2,2'-(Ethylenedioxy)bis(ethylamine)

Product Information

Molecular Formula:
C6H16N2O2
Molecular Weight:
148.20
Description
Bis-NH2-PEG2 is a PROTAC linker, which refers to the alkyl/ether composition. Bis-NH2-PEG2 can be used in the synthesis of a series of PROTACs. Bis-NH2-PEG2 is a PEG derivative containing two amino groups. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
Synonyms
2-[2-(2-aminoethoxy)ethoxy]ethanamine; 2-[2-(2-aminoethoxy)ethoxy]ethanamine
IUPAC Name
2-[2-(2-aminoethoxy)ethoxy]ethanamine
Canonical SMILES
C(COCCOCCN)N
InChI
InChI=1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2
InChI Key
IWBOPFCKHIJFMS-UHFFFAOYSA-N
Boiling Point
123 °C / 12 mmHg
Flash Point
121 °C
Purity
> 98.0 % (GC) (T)
Density
1.015 g/mL at 25 °C (lit.)
Solubility
DMSO : 250 mg/mL (ultrasonic)
Appearance
Light yellow clear liquid
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Refractive Index
n20/D 1.461 (lit.)
LogP
0.33760

Safety Information

Hazards
H302:
Harmful if swallowed.
H314:
Causes severe skin burns and eye damage.
H317:
May cause an allergic skin reaction.
H334:
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statement
P260, P261, P264, P270, P271, P272, P280, P285, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P304+P341, P305+P351+P338, P310, P312, P321, P330, P333+P313, P342+P311, P363, P403+P233, P405, and P501
Signal Word
Danger

Computed Properties

XLogP3
-2
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
7
Exact Mass
148.121177757 g/mol
Monoisotopic Mass
148.121177757 g/mol
Topological Polar Surface Area
70.5Ų
Heavy Atom Count
10
Formal Charge
0
Complexity
53.7
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

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Literatures

PMID Publication Date Title Journal
23020277 2012-10-24 Alginic acid nanoparticles prepared through counterion complexation method as a drug delivery system ACS applied materials & interfaces
22841851 2012-10-15 In vitro antimicrobial activity of nanoconjugated vancomycin against drug resistant Staphylococcus aureus International journal of pharmaceutics
22884990 2012-09-15 Facile synthesis of a dimeric dipyrrole-polyamide and synergetic DNA-cleaving activity of its Cu(II) complex Bioorganic & medicinal chemistry letters
22700230 2012-06-01 Synergetic DNA-cleaving activities of the metal complexes of a polyether-tethered pyrrole-polyamide dimer Chemistry & biodiversity
22234403 2012-05-01 Improving selectivity in gas chromatography by using chemically modified multi-walled carbon nanotubes as stationary phase Analytical and bioanalytical chemistry
21754397 2011-05-01 1,1'-[(1E,11E)-5,8-Dioxa-2,11-diazo-nia-dodeca-1,11-diene-1,12-di-yl]dinaph-thal-en-2-olate Acta crystallographica. Section E, Structure reports online
20933232 2010-11-12 Multi-walled carbon nanotubes as the gas chromatographic stationary phase: role of their functionalization in the analysis of aliphatic alcohols and esters Journal of chromatography. A
20111985 2010-05-01 In vitro evaluation of folic acid modified carboxymethyl chitosan nanoparticles loaded with doxorubicin for targeted delivery Journal of materials science. Materials in medicine
19261416 2010-02-01 Gd-EDDA/HYNIC-RGD as an MR molecular probe imaging integrin alphanubeta3 receptor-expressed tumor-MR molecular imaging of angiogenesis European journal of radiology
21582224 2009-02-21 3,3'-Dibenzoyl-1,1'-(3,6-dioxaoctane-1,8-di-yl)dithio-urea Acta crystallographica. Section E, Structure reports online
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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