Di-tert-butyl N,N-diisopropylphosphoramidite

Inquiry

Molecular Formula:

C14H32NO2P

Molecular Weight:

277.38

CAS Number:

137348-86-8

Catalog Number:

137348-86-8

Product Information

Molecular Formula:

C14H32NO2P

Molecular Weight:

277.38

Description

Di-tert-butyl N,N-diisopropylphosphoramidite is a general reagent to introduce tert-butyl-protected phosphate groups. It is commonly used in phosphorylation of biomolecules. It can also be used in the synthesis of phosphoramidate-linked glycoconjugates.

Synonyms

DI-T-BUTYL N,N-DIISOPROPYLPHOSPHORAMIDITE; DI-TERT-BUTYL DIISOPROPYLPHOSPHORAMIDITE; DI-TERT-BUTYL-N,N-DIISOPROPYLPHOSPHORAMIDITE; DI-TERT-BUTYL-N,N-DIISOPROPYLPHOSPHOROAMIDITE; N,N-Bis(1-methylethyl)phosphoramidous Acid Bis(1,1-dimethylethyl)ester

IUPAC Name

N-[bis[(2-methylpropan-2-yl)oxy]phosphanyl]-N-propan-2-ylpropan-2-amine

Canonical SMILES

CC(C)N(C(C)C)P(OC(C)(C)C)OC(C)(C)C

InChI

InChI=1S/C14H32NO2P/c1-11(2)15(12(3)4)18(16-13(5,6)7)17-14(8,9)10/h11-12H,1-10H3

InChI Key

YGFLCNPXEPDANQ-UHFFFAOYSA-N

Boiling Point

85-90°C0.2 mm Hg(lit.),252.2°C at 760 mmHg

Melting Point

85-90°C 0.2 mm Hg(lit.)

Flash Point

235.4 °F - closed cup

Purity

95%

Density

0.879

Appearance

Clear Colourless Liquid

Application

A phosphinane derivative with immunomodulating activity.

Storage

-20°C

Refractive Index

n20/D 1.444 (lit.)

Safety Information

Hazards

H315 - H319 - H335

Precautionary Statement

P302 + P352 - P305 + P351 + P338

Computed Properties

XLogP3

3.8

Hydrogen Bond Donor Count

Hydrogen Bond Acceptor Count

Rotatable Bond Count

Exact Mass

277.21706626 g/mol

Monoisotopic Mass

277.21706626 g/mol

Topological Polar Surface Area

21.7Å²

Heavy Atom Count

Formal Charge

Complexity

217

Isotope Atom Count

Defined Atom Stereocenter Count

Undefined Atom Stereocenter Count

Defined Bond Stereocenter Count

Undefined Bond Stereocenter Count

Covalently-Bonded Unit Count

Compound Is Canonicalized

Yes

Patents

Publication Number	Title	Priority Date
WO-2022006386-A1	Alkyne quinazoline derivatives as inhibitors of erbb2	2020-07-02
US-2022009903-A1	Anti-viral compounds	2020-06-10
WO-2021252491-A1	Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections	2020-06-10
JP-2021167308-A	STING working compound	2020-04-10
JP-6912016-B1	STING working compound	2020-04-10
CA-3140164-A1	Compounds and methods for the treatment of covid-19	2020-04-05
KR-20210151949-A	Compounds and methods for the treatment of COVID-19	2020-04-05
US-2022017548-A1	Compounds and Methods for the Treatment of COVID-19	2020-04-05
WO-2021185710-A1	Process for producing polyether carbonate polyols	2020-03-17
WO-2021180567-A1	Process for preparing polyether carbonate polyols	2020-03-10

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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