6,6'-di-tert-butyl-4,4'-butylidenedi-m-cresol
Product Information
Molecular Formula
C26H38O2
Molecular Weight
382.58
Description
6,6'-di-tert-butyl-4,4'-butylidenedi-m-cresol is a remarkable chemical compound that finds extensive application within the biomedical domain. Recognized for its exceptional antioxidant properties, this compound is widely utilized in the development of pharmaceuticals and personal care commodities. Its profound ability to combat oxidative stress safeguards against the deterioration of therapeutic agents and active components. Renowned for its contribution towards enhancing the stability and prolonging the shelf life of a multitude of medications and skincare products, it remains an invaluable ingredient in these formulations.
Synonyms
4,4'-BUTYLIDENE-BIS-(6-BUTYL-3-METHYLPHENOL); 4,4'-BUTYLIDENEBIS(6-T-BUTYL-3-METHYLPHENOL); 4,4'-BUTYLIDENEBIS(6-TERT-BUTYL-3-METHYLPHENOL); 4,4'-BUTYLIDENEBIS(6-TERT-BUTYL-M-CRESOL); SANTOWHITE(R) POWDER; 1,1-bis(2-methyl-4-hydroxy-5-tert-butylphenyl)butane;
IUPAC Name
2-tert-butyl-4-[1-(5-tert-butyl-4-hydroxy-2-methylphenyl)butyl]-5-methylphenol
SMILES
CCCC(C1=CC(=C(C=C1C)O)C(C)(C)C)C2=CC(=C(C=C2C)O)C(C)(C)C
InChI
InChI=1S/C26H38O2/c1-10-11-18(19-14-21(25(4,5)6)23(27)12-16(19)2)20-15-22(26(7,8)9)24(28)13-17(20)3/h12-15,18,27-28H,10-11H2,1-9H3
InChI Key
PFANXOISJYKQRP-UHFFFAOYSA-N
Boiling Point
475.5°C at 760 mmHg
Melting Point
211°C
Purity
95%
Density
1.001 g/cm3
Appearance
White to Off white powder
Application
Used as antioxidant for natural and synthetic rubber and latex.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Safety Information
Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Computed Properties
XLogP3
8.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
6
Exact Mass
382.287180451 g/mol
Monoisotopic Mass
382.287180451 g/mol
Topological Polar Surface Area
40.5Ų
Heavy Atom Count
28
Formal Charge
0
Complexity
444
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| JP-2022036178-A | Performance evaluation method and manufacturing control method of foamable laminate | 2021-12-28 |
| CN-114085528-A | Weather-proof heat-resistant PPO-PPS plastic alloy material and preparation method and application thereof | 2021-12-22 |
| JP-2022040133-A | A photosensitive coloring composition for a color filter for a solid-state image sensor, a color filter, and a solid-state image sensor using the same. | 2021-12-15 |
| JP-2022043096-A | Resin composition, method for manufacturing cured relief pattern, and semiconductor device | 2021-12-01 |
| JP-2022009110-A | Delamination resin film, interlayer insulation resin film with adhesive auxiliary layer, and printed wiring board | 2021-10-13 |
| CN-113640452-A | Detection method of body-consolidating and life-prolonging pills | 2021-09-23 |
| JP-2022008395-A | Red coloring composition for organic EL display device, color filter for organic EL display device and organic EL display device | 2021-09-14 |
| KR-102357010-B1 | Manufacturing manufacturing method of metal furniture for interior with enhanced discoloration resistance | 2021-06-21 |
| KR-102313487-B1 | Color rubber for wireless charger pads with anti-discoloration effects in natural conditions | 2021-05-31 |
| JP-6998483-B1 | Ink composition | 2021-05-12 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 20045927 | 2010-01-01 | Increase in in utero exposure to a migrant, 4,4'-butylidenebis(6-t-butyl-m-cresol), from nitrile-butadiene rubber gloves on brain aromatase activity in male rats | Biological & pharmaceutical bulletin |
| 19043201 | 2008-12-01 | The effects of in utero exposure to a migrant, 4,4'-butylidenebis(6-t-butyl-m-cresol), from nitrile-butadiene rubber gloves on monoamine neurotransmitter in rats | Biological & pharmaceutical bulletin |
| 17924095 | 2008-05-01 | Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4'-butylidenebis(2-tert-butyl-5-methylphenol) and 3-(dibutylamino)phenol, based on the OECD draft protocols | Archives of toxicology |
| 18310895 | 2008-03-01 | Endocrine disruptive effects of chemicals eluted from nitrile-butadiene rubber gloves using reporter gene assay systems | Biological & pharmaceutical bulletin |
| 17941731 | 2007-11-01 | Occurrence and estrogenicity of phenolics in paper-recycling process water: pollutants originating from thermal paper in waste paper | Environmental toxicology and chemistry |
| 16231125 | 2006-04-01 | Male reproductive toxicity of four bisphenol antioxidants in mice and rats and their estrogenic effect | Archives of toxicology |
| 16278858 | 2006-03-01 | Antioxidant inhibition of poly(carbonate urethane) in vivo biodegradation | Journal of biomedical materials research. Part A |
| 15227669 | 2004-08-01 | Oxidative mechanisms of poly(carbonate urethane) and poly(ether urethane) biodegradation: in vivo and in vitro correlations | Journal of biomedical materials research. Part A |
| 12846157 | 2003-04-01 | [Identification of migrants from nitrile-butadiene rubber gloves] | Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan |
