CIS-1,4-CYCLOHEXANEDIAMINE
Product Information
Molecular Formula
C6H14N2
Molecular Weight
114.19
Description
CIS-1,4-CYCLOHEXANEDIAMINE is a compound of immense importance in the biomedical sector and assumes a significant position owing to its multifarious applications. With its pivotal role in the formulation of therapeutic remedies targeting afflictions encompassing cancer, cardiovascular ailments, and neurological disorders, it exemplifies its indispensability. Furthermore, its inherent versatility facilitates the amalgamation of diverse pharmaceutical compounds, thus rendering it an indispensable element in the realm of biomedical exploration.
Synonyms
CIS-1,4-CYCLOHEXANEDIAMINE; CIS-1,4-DIAMINOCYCLOHEXANE; CI(S)-CYCLOHEXANE-1,4-DIAMINE; 1,4-Cyclohexanediamine, cis-
IUPAC Name
cyclohexane-1,4-diamine
SMILES
C1CC(CCC1N)N
InChI
InChI=1S/C6H14N2/c7-5-1-2-6(8)4-3-5/h5-6H,1-4,7-8H2
InChI Key
VKIRRGRTJUUZHS-UHFFFAOYSA-N
Boiling Point
199.4°C at 760mmHg
Flash Point
80 °C
Purity
>98.0%(T)
Density
0.97
Appearance
Colorless to Light yellow to Light orange clear liquid
Safety Information
Hazards
H314:
Causes severe skin burns and eye damage.
Causes severe skin burns and eye damage.
Precautionary Statement
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331:
IF SWALLOWED:
Rinse mouth.
Do NOT induce vomiting.
P303+P361+P353:
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. [As modified by IV ATP].
Rinse skin with water/shower.
P304+P340+P310:
IF INHALED:
Remove person to fresh air and keep comfortable for breathing.
Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338+P310:
IF IN EYES:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do. Continue rinsing.
Immediately call a POISON CENTER or doctor/physician.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331:
IF SWALLOWED:
Rinse mouth.
Do NOT induce vomiting.
P303+P361+P353:
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. [As modified by IV ATP].
Rinse skin with water/shower.
P304+P340+P310:
IF INHALED:
Remove person to fresh air and keep comfortable for breathing.
Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338+P310:
IF IN EYES:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do. Continue rinsing.
Immediately call a POISON CENTER or doctor/physician.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Computed Properties
XLogP3
-0.3
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
0
Exact Mass
114.115698455 g/mol
Monoisotopic Mass
114.115698455 g/mol
Topological Polar Surface Area
52Ų
Heavy Atom Count
8
Formal Charge
0
Complexity
54.9
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114181373-A | Preparation process of comfortable spandex and prepared spandex | 2022-01-29 |
| CN-114028958-A | Preparation method for improving desalination rate of reverse osmosis membrane | 2021-12-17 |
| CN-114058008-A | Process for preparing semi-aromatic polyamides end-capped with monocarboxylic acids, semi-aromatic polyamides and molding compositions | 2021-12-13 |
| CN-114058009-A | Process for preparing semi-aromatic polyamides with reduced loss of diamine monomer, semi-aromatic polyamides and molding compositions | 2021-12-13 |
| CN-114058010-A | Process for preparing low-energy semiaromatic polyamides, semiaromatic polyamides and moulding compositions | 2021-12-13 |
| CN-114133559-A | Process for preparing semiaromatic polyamides with reduced salt formation cycle, semiaromatic polyamides and moulding compositions | 2021-12-13 |
| CN-114015054-A | Phthalic anhydride organic silicon dihydric alcohol, preparation method and thermoplastic phenyl silicon polyurethane adhesive | 2021-12-09 |
| CN-114015405-A | High-performance polyurethane pressure-sensitive adhesive and preparation method and application thereof | 2021-12-07 |
| CN-114053876-A | Preparation method of anti-pollution reverse osmosis membrane | 2021-12-02 |
| CN-114146566-A | Preparation method of high-performance polyolefin substrate reverse osmosis membrane, reverse osmosis membrane and application | 2021-12-02 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 24973920 | 2014-07-01 | Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition | Nature medicine |
| 22121674 | 2011-07-01 | Preparation and characterization of nanoporous thin films from fully aliphatic polyimides | Journal of nanoscience and nanotechnology |
| 21333275 | 2011-04-01 | Microwave-induced facile synthesis of water-soluble fluorogenic alginic acid derivatives | Carbohydrate research |
| 19782655 | 2010-02-15 | Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring Pt II chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand | Biochemical pharmacology |
| 20066228 | 2010-01-21 | Catalytic performance of the high and low temperature polymorphs of (C6N2H16)0.5[(VO)(HAsO4)F]: structural, thermal, spectroscopic and magnetic studies | Dalton transactions (Cambridge, England : 2003) |
| 19500978 | 2009-08-01 | Potent agonists of the Hedgehog signaling pathway | Bioorganic & medicinal chemistry letters |
| 19034934 | 2009-01-01 | Self-assembly of two-component gels: stoichiometric control and component selection | Chemistry (Weinheim an der Bergstrasse, Germany) |
| 18644730 | 2008-08-15 | Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: effects of the phenyl substituent and the linker orientation | Bioorganic & medicinal chemistry |
| 18299969 | 2008-06-01 | Trans-cyclohexanediamines prevent thermal inactivation of protein: role of hydrophobic and electrostatic interactions | The protein journal |
| 18454143 | 2008-06-01 | Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility | Nature chemical biology |
