DIDS disodium salt

Product Information

Molecular Formula:
C16H8N2Na2O6S4
Molecular Weight:
498.48
Description
DIDS disodium salt is a stilbene sulfonate that acts as a ClC-Ka chloride channel blocker (IC50 = 100 μM). It blocks the maxi chloride channel in apical membranes from human placenta to inhibit the Cl- uptake. DIDS also has antagonistic activity at TRPM4 and TRPC4 channels.
Synonyms
4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt
IUPAC Name
disodium5-isothiocyanato-2-[(E)-2-(4-isothiocyanato-2-sulfonatophenyl)ethenyl]benzenesulfonate
Canonical SMILES
C1=CC(=C(C=C1N=C=S)S(=O)(=O)[O-])C=CC2=C(C=C(C=C2)N=C=S)S(=O)(=O)[O-].[Na+].[Na+]
InChI
InChI=1S/C16H10N2O6S4.2Na/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24;;/h1-8H,(H,19,20,21)(H,22,23,24);;/q;2*+1/p-2/b2-1+;;
InChI Key
GEPAYBXVXXBSKP-SEPHDYHBSA-L
Melting Point
>300°C (dec.)
Purity
≥95% by HPLC
Density
1.54
Appearance
Yellow to Dark Yellow Solid
Storage
0-10℃

Safety Information

Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].

Computed Properties

Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
10
Rotatable Bond Count
4
Exact Mass
497.90605924 g/mol
Monoisotopic Mass
497.90605924 g/mol
Topological Polar Surface Area
220Ų
Heavy Atom Count
30
Formal Charge
0
Complexity
792
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
1
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
3
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
US-2021338579-A1 pH RESPONSIVE BLOCK COPOLYMER COMPOSITIONS AND MICELLES THAT INHIBIT MCT 1 AND RELATED PROTEINS 2020-04-24
WO-2021217111-A1 Ph responsive block copolymer compositions and micelles that inhibit mct 1 and related proteins 2020-04-24
AU-2016246701-A1 Oleaginous microalgae having an LPAAT ablation 2015-04-06
CN-102827916-B Method for quantifying inorganic carbon approach for microalgae utilization 2012-08-09
KR-20110004413-A Bivalent hydrazide compound conjugates for inhibiting cystic fibrosis transmembrane conduction regulator 2008-04-04
WO-2006020326-A2 Methods of identifying compounds that modulate protein activity 2004-08-13
WO-2005079781-A1 Therapeutic and/or prophylactic method 2004-02-25
US-2004019113-A1 Phosphate transport inhibitors 2001-12-26
US-2007021509-A1 Phosphate transport inhibitors 2001-12-26
US-7119120-B2 Phosphate transport inhibitors 2001-12-26

Literatures

PMID Publication Date Title Journal
31886722 2020-02-01 Several phosphate transport processes are present in vascular smooth muscle cells American journal of physiology. Heart and circulatory physiology
29229420 2018-03-01 ROS-mediated oligomerization of VDAC2 is associated with quinocetone-induced apoptotic cell death Toxicology in vitro : an international journal published in association with BIBRA
25583444 2015-07-01 Intermediate-conductance calcium-activated potassium channel KCa3.1 and chloride channel modulate chemokine ligand (CCL19/CCL21)-induced migration of dendritic cells Translational research : the journal of laboratory and clinical medicine
23589568 2013-05-06 Attenuating homologous recombination stimulates an AID-induced antileukemic effect The Journal of experimental medicine
22998876 2012-09-20 Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase Neuron
22578307 2012-08-01 CFTR-mediated Cl(-) transport in the acinar and duct cells of rabbit lacrimal gland Current eye research
22684478 2012-08-01 Modulation of the hepatocyte rough endoplasmic reticulum single chloride channel by nucleotide-Mg2+ interaction Pflugers Archiv : European journal of physiology
22496242 2012-07-01 ClC-3 is a candidate of the channel proteins mediating acid-activated chloride currents in nasopharyngeal carcinoma cells American journal of physiology. Cell physiology
22517357 2012-07-01 Sat1 is dispensable for active oxalate secretion in mouse duodenum American journal of physiology. Cell physiology
22460716 2012-06-01 A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter American journal of physiology. Cell physiology
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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