Metformin EP Impurity A

Product Information

Molecular Formula:
C2H4N4
Molecular Weight:
84.08
Description
Metformin EP Impurity A is an impurity of Metformin (HCl), an oral hypoglycemic agent that slows electron transport in the oxidation pathway in mitochondria. Metformin has been reported to reverse Lupus symptoms in mice in conjunction.
Synonyms
Metformin Related Compound A USP; N-Cyanoguanidine; 1-Cyanoguanidine; CGNA; Guanidine-1-carbonitrile; Dicyandiamide
IUPAC Name
2-cyanoguanidine
Canonical SMILES
C(#N)N=C(N)N
InChI
InChI=1S/C2H4N4/c3-1-6-2(4)5/h(H4,4,5,6)
InChI Key
QGBSISYHAICWAH-UHFFFAOYSA-N
Melting Point
208-210°C
Purity
99%
Density
1.400 at 25 °C/4 °C
Solubility
Soluble in DMSO (Slightly), Methanol (Slightly, Sonicated)
Appearance
White to Off-White Solid
Application
Used as a curing agent (epoxy resins), flotation depressant (copper ores), intumescent paint ingredient, electrostatic powder coating ingredient, plasticizer (starch adhesives), fertilizer additive, nitrocellulose stabilizer, antioxidant (fats and oils), fire-proofing compound, case-hardening additive, cleaning and soldering compound, thinner for oil-well drilling muds, detergent stabilizer, and starch modifier; Also used in dye-stuffs and explosives.
Stability
STABLE WHEN DRY
LogP
Log P= -1.15
Vapor Pressure
0.000171 [mmHg]
Dissociation Constants
Ka= 6X10-15
Odor
Odorless

Safety Information

Precautionary Statement
P260 P262

Computed Properties

XLogP3
-1.2
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
0
Exact Mass
84.043596145 g/mol
Monoisotopic Mass
84.043596145 g/mol
Topological Polar Surface Area
88.2Ų
Heavy Atom Count
6
Formal Charge
0
Complexity
100
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
US-2015017856-A1 Article including intumescent coating, process for forming and use of same 2014-08-06
WO-2015200842-A1 Composition comprising metformin and a microbiome modulator 2014-06-26
US-2016074515-A1 Viscosity-reducing excipient compounds for protein formulations 2014-06-20
US-2016096879-A1 Viscosity-Reducing Excipient Compounds for Protein Formulations 2014-06-20
WO-2015189830-A1 Dual inhibitor compounds for use in the treatment of neurodegenerative disorders and alzheimer's disease 2014-06-13
WO-2015181265-A1 Hydrophilic coating for heat exchangers 2014-05-30
US-2015344750-A1 Use of epoxy film adhesive with high ink compatibility and thermal oxidative stability for printhead interstitial bonding in in high density printheads 2014-05-28
WO-2015181840-A1 Coating antimicrobic film compositions 2014-05-27
WO-2015175896-A1 Inserts for extruded members 2014-05-15
WO-2015168534-A1 Therapeutic treatment of gastrointestinal microbial imbalances through competitive microbe displacement 2014-05-02

Literatures

PMID Publication Date Title Journal
23142614 2012-12-15 Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups Bioorganic & medicinal chemistry letters
22948178 2012-10-01 Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups European journal of medicinal chemistry
22959205 2012-10-01 Synthesis and biological evaluation of cyanoguanidine derivatives of loratadine Bioorganic & medicinal chemistry letters
22590116 2012-05-01 Poly[bis-(1-carbamoylguanidinium) [tri-μ-chlorido-dichloridobismuthate(III)]] Acta crystallographica. Section E, Structure reports online
22170304 2012-01-16 Alkoxy-1,3,5-triazapentadien(e/ato) copper(II) complexes: template formation and applications for the preparation of pyrimidines and as catalysts for oxidation of alcohols to carbonyl products Chemistry (Weinheim an der Bergstrasse, Germany)
22197251 2012-01-13 A liquid chromatography-tandem mass spectrometry method for the detection of economically motivated adulteration in protein-containing foods Journal of chromatography. A
22259550 2012-01-01 Tris(2-carbamoylguanidinium) hydrogen fluoro-phospho-nate fluoro-phospho-nate monohydrate Acta crystallographica. Section E, Structure reports online
22489495 2012-01-01 [Effects of nitrification inhibitors DCD and DMPP on cinnamon soil' s gross nitrogen mineralization and nitrification rates] Ying yong sheng tai xue bao = The journal of applied ecology
21987304 2011-12-01 Synthesis and histamine H(3) and H(4) receptor activity of conformationally restricted cyanoguanidines related to UR-PI376 Archiv der Pharmazie
22220229 2011-12-01 Aging impairs vasodilatory responses in rats Korean journal of anesthesiology
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Related Products

Online Inquiry
  • Verification code
USA
  • International:
  • US & Canada (Toll free):
  • Email:
  • Fax:
UK
  • Email:
Copyright © 2024 BOC Sciences. All rights reserved.
Inquiry Basket