Metformin EP Impurity A
Product Information
Molecular Formula
C2H4N4
Molecular Weight
84.08
Description
Metformin EP Impurity A is an impurity of Metformin (HCl), an oral hypoglycemic agent that slows electron transport in the oxidation pathway in mitochondria. Metformin has been reported to reverse Lupus symptoms in mice in conjunction.
Synonyms
Metformin Related Compound A USP; N-Cyanoguanidine; 1-Cyanoguanidine; CGNA; Guanidine-1-carbonitrile; Dicyandiamide
IUPAC Name
2-cyanoguanidine
SMILES
C(#N)N=C(N)N
InChI
InChI=1S/C2H4N4/c3-1-6-2(4)5/h(H4,4,5,6)
InChI Key
QGBSISYHAICWAH-UHFFFAOYSA-N
Melting Point
208-211 °C
Purity
99%
Density
1.400 g/cm3 at 25 °C
Solubility
Soluble in DMSO (Slightly), Methanol (Slightly, Sonicated)
Appearance
White to Off-White Solid
Application
Used as a curing agent (epoxy resins), flotation depressant (copper ores), intumescent paint ingredient, electrostatic powder coating ingredient, plasticizer (starch adhesives), fertilizer additive, nitrocellulose stabilizer, antioxidant (fats and oils), fire-proofing compound, case-hardening additive, cleaning and soldering compound, thinner for oil-well drilling muds, detergent stabilizer, and starch modifier; Also used in dye-stuffs and explosives.
Storage
Store at 2-8 °C
Stability
STABLE WHEN DRY
LogP
Log P= -1.15
Vapor Pressure
0.000171 [mmHg]
Dissociation Constants
Ka= 6X10-15
Odor
Odorless
Related CAS
5678-96-6 (sodium salt) 25752-57-2 (zinc salt)
Safety Information
Precautionary Statement
P260 P262
QC Data
Computed Properties
XLogP3
-1.2
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
0
Exact Mass
84.043596145 g/mol
Monoisotopic Mass
84.043596145 g/mol
Topological Polar Surface Area
88.2Ų
Heavy Atom Count
6
Formal Charge
0
Complexity
100
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2015017856-A1 | Article including intumescent coating, process for forming and use of same | 2014-08-06 |
| WO-2015200842-A1 | Composition comprising metformin and a microbiome modulator | 2014-06-26 |
| US-2016074515-A1 | Viscosity-reducing excipient compounds for protein formulations | 2014-06-20 |
| US-2016096879-A1 | Viscosity-Reducing Excipient Compounds for Protein Formulations | 2014-06-20 |
| WO-2015189830-A1 | Dual inhibitor compounds for use in the treatment of neurodegenerative disorders and alzheimer's disease | 2014-06-13 |
| WO-2015181265-A1 | Hydrophilic coating for heat exchangers | 2014-05-30 |
| US-2015344750-A1 | Use of epoxy film adhesive with high ink compatibility and thermal oxidative stability for printhead interstitial bonding in in high density printheads | 2014-05-28 |
| WO-2015181840-A1 | Coating antimicrobic film compositions | 2014-05-27 |
| WO-2015175896-A1 | Inserts for extruded members | 2014-05-15 |
| WO-2015168534-A1 | Therapeutic treatment of gastrointestinal microbial imbalances through competitive microbe displacement | 2014-05-02 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 23142614 | 2012-12-15 | Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups | Bioorganic & medicinal chemistry letters |
| 22948178 | 2012-10-01 | Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups | European journal of medicinal chemistry |
| 22959205 | 2012-10-01 | Synthesis and biological evaluation of cyanoguanidine derivatives of loratadine | Bioorganic & medicinal chemistry letters |
| 22590116 | 2012-05-01 | Poly[bis-(1-carbamoylguanidinium) [tri-μ-chlorido-dichloridobismuthate(III)]] | Acta crystallographica. Section E, Structure reports online |
| 22170304 | 2012-01-16 | Alkoxy-1,3,5-triazapentadien(e/ato) copper(II) complexes: template formation and applications for the preparation of pyrimidines and as catalysts for oxidation of alcohols to carbonyl products | Chemistry (Weinheim an der Bergstrasse, Germany) |
| 22197251 | 2012-01-13 | A liquid chromatography-tandem mass spectrometry method for the detection of economically motivated adulteration in protein-containing foods | Journal of chromatography. A |
| 22259550 | 2012-01-01 | Tris(2-carbamoylguanidinium) hydrogen fluoro-phospho-nate fluoro-phospho-nate monohydrate | Acta crystallographica. Section E, Structure reports online |
| 22489495 | 2012-01-01 | [Effects of nitrification inhibitors DCD and DMPP on cinnamon soil' s gross nitrogen mineralization and nitrification rates] | Ying yong sheng tai xue bao = The journal of applied ecology |
| 21987304 | 2011-12-01 | Synthesis and histamine H(3) and H(4) receptor activity of conformationally restricted cyanoguanidines related to UR-PI376 | Archiv der Pharmazie |
| 22220229 | 2011-12-01 | Aging impairs vasodilatory responses in rats | Korean journal of anesthesiology |
