry reaction demonstrated to be useful in biological imaging applications.
Synonyms
2-(2-bicyclo[2.2.1]hept-5-enyl)acetic acid
IUPAC Name
2-(2-bicyclo[2.2.1]hept-5-enyl)acetic acid
SMILES
C1C2CC(C1C=C2)CC(=O)O
InChI
InChI=1S/C9H12O2/c10-9(11)5-8-4-6-1-2-7(8)3-6/h1-2,6-8H,3-5H2,(H,10,11)
InChI Key
HRVGJQMCNYJEHM-UHFFFAOYSA-N
Flash Point
Not applicable
Density
1.124 g/mL at 25 °C
Refractive Index
1.495
LogP
1.67330
Safety Information
Hazards
H302 - H412
Precautionary Statement
P273 - P301 + P312 + P330
Signal Word
Warning
Computed Properties
XLogP3
1.6
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
2
Exact Mass
152.083729621 g/mol
Monoisotopic Mass
152.083729621 g/mol
Topological Polar Surface Area
37.3Ų
Heavy Atom Count
11
Formal Charge
0
Complexity
208
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
3
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| KR-20220007488-A | NIR responsive ECM-based hydrogel, preparation method thereof, and composition for filler treatment using the same | 2020-07-10 |
| TW-202138406-A | Cyclic olefin copolymer, cycloolefinic resin composition, cross-linked product thereof and molded article thereof | 2020-01-24 |
| US-2021149300-A1 | Resist composition and patterning process | 2019-11-20 |
| US-2021116807-A1 | Photosensitive compositions and applications thereof | 2019-10-17 |
| WO-2021076131-A1 | Photosensitive compositions and applications thereof | 2019-10-17 |
| US-2021080828-A1 | Resist composition and patterning process | 2019-09-13 |
| US-2021048747-A1 | Chemically amplified resist composition and patterning process | 2019-08-14 |
| US-2021033970-A1 | Resist composition and patterning process | 2019-08-02 |
| JP-2021014568-A | Compositions containing colorants | 2019-07-10 |
| WO-2021005997-A1 | Composition containing coloring agent | 2019-07-10 |
