Povidone-iodine

Product Information

Molecular Formula:
(C6H9NO)n.xI
Description
Povidone-iodine can be used as a topical preservative. It has activity against Gram-positive and Gram-negative bacteria, fungi, parasites, viruses and yeast.
Synonyms
Betadine; Isodine; PVP Iodine
IUPAC Name
1-ethenylpyrrolidin-2-one;molecular iodine
Canonical SMILES
C=CN1CCCC1=O.II
InChI
InChI=1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)8;1-2/h2H,1,3-5H2;
InChI Key
CPKVUHPKYQGHMW-UHFFFAOYSA-N
Boiling Point
217.6°C at 760 mmHg
Melting Point
300°C
Flash Point
93.9ºC
Solubility
Soluble in DMSO, Water
Appearance
Red-brown Crystalline Powder
Application
Use to clean contaminated wounds and for pre-operative preparation of the skin; Used as a suspending agent, dispersing agent, and vehicle for pharmaceuticals, as a blood volume expander, topical antiseptic, and for infections of the skin and mucous membranes; The iodine can be radiolabeled for research applications.
Storage
Store at -20°C
Stability
Stable under normal temperatures and pressures.
LogP
2.46160
Vapor Pressure
0.132mmHg at 25°C
Odor
A slight characteristic odor

Safety Information

Precautionary Statement
P262

Computed Properties

Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
1
Rotatable Bond Count
1
Exact Mass
364.87736 g/mol
Monoisotopic Mass
364.87736 g/mol
Topological Polar Surface Area
20.3Ų
Heavy Atom Count
10
Formal Charge
0
Complexity
120
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
2
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-114181223-A Cephalotaxine derivative and preparation method and application thereof 2022-01-05
CN-114177345-A Tissue glue composition for pet incision closure and preparation method thereof 2021-12-20
CN-113940298-A 48-hour high-efficiency germination and launching method for leech egg cocoons 2021-12-08
CN-114106401-A Porous chitosan membrane and preparation method and application thereof 2021-12-03
CN-114146226-A Bone marrow mesenchymal stem cell/degradable hydrogel composite material and preparation method and application thereof 2021-11-30
CN-114028377-A Novel medical application of cafestol 2021-11-29
CN-114158506-A Artificial breeding method for pond greenhouse crayfishes 2021-11-26
CN-114107297-A MiRNA (micro ribonucleic acid) mimic and application thereof 2021-11-25
CN-114027321-A Iodine disinfectant and preparation method thereof 2021-11-23
CN-114158554-A Iodine disinfection tablet and preparation method thereof 2021-11-23

Literatures

PMID Publication Date Title Journal
23341010 2013-02-19 Broad-spectrum virucidal activity of (NVC-422) N,N-dichloro-2,2-dimethyltaurine against viral ocular pathogens in vitro Investigative ophthalmology & visual science
22590998 2012-11-01 Does vaginal preparation with povidone-iodine prior to caesarean delivery reduce the risk of endometritis? A randomized controlled trial The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
23079318 2012-11-01 Bilateral Fusarium oxysporum keratitis after laser in situ keratomileusis Journal of cataract and refractive surgery
23090520 2012-11-01 Chlorhexidine-alcohol compared with povidone-iodine for surgical-site antisepsis in cesarean deliveries Obstetrics and gynecology
22740305 2012-09-01 Effectiveness of 1.25 % povidone-iodine combined with topical levofloxacin against conjunctival flora in intravitreal injection Japanese journal of ophthalmology
22878383 2012-09-01 Evaluation of 0.3% gatifloxacin hydrochloride in decontamination of donor corneas Eye & contact lens
23094343 2012-09-01 Does the direct application of povidone-lodine hasten hemostasis of the cannulation site after the removal of hemodialysis needles? Nephrology nursing journal : journal of the American Nephrology Nurses' Association
22771256 2012-08-17 Simultaneous determination of iodide and iodate in povidone iodine solution by ion chromatography with homemade and exchange capacity controllable columns and column-switching technique Journal of chromatography. A
22683906 2012-08-01 Evaluation of the wound healing activity of methanol extract of Pedilanthus tithymaloides (L.) Poit leaf and its isolated active constituents in topical formulation Journal of ethnopharmacology
22760386 2012-07-03 Comparison of two preoperative skin antiseptic preparations and resultant surgical incise drape adhesion to skin in healthy volunteers The Journal of bone and joint surgery. American volume
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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