Y15
| Catalog Number | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| BPM-092576 | 5 g | $299 | In stock |
Product Information
Molecular Formula
C6H14Cl4N4
Molecular Weight
284.01
Description
Y15 is a novel small molecule FAK phosphorylation inhibitor. It is a direct inhibitor of FAK1 autophosphorylation, blocking phosphorylation of Y397. Besides, it promotes cell detachment and inhibits cell adhesion of cells in culture. It has been used to demonstrate a role for FAK in the regulation of aortic stiffness.
Synonyms
1,2,4,5-benzenetetramine tetrahydrochloride; Y15 hydrochloride; Y15 tetrahydrochloride; Y 15; Y-15 FAK Inhibitor 14
IUPAC Name
benzene-1,2,4,5-tetramine;tetrahydrochloride
SMILES
NC1=CC(N)=C(N)C=C1N.[H]Cl.[H]Cl.[H]Cl.[H]Cl
InChI
1S/C6H10N4.4ClH/c7-3-1-4(8)6(10)2-5(3)9;;;;/h1-2H,7-10H2;4*1H
InChI Key
BZDGCIJWPWHAOF-UHFFFAOYSA-N
Melting Point
≥300 °C (lit.)
Flash Point
Not applicable
Purity
≥95%
Appearance
Light green to green solid powder
Computed Properties
Hydrogen Bond Donor Count
8
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
0
Exact Mass
283.994307 g/mol
Monoisotopic Mass
281.997257 g/mol
Topological Polar Surface Area
104Ų
Heavy Atom Count
14
Formal Charge
0
Complexity
90.3
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
5
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-113933501-A | Immunomagnetic bead and preparation method and application thereof | 2021-11-09 |
| CN-113735904-A | Preparation method of lubricating additive | 2021-09-17 |
| CN-113809325-A | Alkaline water-based secondary battery based on electroactive covalent organic framework polymer and application | 2021-08-30 |
| CN-113594520-A | Preparation method of polybenzimidazole containing troger base and phosphoric acid doped high-temperature proton exchange membrane thereof | 2021-06-15 |
| CN-113101815-A | Novel composite membrane based on BILP-101x and preparation method and application thereof | 2021-04-08 |
| CN-112876586-A | Method for coagulating ABS graft latex | 2021-01-18 |
| CN-112808006-A | High-rejection-rate covalent organic framework membrane, and raw material composition and preparation method thereof | 2021-01-08 |
| CN-112591857-A | electro-Fenton gas diffusion electrode and preparation method thereof | 2020-12-07 |
| CN-112608434-A | Phenol polymer containing benzo-heterocyclic structure unit and preparation method and application thereof | 2020-11-27 |
| CN-112452347-A | Preparation method and application of 2D-RNPG @ CoxOy composite material | 2020-10-20 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 21993963 | 2012-02-01 | Thrombin-dependent modulation of β1-integrin-mediated signaling up-regulates prolidase and HIF-1α through p-FAK in colorectal cancer cells | Molecular and cellular biochemistry |
| 22276220 | 2012-01-01 | Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation | PloS one |
| 20410685 | 2010-03-15 | Targeting the MYCN effector, FAK, in neuroblastoma | Cell cycle (Georgetown, Tex.) |
| 20160475 | 2010-03-01 | Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma | Cell cycle (Georgetown, Tex.) |
| 19571674 | 2009-08-01 | A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer | Cell cycle (Georgetown, Tex.) |
| 18989950 | 2008-12-11 | A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth | Journal of medicinal chemistry |
