Spermine tetrahydrochloride
Product Information
Molecular Formula
C10H26N4.4HCl
Molecular Weight
348.19
Description
Spermine tetrahydrochloride is a polyamine that binds to and modulates NMDA receptor channel. Spermine also acts as a GluR inhibitor, PLCα inhibitor and PLCδ activator.
Synonyms
N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride; Neuridine tetrahydrochloride; Musculamine tetrahydrochloride
IUPAC Name
N,N'-bis(3-aminopropyl)butane-1,4-diaminetetrahydrochloride
SMILES
C(CCNCCCN)CNCCCN.Cl.Cl.Cl.Cl
InChI
InChI=1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
InChI Key
XLDKUDAXZWHPFH-UHFFFAOYSA-N
Melting Point
310-311 °C (dec.)(lit.)
Purity
>98.0%(T)(N)
Density
1.01 g/mL at 20 °C
Appearance
White to Almost white powder to crystal
Application
Found widely in nature and essential for tissue growth; Used as a tool in biochemical research; Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells. Formed from spermidine, it is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. . . . Spermine is associated with nucleic acids and is thought to stabilize helical structure, in particular, in viruses.
Related CAS
71-44-3 (free base)
Safety Information
Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Computed Properties
Hydrogen Bond Donor Count
8
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
11
Exact Mass
348.119508 g/mol
Monoisotopic Mass
346.122458 g/mol
Topological Polar Surface Area
76.1Ų
Heavy Atom Count
18
Formal Charge
0
Complexity
86.1
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
5
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114146087-A | Application of hirsutine in medicine for treating thrombocytopenia | 2021-12-08 |
| KR-20210048446-A | Method for preparing fermented rice bran by using weissella koreensis and fermented rice bran prepared thereby | 2021-01-19 |
| US-2021401013-A1 | Sweet protein from truffle | 2020-06-25 |
| WO-2021263158-A1 | Sweet protein from truffle | 2020-06-25 |
| WO-2021222333-A1 | Kras specific antibodies and uses thereof | 2020-04-30 |
| CN-111500571-A | Eukaryotic DNA extraction method suitable for Hi-C technology, rinsing liquid and application | 2020-04-08 |
| WO-2021152584-A1 | Methods of analyzing cell membranes | 2020-01-28 |
| KR-20210048110-A | Method for preparing fermented rice bran by using weissella koreensis and fermented rice bran prepared thereby | 2019-10-23 |
| WO-2021053623-A1 | Automated solution dispenser | 2019-09-18 |
| WO-2020209803-A1 | A ribozyme comprising a target-binding domain | 2019-04-12 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 20925391 | 2010-11-11 | Targeting the polyamine transport system with benzazepine- and azepine-polyamine conjugates | Journal of medicinal chemistry |
