DIDS disodium salt
Product Information
Molecular Formula
C16H8N2Na2O6S4
Molecular Weight
498.48
Description
DIDS disodium salt is a stilbene sulfonate that acts as a ClC-Ka chloride channel blocker (IC50 = 100 μM). It blocks the maxi chloride channel in apical membranes from human placenta to inhibit the Cl- uptake. DIDS also has antagonistic activity at TRPM4 and TRPC4 channels.
Synonyms
4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt
IUPAC Name
disodium5-isothiocyanato-2-[(E)-2-(4-isothiocyanato-2-sulfonatophenyl)ethenyl]benzenesulfonate
SMILES
C1=CC(=C(C=C1N=C=S)S(=O)(=O)[O-])C=CC2=C(C=C(C=C2)N=C=S)S(=O)(=O)[O-].[Na+].[Na+]
InChI
InChI=1S/C16H10N2O6S4.2Na/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24;;/h1-8H,(H,19,20,21)(H,22,23,24);;/q;2*+1/p-2/b2-1+;;
InChI Key
GEPAYBXVXXBSKP-SEPHDYHBSA-L
Melting Point
>300°C (dec.)
Purity
≥95% by HPLC
Density
1.54
Appearance
Yellow to Dark Yellow Solid
Storage
0-10°C
Related CAS
53005-05-3 (free base)
Safety Information
Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Computed Properties
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
10
Rotatable Bond Count
4
Exact Mass
497.90605924 g/mol
Monoisotopic Mass
497.90605924 g/mol
Topological Polar Surface Area
220Ų
Heavy Atom Count
30
Formal Charge
0
Complexity
792
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
1
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
3
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2021338579-A1 | pH RESPONSIVE BLOCK COPOLYMER COMPOSITIONS AND MICELLES THAT INHIBIT MCT 1 AND RELATED PROTEINS | 2020-04-24 |
| WO-2021217111-A1 | Ph responsive block copolymer compositions and micelles that inhibit mct 1 and related proteins | 2020-04-24 |
| AU-2016246701-A1 | Oleaginous microalgae having an LPAAT ablation | 2015-04-06 |
| CN-102827916-B | Method for quantifying inorganic carbon approach for microalgae utilization | 2012-08-09 |
| KR-20110004413-A | Bivalent hydrazide compound conjugates for inhibiting cystic fibrosis transmembrane conduction regulator | 2008-04-04 |
| WO-2006020326-A2 | Methods of identifying compounds that modulate protein activity | 2004-08-13 |
| WO-2005079781-A1 | Therapeutic and/or prophylactic method | 2004-02-25 |
| US-2004019113-A1 | Phosphate transport inhibitors | 2001-12-26 |
| US-2007021509-A1 | Phosphate transport inhibitors | 2001-12-26 |
| US-7119120-B2 | Phosphate transport inhibitors | 2001-12-26 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 31886722 | 2020-02-01 | Several phosphate transport processes are present in vascular smooth muscle cells | American journal of physiology. Heart and circulatory physiology |
| 29229420 | 2018-03-01 | ROS-mediated oligomerization of VDAC2 is associated with quinocetone-induced apoptotic cell death | Toxicology in vitro : an international journal published in association with BIBRA |
| 25583444 | 2015-07-01 | Intermediate-conductance calcium-activated potassium channel KCa3.1 and chloride channel modulate chemokine ligand (CCL19/CCL21)-induced migration of dendritic cells | Translational research : the journal of laboratory and clinical medicine |
| 23589568 | 2013-05-06 | Attenuating homologous recombination stimulates an AID-induced antileukemic effect | The Journal of experimental medicine |
| 22998876 | 2012-09-20 | Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase | Neuron |
| 22578307 | 2012-08-01 | CFTR-mediated Cl(-) transport in the acinar and duct cells of rabbit lacrimal gland | Current eye research |
| 22684478 | 2012-08-01 | Modulation of the hepatocyte rough endoplasmic reticulum single chloride channel by nucleotide-Mg2+ interaction | Pflugers Archiv : European journal of physiology |
| 22496242 | 2012-07-01 | ClC-3 is a candidate of the channel proteins mediating acid-activated chloride currents in nasopharyngeal carcinoma cells | American journal of physiology. Cell physiology |
| 22517357 | 2012-07-01 | Sat1 is dispensable for active oxalate secretion in mouse duodenum | American journal of physiology. Cell physiology |
| 22460716 | 2012-06-01 | A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter | American journal of physiology. Cell physiology |
