2,2'-(Ethylenedioxy)bis(ethylamine)
Product Information
Molecular Formula
C6H16N2O2
Molecular Weight
148.20
Description
Bis-NH2-PEG2 is a PROTAC linker, which refers to the alkyl/ether composition. Bis-NH2-PEG2 can be used in the synthesis of a series of PROTACs. Bis-NH2-PEG2 is a PEG derivative containing two amino groups. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
Synonyms
2-[2-(2-aminoethoxy)ethoxy]ethanamine; 2-[2-(2-aminoethoxy)ethoxy]ethanamine
IUPAC Name
2-[2-(2-aminoethoxy)ethoxy]ethanamine
SMILES
C(COCCOCCN)N
InChI
InChI=1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2
InChI Key
IWBOPFCKHIJFMS-UHFFFAOYSA-N
Boiling Point
123 °C / 12 mmHg
Flash Point
121 °C
Purity
> 98.0 % (GC) (T)
Density
1.015 g/mL at 25 °C (lit.)
Solubility
DMSO : 250 mg/mL (ultrasonic)
Appearance
Light yellow clear liquid
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Refractive Index
n20/D 1.461 (lit.)
LogP
0.33760
Safety Information
Hazards
H302:
Harmful if swallowed.
H314:
Causes severe skin burns and eye damage.
H317:
May cause an allergic skin reaction.
H334:
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Harmful if swallowed.
H314:
Causes severe skin burns and eye damage.
H317:
May cause an allergic skin reaction.
H334:
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statement
P260, P261, P264, P270, P271, P272, P280, P285, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P304+P341, P305+P351+P338, P310, P312, P321, P330, P333+P313, P342+P311, P363, P403+P233, P405, and P501
Signal Word
Danger
Computed Properties
XLogP3
-2
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
7
Exact Mass
148.121177757 g/mol
Monoisotopic Mass
148.121177757 g/mol
Topological Polar Surface Area
70.5Ų
Heavy Atom Count
10
Formal Charge
0
Complexity
53.7
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114163374-A | Dendritic macromolecule and preparation method and application thereof | 2021-12-17 |
| CN-113929906-A | Self-crosslinkable isocyanurate polymer and anti-reflective coating composition, preparation method thereof and pattern forming method | 2021-10-14 |
| CN-113930151-A | Anti-reflective coating composition containing self-crosslinkable mercaptomelamine polymer, preparation method thereof and pattern forming method | 2021-10-14 |
| CN-113754862-A | Non-ionic self-emulsifying water-based epoxy curing agent and preparation method and application thereof | 2021-09-02 |
| CN-113354546-A | Method for preparing 1, 8-diamino-3, 6-dioxyoctane by hydrogenating triethylene glycol | 2021-06-08 |
| CN-113292721-A | Polythiourea compound and preparation method and application thereof | 2021-05-19 |
| CN-112960844-A | Reactor for separating and recovering precious metals and application thereof | 2021-03-31 |
| CN-113145082-A | Modified polymer adsorbent for selectively adsorbing and recovering noble metal ions and preparation method thereof | 2021-03-31 |
| CN-113149123-A | Treatment method for selectively adsorbing and recovering precious metal ions in wastewater by using modified polymer adsorbent | 2021-03-31 |
| CN-112979924-A | Low-molecular-weight polyamide curing agent, and preparation method and application thereof | 2021-03-12 |
Literatures
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| 22234403 | 2012-05-01 | Improving selectivity in gas chromatography by using chemically modified multi-walled carbon nanotubes as stationary phase | Analytical and bioanalytical chemistry |
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| 20933232 | 2010-11-12 | Multi-walled carbon nanotubes as the gas chromatographic stationary phase: role of their functionalization in the analysis of aliphatic alcohols and esters | Journal of chromatography. A |
| 20111985 | 2010-05-01 | In vitro evaluation of folic acid modified carboxymethyl chitosan nanoparticles loaded with doxorubicin for targeted delivery | Journal of materials science. Materials in medicine |
| 19261416 | 2010-02-01 | Gd-EDDA/HYNIC-RGD as an MR molecular probe imaging integrin alphanubeta3 receptor-expressed tumor-MR molecular imaging of angiogenesis | European journal of radiology |
| 21582224 | 2009-02-21 | 3,3'-Dibenzoyl-1,1'-(3,6-dioxaoctane-1,8-di-yl)dithio-urea | Acta crystallographica. Section E, Structure reports online |
