Di-tert-butyl N,N-diisopropylphosphoramidite
Product Information
Molecular Formula
C14H32NO2P
Molecular Weight
277.38
Description
Di-tert-butyl N,N-diisopropylphosphoramidite is a general reagent to introduce tert-butyl-protected phosphate groups. It is commonly used in phosphorylation of biomolecules. It can also be used in the synthesis of phosphoramidate-linked glycoconjugates.
Synonyms
DI-T-BUTYL N,N-DIISOPROPYLPHOSPHORAMIDITE; DI-TERT-BUTYL DIISOPROPYLPHOSPHORAMIDITE; DI-TERT-BUTYL-N,N-DIISOPROPYLPHOSPHORAMIDITE; DI-TERT-BUTYL-N,N-DIISOPROPYLPHOSPHOROAMIDITE; N,N-Bis(1-methylethyl)phosphoramidous Acid Bis(1,1-dimethylethyl)ester
IUPAC Name
N-[bis[(2-methylpropan-2-yl)oxy]phosphanyl]-N-propan-2-ylpropan-2-amine
SMILES
CC(C)N(C(C)C)P(OC(C)(C)C)OC(C)(C)C
InChI
InChI=1S/C14H32NO2P/c1-11(2)15(12(3)4)18(16-13(5,6)7)17-14(8,9)10/h11-12H,1-10H3
InChI Key
YGFLCNPXEPDANQ-UHFFFAOYSA-N
Boiling Point
85-90°C0.2 mm Hg(lit.),252.2°C at 760 mmHg
Melting Point
85-90°C 0.2 mm Hg(lit.)
Flash Point
235.4 °F - closed cup
Purity
95%
Density
0.879
Appearance
Clear Colourless Liquid
Application
A phosphinane derivative with immunomodulating activity.
Storage
-20°C
Refractive Index
n20/D 1.444 (lit.)
Safety Information
Hazards
H315 - H319 - H335
Precautionary Statement
P302 + P352 - P305 + P351 + P338
Computed Properties
XLogP3
3.8
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
7
Exact Mass
277.21706626 g/mol
Monoisotopic Mass
277.21706626 g/mol
Topological Polar Surface Area
21.7Ų
Heavy Atom Count
18
Formal Charge
0
Complexity
217
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022006386-A1 | Alkyne quinazoline derivatives as inhibitors of erbb2 | 2020-07-02 |
| US-2022009903-A1 | Anti-viral compounds | 2020-06-10 |
| WO-2021252491-A1 | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections | 2020-06-10 |
| JP-2021167308-A | STING working compound | 2020-04-10 |
| JP-6912016-B1 | STING working compound | 2020-04-10 |
| CA-3140164-A1 | Compounds and methods for the treatment of covid-19 | 2020-04-05 |
| KR-20210151949-A | Compounds and methods for the treatment of COVID-19 | 2020-04-05 |
| US-2022017548-A1 | Compounds and Methods for the Treatment of COVID-19 | 2020-04-05 |
| WO-2021185710-A1 | Process for producing polyether carbonate polyols | 2020-03-17 |
| WO-2021180567-A1 | Process for preparing polyether carbonate polyols | 2020-03-10 |
