Dicyclohexyl(3-isopropoxy-2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphine

C36H55OP

534.80

Dicyclohexyl(3-isopropoxy-2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphine is a highly effective biarylphosphine ligand widely used in palladium-catalyzed cross-coupling reactions. The ligand provides excellent steric and electronic properties for challenging coupling reactions, particularly with sterically hindered or electron-rich substrates. It is commonly employed in combination with palladium sources to form highly active catalysts for Suzuki-Miyaura couplings, Buchwald-Hartwig aminations, and other C-C and C-N bond-forming reactions. The bulky triisopropyl substituents and the isopropoxy group create a unique steric environment that enhances catalyst stability and reactivity, while the dicyclohexylphosphino moiety imparts strong electron-donating character to the metal center. This ligand is bench-stable, soluble in most organic solvents, and is a valuable component in modern pharmaceutical synthesis and organic chemistry research.

Ephos; Dicyclohexyl(3-isopropoxy-2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphane; Dicyclohexyl(3-isopropoxy-2',4',6'-triisopropyl-2-biphenylyl)phosphine; Phosphine, dicyclohexyl[3-(1-methylethoxy)-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]-; Dicyclohexyl-[2-isopropoxy-6-(2,4,6-triisopropylphenyl)phenyl]phosphane; Dicyclohexyl[3-(1-methylethoxy)-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine; Bicyclohexyl(3-isopropoxy-2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphane

dicyclohexyl-[2-propan-2-yloxy-6-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane

CC(C)C1=CC(=C(C(=C1)C(C)C)C2=C(C(=CC=C2)OC(C)C)P(C3CCCCC3)C4CCCCC4)C(C)C

InChI=1S/C36H55OP/c1-24(2)28-22-32(25(3)4)35(33(23-28)26(5)6)31-20-15-21-34(37-27(7)8)36(31)38(29-16-11-9-12-17-29)30-18-13-10-14-19-30/h15,20-27,29-30H,9-14,16-19H2,1-8H3

FDAKNRLXSJBEFL-UHFFFAOYSA-N

612.7±55.0 °C at 760 mmHg

161-162 °C

98%

White powder

Store at 2-8 °C, under nitrogen