Amifampridine
Product Information
Molecular Formula
C5H7N3
Molecular Weight
109.13
Description
Amifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases. It is used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor.
Synonyms
pyridine-3,4-diamine
IUPAC Name
pyridine-3,4-diamine
SMILES
C1=CN=CC(=C1N)N
InChI
InChI=1S/C5H7N3/c6-4-1-2-8-3-5(4)7/h1-3H,7H2,(H2,6,8)
InChI Key
OYTKINVCDFNREN-UHFFFAOYSA-N
Boiling Point
369.3 °C at 760 mmHg
Purity
> 98 %
Density
1.251 g/cm3
Solubility
12.2 [ug/mL] (The mean of the results at pH 7.4)
Application
Neuromuscular Agents
LogP
1.40840
Related CAS
446254-47-3 (Phosphate)
Safety Information
Hazards
H300+H330-H311-H315-H319-H335
Precautionary Statement
P260, P261, P264, P270, P271, P280, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501
Safety Class
6.1
GHS Pictogram
GHS06
Signal Word
Danger
Computed Properties
XLogP3
-0.5
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
0
Exact Mass
109.063997236
Monoisotopic Mass
109.063997236
Topological Polar Surface Area
64.9
Heavy Atom Count
8
Formal Charge
0
Complexity
74.1
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-115260442-A | A kind of fast self-healing thermoplastic polyurethane elastomer material and preparation method thereof | 2022-08-28 |
| CN-115287065-A | A kind of preparation method and application of nitrogen and phosphorus co-doped carbon dots | 2022-08-09 |
| CN-115184486-A | A kind of method for detecting diaminopyridine phosphate related substances by high performance liquid chromatography | 2022-06-27 |
| CN-114712321-A | Diaminopyridine phosphate sustained-release tablet and preparation method thereof | 2022-04-22 |
| CN-114682104-A | A kind of perovskite type conductive ceramic film and its preparation method and application | 2022-03-30 |
| CN-114517051-A | Aqueous polyurethane-urea dispersion, preparation method and application thereof | 2022-03-02 |
| CN-114426981-A | African swine fever virus antigen protein recombinant expression vector, recombinant plant lactic acid bacteria and preparation method and application thereof | 2022-02-21 |
| CN-114426981-B | African swine fever virus antigen protein recombinant expression vector, recombinant plant lactic acid bacteria and its preparation method and application | 2022-02-21 |
| CN-114371158-A | Preparation method of hydrogel kit for monitoring degradation of organophosphorus pesticide | 2022-01-29 |
| CN-114349758-A | Compound with pyridine imidazole as parent nucleus and preparation method and application thereof | 2022-01-21 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 28641995 | 2017-07-01 | Acetylator Status Impacts Amifampridine Phosphate (Firdapse™) Pharmacokinetics and Exposure to a Greater Extent Than Renal Function | Clinical therapeutics |
| 26852139 | 2016-05-01 | Amifampridine phosphate (Firdapse(®)) is effective and safe in a phase 3 clinical trial in LEMS | Muscle & nerve |
| 26101174 | 2015-07-01 | Effects of Food Intake on the Relative Bioavailability of Amifampridine Phosphate Salt in Healthy Adults | Clinical therapeutics |
| 25015919 | 2014-08-15 | Complete reversal of Lambert-Eaton myasthenic syndrome synaptic impairment by the combined use of a K+ channel blocker and a Ca2+ channel agonist | The Journal of physiology |
| 22922120 | 2012-12-06 | Ectopic uterine tissue as a chronic pain generator | Neuroscience |
| 22841859 | 2012-11-01 | Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations | Neurochemistry international |
| 22742743 | 2012-07-13 | Mutations in DPAGT1 cause a limb-girdle congenital myasthenic syndrome with tubular aggregates | American journal of human genetics |
| 22805230 | 2012-07-01 | The use of aminopyridines in neurological disorders | Clinical neuropharmacology |
| 22497693 | 2012-05-01 | The safety profile of dalfampridine extended release in multiple sclerosis clinical trials | Clinical therapeutics |
| 22409941 | 2012-04-01 | 3,4-Diaminopyridine improves neuromuscular transmission in a MuSK antibody-induced mouse model of myasthenia gravis | Journal of neuroimmunology |
